Fluconazole Doses Used for Prophylaxis of Invasive Fungal Infection in Neonatal Intensive Care Units: A Network Meta-Analysis

Objectives To evaluate the safety and efficacy of different doses of fluconazole used for invasive prophylaxis of fungal infection in neonates. Study design A systematic search was conducted with PubMed, Scopus, and Web of Science. A manual search was performed as well. Only randomized controlled tr...

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Bibliographic Details
Published in:	The Journal of pediatrics Vol. 185; pp. 129 - 135.e6
Main Authors:	Leonart, Letícia Paula, MSc, Tonin, Fernanda Stumpf, MSc, Ferreira, Vinicius Lins, MSc, Tavares da Silva Penteado, Suelem, MSc, de Araújo Motta, Fábio, PhD, Pontarolo, Roberto, PhD
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-06-2017
Subjects:	Antifungal Agents - administration & dosage Candidiasis, Invasive - prevention & control dose Dose-Response Relationship, Drug fluconazole Fluconazole - administration & dosage Humans Intensive Care Units, Neonatal neonate, preterm infant Network Meta-Analysis Pediatrics prophylaxis RCT Invasive candidiasis VLBW Very low birth weight Invasive fungal infection NICU prophylaxis IFI Randomized controlled trial Pharmacokinetic fluconazole dose Neonatal intensive care unit Credible interval IC CrI PK neonate, preterm infant
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