Epidemiology and preventability of hospital-onset bacteremia and fungemia in 2 hospitals in India

• Published in: Infection control and hospital epidemiology Vol. 45; no. 2; pp. 157 - 166
• Main Authors: Gandra, Sumanth, Singh, Sanjeev K., Chakravarthy, Murali, Moni, Merlin, Dhekane, Pruthu, Mohamed, Zubair, Shameen, Fathima, Vasudevan, Anil K., Senthil, Priyadarshini, Saravanan, Tejaswini, George, Anu, Sinclair, Dorothy, Stwalley, Dustin, van Rheenen, Jacaranda, Westercamp, Matthew, Smith, Rachel M., Leekha, Surbhi, Warren, David K.
• Format: Journal Article
• Language: English
• Published: New York, USA Cambridge University Press 01-02-2024
• Subjects: Accreditation; Arterial lines; Automation; Bacteremia - epidemiology; Bacteremia - prevention & control; Blood; Catheter-Related Infections - epidemiology; Catheterization, Central Venous; Coronaviruses; COVID-19; Cross Infection - epidemiology; Cross Infection - prevention & control; Data collection; Disease control; Disease prevention; Epidemiology; Fungemia - epidemiology; Fungemia - prevention & control; Health care; Hospitals; Humans; Medical instruments; Medical laboratories; Microbiology; Original; Original Article; Patient safety; Pediatrics; Retrospective Studies; Sepsis - epidemiology; Surgical site infections; France; United States > US; India
• ISSN: 0899-823X; 1559-6834
• DOI: 10.1017/ice.2023.170

Studies evaluating the incidence, source, and preventability of hospital-onset bacteremia and fungemia (HOB), defined as any positive blood culture obtained after 3 calendar days of hospital admission, are lacking in low- and middle-income countries (LMICs).
All consecutive blood cultures performed for 6 months during 2020-2021 in 2 hospitals in India were reviewed to assess HOB and National Healthcare Safety Network (NHSN) reportable central-line-associated bloodstream infection (CLABSI) events. Medical records of a convenience sample of 300 consecutive HOB events were retrospectively reviewed to determine source and preventability. Univariate and multivariable logistic regression analyses were performed to identify factors associated with HOB preventability.
Among 6,733 blood cultures obtained from 3,558 hospitalized patients, there were 409 and 59 unique HOB and NHSN-reportable CLABSI events, respectively. CLABSIs accounted for 59 (14%) of 409 HOB events. There was a moderate but non-significant correlation (r = 0.51;
= .070) between HOB and CLABSI rates. Among 300 reviewed HOB cases, CLABSIs were identified as source in only 38 (13%). Although 157 (52%) of all 300 HOB cases were potentially preventable, CLABSIs accounted for only 22 (14%) of these 157 preventable HOB events. In multivariable analysis, neutropenia, and sepsis as an indication for blood culture were associated with decreased odds of HOB preventability, whereas hospital stay ≥7 days and presence of a urinary catheter were associated with increased likelihood of preventability.
HOB may have utility as a healthcare-associated infection metric in LMIC settings because it captures preventable bloodstream infections beyond NHSN-reportable CLABSIs.