Oxidative Damage to DNA: Do We Have a Reliable Biomarker?

Oxidized bases in DNA can be measured directly by high-performance liquid chromatography (HPLC). 7,8-Dihydro-8-oxo-guanine (8-OHgua), as the most abundant oxidation product, is often regarded as an indicator of oxidative stress. Estimates of endogenous 8-OHgua levels in human lymphocyte DNA are betw...

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Bibliographic Details
Published in:	Environmental health perspectives Vol. 104; no. suppl 3; pp. 465 - 469
Main Authors:	Collins, Andrew R., Dušinská, Mária, Gedik, Catherine M., Štětina, Rudolf
Format:	Journal Article
Language:	English
Published:	United States National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare 01-05-1996
Subjects:	Adult Biomarkers Biomarkers of Exposure and Effects of Mutagens and Carcinogens Chemical bases Chromatography, High Pressure Liquid Comets Deoxyguanosine - analogs & derivatives Deoxyguanosine - analysis DNA DNA Damage DNA-Formamidopyrimidine Glycosylase Earthquake damage Electrophoresis, Agar Gel Endonucleases - metabolism Enzymes HeLa Cells Humans Hydrogen Peroxide - pharmacology Lymphocytes Lymphocytes - metabolism Male Middle Aged N-Glycosyl Hydrolases - metabolism Oxidation Oxidation-Reduction Radiation damage
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