Pathophysiologic Mechanisms in Heart Failure. Role of the Sympathetic Nervous System
Abstract The syndrome of heart failure involves complex pathophysiologic mechanisms and is associated with an extremely high morbidity, mortality, and economic costs. This growing global epidemic has diverse etiologies and is fundamentally characterized by dyshomeostasis between heart and kidneys, l...
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| Published in: | The American journal of the medical sciences Vol. 353; no. 1; pp. 27 - 30 |
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| Abstract | Abstract The syndrome of heart failure involves complex pathophysiologic mechanisms and is associated with an extremely high morbidity, mortality, and economic costs. This growing global epidemic has diverse etiologies and is fundamentally characterized by dyshomeostasis between heart and kidneys, leading to development and progression of the cardio-renal syndrome. Excessive and sustained sympatho-excitation has emerged as one prominent factor involved in the structural and functional dysfunction of multiple organ systems during this disease. Studies in experimental models of heart failure indicate that ablation of the renal nerves may help restore renal sodium and water equilibrium as well as the attenuation of adverse cardiac remodeling. With the recent development of minimally invasive endovascular renal denervation in humans, it is anticipated that this technology would become a novel and important paradigm shift in the management of heart failure. |
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| AbstractList | Abstract The syndrome of heart failure involves complex pathophysiologic mechanisms and is associated with an extremely high morbidity, mortality, and economic costs. This growing global epidemic has diverse etiologies and is fundamentally characterized by dyshomeostasis between heart and kidneys, leading to development and progression of the cardio-renal syndrome. Excessive and sustained sympatho-excitation has emerged as one prominent factor involved in the structural and functional dysfunction of multiple organ systems during this disease. Studies in experimental models of heart failure indicate that ablation of the renal nerves may help restore renal sodium and water equilibrium as well as the attenuation of adverse cardiac remodeling. With the recent development of minimally invasive endovascular renal denervation in humans, it is anticipated that this technology would become a novel and important paradigm shift in the management of heart failure. The syndrome of heart failure involves complex pathophysiologic mechanisms and is associated with extremely high-morbidity, mortality and economic costs. This growing global epidemic has diverse etiologies and is fundamentally characterized by dyshomeostasis between heart and kidneys, leading to development and progression of the cardiorenal syndrome. Excessive and sustained sympathoexcitation has emerged as a single prominent factor involved in the structural and functional dysfunction of multiple organ systems during this disease. Studies in experimental models of heart failure indicate that ablation of the renal nerves may help restore renal sodium and water equilibrium as well as the attenuation of adverse cardiac remodeling. With the recent development of minimally invasive endovascular renal denervation in humans, it is anticipated that this technology would become a novel and important paradigm shift in the management of heart failure. |
| Author | Villarreal, Daniel, MD Antoine, Steve, MD Imam, Haider, MD Vaidya, Gaurang, MD |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28104100$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1056/NEJMoa1402670 10.1016/j.jacc.2008.05.068 10.1161/HYPERTENSIONAHA.109.138610 10.1161/CIR.0b013e31829e8807 10.1016/j.ijcard.2012.09.019 10.1152/physrev.1997.77.1.75 10.1016/j.jacc.2008.08.080 10.1590/S0100-879X2004000200017 10.1097/MAJ.0b013e318242a631 10.1007/s380-002-8317-8 10.3389/fphys.2015.00224 10.1016/j.hrthm.2013.07.015 10.1016/j.jacc.2011.11.034 10.1016/S0140-6736(09)60566-3 10.1161/CIRCRESAHA.114.302589 |
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| References | Krum, Schlaich, Whitbourn (bib15) 2009; 373 Damman, van Deursen, Navis, Voors, van Veldhuisen, Hillege (bib9) 2009; 53 Mullens, Abrahams, Francis (bib10) 2009; 53 Florea, Cohn (bib2) 2014; 114 Nozawa, Igawa, Fujii (bib13) 2002; 16 Bhatt, Kandzari, O’Neill (bib16) 2014; 370 Dibona, Kopp (bib3) 1997; 77 Linz, Wirth, Ukena (bib12) 2013; 10 Fischell, Fischell, Ghazarossian (bib18) 2015; 9 Schiller, Pellegrino, Zucker (bib11) 2015; 6 Villarreal, Freeman, Johnson (bib5) 1993; 264 Schlaich, Sobotka, Krum (bib7) 2009; 54 Villarreal, Freeman, Johnson, Simmons (bib4) 1994; 26 Yancy, Jessup, Bozkurt (bib1) 2013; 128 Souza, Mill, Cabral (bib6) 2004; 73 Kshatriya, Kozman, Siddiqui (bib8) 2012; 344 Brandt, Mahfoud, Reda (bib14) 2012; 59 Davies, Manisty, Petraco (bib17) 2013; 162 Yancy (10.1016/j.amjms.2016.06.016_bib1) 2013; 128 Kshatriya (10.1016/j.amjms.2016.06.016_bib8) 2012; 344 Villarreal (10.1016/j.amjms.2016.06.016_bib4) 1994; 26 Florea (10.1016/j.amjms.2016.06.016_bib2) 2014; 114 Brandt (10.1016/j.amjms.2016.06.016_bib14) 2012; 59 Fischell (10.1016/j.amjms.2016.06.016_bib18) 2015; 9 Villarreal (10.1016/j.amjms.2016.06.016_bib5) 1993; 264 Schiller (10.1016/j.amjms.2016.06.016_bib11) 2015; 6 Krum (10.1016/j.amjms.2016.06.016_bib15) 2009; 373 Nozawa (10.1016/j.amjms.2016.06.016_bib13) 2002; 16 Mullens (10.1016/j.amjms.2016.06.016_bib10) 2009; 53 Dibona (10.1016/j.amjms.2016.06.016_bib3) 1997; 77 Souza (10.1016/j.amjms.2016.06.016_bib6) 2004; 73 Davies (10.1016/j.amjms.2016.06.016_bib17) 2013; 162 Schlaich (10.1016/j.amjms.2016.06.016_bib7) 2009; 54 Bhatt (10.1016/j.amjms.2016.06.016_bib16) 2014; 370 Linz (10.1016/j.amjms.2016.06.016_bib12) 2013; 10 Damman (10.1016/j.amjms.2016.06.016_bib9) 2009; 53 |
| References_xml | – volume: 370 start-page: 1393 year: 2014 end-page: 1401 ident: bib16 article-title: SYMPLICITY HTN-3 Investigators. A controlled trial of renal denervation for resistant hypertension publication-title: N Engl J Med contributor: fullname: O’Neill – volume: 26 start-page: R1599 year: 1994 end-page: R1604 ident: bib4 article-title: Effects of renal denervation on postprandial sodium excretion in experimental heart failure publication-title: Am J Physiol contributor: fullname: Simmons – volume: 59 start-page: 901 year: 2012 end-page: 909 ident: bib14 article-title: Renal sympathetic denervation reduces left ventricular hypertrophy and improves cardiac function in patients with resistant hypertension publication-title: J Am Coll Cardiol contributor: fullname: Reda – volume: 162 start-page: 189 year: 2013 end-page: 192 ident: bib17 article-title: First-in-man safety evaluation of renal denervation for chronic systolic heart failure: primary outcome from REACH-Pilot study publication-title: Int J Cardiol contributor: fullname: Petraco – volume: 114 start-page: 1815 year: 2014 end-page: 1826 ident: bib2 article-title: The autonomic nervous system and heart failure publication-title: Circ Res contributor: fullname: Cohn – volume: 77 start-page: 75 year: 1997 end-page: 197 ident: bib3 article-title: Neural control of renal function publication-title: Physiol Rev contributor: fullname: Kopp – volume: 53 start-page: 582 year: 2009 end-page: 588 ident: bib9 article-title: Increased central venous pressure is associated with impaired renal function and mortality in a broad spectrum of patients with cardiovascular disease publication-title: J Am Coll Cardiol contributor: fullname: Hillege – volume: 16 start-page: 51 year: 2002 end-page: 56 ident: bib13 article-title: Effects of long-term renal sympathetic denervation on heart failure after myocardial infarction in rats publication-title: Heart Vessels contributor: fullname: Fujii – volume: 9 start-page: 209051 year: 2015 end-page: 209052 ident: bib18 article-title: Peregrime system infusion catheter for perivascular renal denervation publication-title: J Med Dev contributor: fullname: Ghazarossian – volume: 6 start-page: 224 year: 2015 ident: bib11 article-title: The renal nerves in chronic heart failure: efferent and afferent mechanisms publication-title: Front Physiol contributor: fullname: Zucker – volume: 373 start-page: 1275 year: 2009 end-page: 1281 ident: bib15 article-title: Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study publication-title: Lancet contributor: fullname: Whitbourn – volume: 53 start-page: 589 year: 2009 end-page: 596 ident: bib10 article-title: Importance of venous congestion for worsening of renal function in advanced decompensated heart failure publication-title: J Am Coll Cardiol contributor: fullname: Francis – volume: 73 start-page: 285 year: 2004 end-page: 293 ident: bib6 article-title: Chronic experimental myocardial infarction produces antinatriuresis by a renal nerve dependent mechanism publication-title: Braz J Biol Res contributor: fullname: Cabral – volume: 54 start-page: 1195 year: 2009 end-page: 1201 ident: bib7 article-title: Renal denervation as a therapeutic approach for hypertension: novel implications for an old concept publication-title: Hypertension contributor: fullname: Krum – volume: 264 start-page: H1187 year: 1993 end-page: H1193 ident: bib5 article-title: Neurohumoral modulators and sodium balance in experimental heart failure publication-title: Am J Physiol contributor: fullname: Johnson – volume: 344 start-page: 228 year: 2012 end-page: 232 ident: bib8 article-title: The kidney in heart failure: friend or foe? publication-title: Am J Med Sci contributor: fullname: Siddiqui – volume: 10 start-page: 1525 year: 2013 end-page: 1530 ident: bib12 article-title: Renal denervation suppresses ventricular arrhythmias during acute ventricular ischemia in pigs publication-title: Heart Rhythm contributor: fullname: Ukena – volume: 128 start-page: e240 year: 2013 end-page: e327 ident: bib1 article-title: 2013 ACCF/AHA guidelines for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines publication-title: Circulation contributor: fullname: Bozkurt – volume: 370 start-page: 1393 year: 2014 ident: 10.1016/j.amjms.2016.06.016_bib16 article-title: SYMPLICITY HTN-3 Investigators. A controlled trial of renal denervation for resistant hypertension publication-title: N Engl J Med doi: 10.1056/NEJMoa1402670 contributor: fullname: Bhatt – volume: 53 start-page: 589 issue: 7 year: 2009 ident: 10.1016/j.amjms.2016.06.016_bib10 article-title: Importance of venous congestion for worsening of renal function in advanced decompensated heart failure publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2008.05.068 contributor: fullname: Mullens – volume: 54 start-page: 1195 issue: 6 year: 2009 ident: 10.1016/j.amjms.2016.06.016_bib7 article-title: Renal denervation as a therapeutic approach for hypertension: novel implications for an old concept publication-title: Hypertension doi: 10.1161/HYPERTENSIONAHA.109.138610 contributor: fullname: Schlaich – volume: 128 start-page: e240 year: 2013 ident: 10.1016/j.amjms.2016.06.016_bib1 article-title: 2013 ACCF/AHA guidelines for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines publication-title: Circulation doi: 10.1161/CIR.0b013e31829e8807 contributor: fullname: Yancy – volume: 162 start-page: 189 year: 2013 ident: 10.1016/j.amjms.2016.06.016_bib17 article-title: First-in-man safety evaluation of renal denervation for chronic systolic heart failure: primary outcome from REACH-Pilot study publication-title: Int J Cardiol doi: 10.1016/j.ijcard.2012.09.019 contributor: fullname: Davies – volume: 77 start-page: 75 year: 1997 ident: 10.1016/j.amjms.2016.06.016_bib3 article-title: Neural control of renal function publication-title: Physiol Rev doi: 10.1152/physrev.1997.77.1.75 contributor: fullname: Dibona – volume: 53 start-page: 582 year: 2009 ident: 10.1016/j.amjms.2016.06.016_bib9 article-title: Increased central venous pressure is associated with impaired renal function and mortality in a broad spectrum of patients with cardiovascular disease publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2008.08.080 contributor: fullname: Damman – volume: 73 start-page: 285 year: 2004 ident: 10.1016/j.amjms.2016.06.016_bib6 article-title: Chronic experimental myocardial infarction produces antinatriuresis by a renal nerve dependent mechanism publication-title: Braz J Biol Res doi: 10.1590/S0100-879X2004000200017 contributor: fullname: Souza – volume: 344 start-page: 228 issue: 3 year: 2012 ident: 10.1016/j.amjms.2016.06.016_bib8 article-title: The kidney in heart failure: friend or foe? publication-title: Am J Med Sci doi: 10.1097/MAJ.0b013e318242a631 contributor: fullname: Kshatriya – volume: 16 start-page: 51 issue: 2 year: 2002 ident: 10.1016/j.amjms.2016.06.016_bib13 article-title: Effects of long-term renal sympathetic denervation on heart failure after myocardial infarction in rats publication-title: Heart Vessels doi: 10.1007/s380-002-8317-8 contributor: fullname: Nozawa – volume: 6 start-page: 224 year: 2015 ident: 10.1016/j.amjms.2016.06.016_bib11 article-title: The renal nerves in chronic heart failure: efferent and afferent mechanisms publication-title: Front Physiol doi: 10.3389/fphys.2015.00224 contributor: fullname: Schiller – volume: 10 start-page: 1525 issue: 10 year: 2013 ident: 10.1016/j.amjms.2016.06.016_bib12 article-title: Renal denervation suppresses ventricular arrhythmias during acute ventricular ischemia in pigs publication-title: Heart Rhythm doi: 10.1016/j.hrthm.2013.07.015 contributor: fullname: Linz – volume: 59 start-page: 901 year: 2012 ident: 10.1016/j.amjms.2016.06.016_bib14 article-title: Renal sympathetic denervation reduces left ventricular hypertrophy and improves cardiac function in patients with resistant hypertension publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2011.11.034 contributor: fullname: Brandt – volume: 373 start-page: 1275 year: 2009 ident: 10.1016/j.amjms.2016.06.016_bib15 article-title: Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study publication-title: Lancet doi: 10.1016/S0140-6736(09)60566-3 contributor: fullname: Krum – volume: 9 start-page: 209051 year: 2015 ident: 10.1016/j.amjms.2016.06.016_bib18 article-title: Peregrime system infusion catheter for perivascular renal denervation publication-title: J Med Dev contributor: fullname: Fischell – volume: 114 start-page: 1815 year: 2014 ident: 10.1016/j.amjms.2016.06.016_bib2 article-title: The autonomic nervous system and heart failure publication-title: Circ Res doi: 10.1161/CIRCRESAHA.114.302589 contributor: fullname: Florea – volume: 26 start-page: R1599 year: 1994 ident: 10.1016/j.amjms.2016.06.016_bib4 article-title: Effects of renal denervation on postprandial sodium excretion in experimental heart failure publication-title: Am J Physiol contributor: fullname: Villarreal – volume: 264 start-page: H1187 year: 1993 ident: 10.1016/j.amjms.2016.06.016_bib5 article-title: Neurohumoral modulators and sodium balance in experimental heart failure publication-title: Am J Physiol contributor: fullname: Villarreal |
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| SubjectTerms | Animals Cardiac peptides Diuresis Heart Failure - physiopathology Humans Internal Medicine Kidney - innervation Kidney - physiopathology Natriuresis Renal denervation Sympathectomy Sympathetic Nervous System - physiopathology |
| Title | Pathophysiologic Mechanisms in Heart Failure. Role of the Sympathetic Nervous System |
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