Riboswitches: natural SELEXion

Advances in our knowledge of the structure and chemistry of RNA have been harnessed in the process known as SELEX to develop artificial RNA-based molecules that can act as enzymes and ligand binders performing a wide variety of functions. The discovery of riboswitches, natural RNA aptamers involved...

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Bibliographic Details
Published in:	Cellular and molecular life sciences : CMLS Vol. 62; no. 21; pp. 2401 - 2404
Main Authors:	Gilbert, S D, Batey, R T
Format:	Journal Article
Language:	English
Published:	Switzerland Springer Nature B.V 01-11-2005 Birkhäuser-Verlag
Subjects:	Aptamers, Nucleotide - metabolism Binders Enzymes Molecules Nucleic Acid Conformation Ribonucleic acid RNA RNA - chemistry RNA - metabolism SELEX Aptamer Technique Visions & Reflections
Online Access:	Get full text
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Summary:	Advances in our knowledge of the structure and chemistry of RNA have been harnessed in the process known as SELEX to develop artificial RNA-based molecules that can act as enzymes and ligand binders performing a wide variety of functions. The discovery of riboswitches, natural RNA aptamers involved in genetic regulation, offers a basis of comparison between the artificial selection and the natural selection of structured RNAs for small-molecule recognition. The guanine riboswitch structural determination allows us to draw conclusions regarding the apparent increased complexity of the riboswitch aptamers compared to their in-vitro-selected cousins.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1420-682X 1420-9071
DOI:	10.1007/s00018-005-5345-3