Oxidative stress markers and lipid profiles of patients with polycystic ovary syndrome in a Nigerian tertiary hospital

• Published in: Obstetrics & gynecology science Vol. 62; no. 5; pp. 335 - 343
• Main Authors: Enechukwu, Chukwunonso Isaiah, Onuegbu, Anaelechi Jude, Olisekodiaka, Madu Japheth, Eleje, George Uchenna, Ikechebelu, Joseph Ifeanyichukwu, Ugboaja, Joseph Odirichukwu, Amah, Ubuo Kalu, Okwara, John Ekenedirichukwu, Igwegbe, Anthony Osita
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society 01-09-2019; Korean Society of Obstetrics and Gynecology; 대한산부인과학회
• Subjects: cardiometabolic risks; dyslipidaemia; obesity; Original; oxidative stress; polycystic ovary syndrome; 산부인과학; Obesity; Oxidative stress; Polycystic ovary syndrome; Dyslipidaemia; Cardiometabolic risks
• ISSN: 2287-8572; 2287-8580
• DOI: 10.5468/ogs.2019.62.5.335

To determine the activities of oxidative stress markers and lipid profiles of patients with polycystic ovary syndrome (PCOS) in Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria.
This was a nested case-control study consisting of 50 PCOS patients and 50 healthy women of the same age range without any evidence of PCOS. The study measured the levels of malondialdehyde (MDA), activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), total antioxidant capacity (TAC); concentrations of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C), as well as high-density lipoprotein cholesterol (HDL-C) using standard spectrophotometric methods. Anthropometric indices were also assessed.
-values of <0.05 were taken to be statistically significant.
There were significantly higher levels of MDA (
=0.002), lower activity of SOD (
<0.001), and lower TAC (
=0.001) in PCOS patients when compared with the controls. There were higher concentrations of TC (
=0.017) and LDL-C
=0.012) in PCOS patients than in controls. Significant differences were not observed between the 2 groups in terms of the activity of GSH-Px, as well as the concentrations of HDL-C and TG. The body mass index, waist circumference, and waist-hip ratio were all significantly higher in PCOS patients.
This study revealed higher levels of MDA, as well as lower activity of SOD and TAC, among PCOS patients. Furthermore, there were higher levels of TC and LDL-C among the PCOS patients. Hence, monitoring these parameters may improve the clinical management of PCOS.