Yacon supplementation reduces serum free fatty acids and tumor necrosis factor alpha concentrations in patients with type 2 diabetes

Yacon is a perennial plant originating from South America that forms >20 large subterranean tubers weighing from 100 to 500 g. These tubers have become popular in Japan and contain beta-1, 2-oligofructans as the main saccharides. Preliminary work in animals revealed yacon feeding ameliorates diab...

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Published in:	Diabetology international Vol. 5; no. 3; pp. 165 - 174
Main Authors:	Satoh, Hiroaki, Kudoh, Akihiro, Hasegawa, Koji, Hirai, Hiroyuki, Watanabe, Tsuyoshi
Format:	Journal Article
Language:	English
Published:	Tokyo Springer Japan 01-09-2014
Subjects:	Diabetes Endocrinology Medicine Medicine & Public Health Metabolic Diseases Original Article Type 2 diabetes Yacon TNF-α Free fatty acids
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Abstract	Yacon is a perennial plant originating from South America that forms >20 large subterranean tubers weighing from 100 to 500 g. These tubers have become popular in Japan and contain beta-1, 2-oligofructans as the main saccharides. Preliminary work in animals revealed yacon feeding ameliorates diabetes by reducing blood glucose. We therefore examined whether yacon feeding modulates glucose metabolism in patients with type 2 diabetes. We conducted a single-center, open-label, randomized controlled trial to investigate the effect of yacon on patients with type 2 diabetes. Fifty-eight patients with type 2 diabetes were selected from the medical outpatients department. There had been no changes in their diet or medications during the 3 months before the study commenced. After ethical clearance, written informed consent was obtained. Patients were randomly assigned to two groups: group 1 received an intake level of 100 g yacon/day, and group 2 received an intake level of 100 g aroid/day (control). Fasting glucose, insulin, glycated albumin, and adiponectin concentrations at baseline did not differ significantly between groups; after 5 months, concentrations did not change significantly in either group. Interestingly, after 5 months of yacon consumption, tumor necrosis factor alpha (TNF-α) and free fatty acid (FFA) concentrations decreased significantly by 10.3 % and 9.8 % ( p < 0.01), respectively; neither changed significantly in the aroid group. In conclusion, the results suggest longer-term yacon supplementation may improve insulin resistance by reducing FFA and TNF-α in patients with type 2 diabetes.
AbstractList	Yacon is a perennial plant originating from South America that forms >20 large subterranean tubers weighing from 100 to 500 g. These tubers have become popular in Japan and contain beta-1, 2-oligofructans as the main saccharides. Preliminary work in animals revealed yacon feeding ameliorates diabetes by reducing blood glucose. We therefore examined whether yacon feeding modulates glucose metabolism in patients with type 2 diabetes. We conducted a single-center, open-label, randomized controlled trial to investigate the effect of yacon on patients with type 2 diabetes. Fifty-eight patients with type 2 diabetes were selected from the medical outpatients department. There had been no changes in their diet or medications during the 3 months before the study commenced. After ethical clearance, written informed consent was obtained. Patients were randomly assigned to two groups: group 1 received an intake level of 100 g yacon/day, and group 2 received an intake level of 100 g aroid/day (control). Fasting glucose, insulin, glycated albumin, and adiponectin concentrations at baseline did not differ significantly between groups; after 5 months, concentrations did not change significantly in either group. Interestingly, after 5 months of yacon consumption, tumor necrosis factor alpha (TNF-α) and free fatty acid (FFA) concentrations decreased significantly by 10.3 % and 9.8 % ( p < 0.01), respectively; neither changed significantly in the aroid group. In conclusion, the results suggest longer-term yacon supplementation may improve insulin resistance by reducing FFA and TNF-α in patients with type 2 diabetes.
Author	Satoh, Hiroaki Watanabe, Tsuyoshi Kudoh, Akihiro Hasegawa, Koji Hirai, Hiroyuki
Author_xml	– sequence: 1 givenname: Hiroaki surname: Satoh fullname: Satoh, Hiroaki email: hiroakis-tky@umin.ac.jp organization: Department of Nephrology, Hypertension, Diabetology, Endocrinology, and Metabolism, Fukushima Medical University – sequence: 2 givenname: Akihiro surname: Kudoh fullname: Kudoh, Akihiro organization: Department of Nephrology, Hypertension, Diabetology, Endocrinology, and Metabolism, Fukushima Medical University – sequence: 3 givenname: Koji surname: Hasegawa fullname: Hasegawa, Koji organization: Department of Nephrology, Hypertension, Diabetology, Endocrinology, and Metabolism, Fukushima Medical University – sequence: 4 givenname: Hiroyuki surname: Hirai fullname: Hirai, Hiroyuki organization: Department of Nephrology, Hypertension, Diabetology, Endocrinology, and Metabolism, Fukushima Medical University – sequence: 5 givenname: Tsuyoshi surname: Watanabe fullname: Watanabe, Tsuyoshi organization: Department of Nephrology, Hypertension, Diabetology, Endocrinology, and Metabolism, Fukushima Medical University
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Cites_doi	10.2337/db07-1403 10.2337/diab.46.1.3 10.2337/diabetes.54.8.2404 10.1007/BF00280883 10.1021/jf0344744 10.1021/jf981305o 10.1023/A:1006865715292 10.1126/science.7678183 10.1016/j.smim.2011.11.011 10.1172/JCI20785 10.1038/nature01137 10.4172/2155-6156.1000230 10.1186/1476-511X-10-126 10.1177/0115426505020002244 10.1161/ATVBAHA.111.241919 10.1016/j.cmet.2007.06.003 10.1056/NEJMoa012512 10.1159/000155214 10.1074/jbc.M200958200 10.2337/diabetes.54.5.1304 10.1074/jbc.M207198200 10.1038/39335 10.2337/diabetes.52.8.1935 10.1152/ajpgi.00173.2003 10.1017/S0007114512004230 10.5507/bp.2003.017 10.1016/j.clnu.2009.01.013 10.2337/diabetes.50.8.1901 10.1073/pnas.91.11.4854 10.1152/ajpgi.00318.2005 10.1016/S0021-9258(18)54714-1 10.1016/S0021-9258(19)74276-8 10.1210/endo.137.6.8641197
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References	Matthews, Hosker, Rudenski, Naylor, Treacher, Turner (CR13) 1985; 28 Stephens, Pekala (CR22) 1991; 266 Pajvani, Du, Combs, Berg, Rajala, Schulthess, Engel, Brownlee, Scherer (CR4) 2003; 278 Satoh, Nguyen, Trujillo, Imamura, Usui, Scherer, Olefsky (CR2) 2005; 54 Feinstein, Kanety, Papa, Lunenfeld, Karasik (CR24) 1993; 268 Begum, Ragolia (CR25) 1996; 137 Uysal, Wiesbrock, Marino, Hotamisligil (CR20) 1997; 389 Hirosumi, Tuncman, Chang, Gorgun, Uysal, Maeda, Karin, Hotamisligil (CR16) 2002; 420 Ye, Ma, Ma (CR31) 2006; 290 Kubota, Yano, Kubota, Yamauchi, Itoh, Kumagai, Kozono, Takamoto, Okamoto, Shiuchi, Suzuki, Satoh, Tsuchida, Moroi, Sugi, Noda, Ebinuma, Ueta, Kondo, Araki, Ezaki, Nagai, Tobe, Terauchi, Ueki, Minokoshi, Kadowaki (CR5) 2007; 6 Burcelin, Garidou, Pomie (CR33) 2012; 24 Bengmark, Martindale (CR27) 2005; 20 Hotamisligil, Shargill, Spiegelman (CR23) 1993; 259 Machii, Satoh, Kudoh, Watanabe (CR6) 2012; 3 Rask-Madsen, Kahn (CR1) 2012; 32 Knowler, Barrett-Connor, Fowler, Hamman, Lachin, Walker, Nathan (CR7) 2002; 346 Kim, Kotani, Ciaraldi, Henry, Kahn (CR18) 2003; 52 Tremblay, Lavigne, Jacques, Marette (CR17) 2001; 50 Kitabchi, Temprosa, Knowler, Kahn, Fowler, Haffner, Andres, Saudek, Edelstein, Arakaki, Murphy, Shamoon (CR8) 2005; 54 Cavallini, Suzuki, Abdalla, Vendramini, Pauly-Silveira, Roselino, Pinto, Rossi (CR28) 2011; 10 Genta, Cabrera, Habib, Pons, Carillo, Grau, Sanchez (CR12) 2009; 28 Valentova, Ulrichova (CR9) 2003; 147 Cani, Bibiloni, Knauf, Waget, Neyrinck, Delzenne, Burcelin (CR29) 2008; 57 Yu, Chen, Cline, Zhang, Zong, Wang, Bergeron, Kim, Cushman, Cooney, Atcheson, White, Kraegen, Shulman (CR15) 2002; 277 Ma, Iwamoto, Hoa, Akotia, Pedram, Boivin, Said (CR30) 2004; 286 Satoh, Nguyen, Miles, Imamura, Usui, Olefsky (CR3) 2004; 114 Pedreschi, Campos, Noratto, Chirinos, Cisneros-Zevallos (CR26) 2003; 51 Geyer, Manrique, Degen, Beglinger (CR11) 2008; 78 Boden (CR14) 1997; 46 Peraldi, Spiegelman (CR19) 1998; 182 Hotamisligil, Murray, Choy, Spiegelman (CR21) 1994; 91 Velez, Castillo, Meson, Grau, Bibas Bonet, Perdigon (CR32) 2013; 109 Yan, Suzuki, Ohnishi-Kameyama, Sada, Nakanishi, Nagata (CR10) 1999; 47 YB Kim (150_CR18) 2003; 52 GS Hotamisligil (150_CR21) 1994; 91 C Yu (150_CR15) 2002; 277 KT Uysal (150_CR20) 1997; 389 JM Stephens (150_CR22) 1991; 266 R Burcelin (150_CR33) 2012; 24 C Rask-Madsen (150_CR1) 2012; 32 N Kubota (150_CR5) 2007; 6 S Bengmark (150_CR27) 2005; 20 N Begum (150_CR25) 1996; 137 N Machii (150_CR6) 2012; 3 UB Pajvani (150_CR4) 2003; 278 GS Hotamisligil (150_CR23) 1993; 259 PD Cani (150_CR29) 2008; 57 P Peraldi (150_CR19) 1998; 182 AE Kitabchi (150_CR8) 2005; 54 R Pedreschi (150_CR26) 2003; 51 H Satoh (150_CR2) 2005; 54 G Boden (150_CR14) 1997; 46 WC Knowler (150_CR7) 2002; 346 K Valentova (150_CR9) 2003; 147 DR Matthews (150_CR13) 1985; 28 J Hirosumi (150_CR16) 2002; 420 D Ye (150_CR31) 2006; 290 DC Cavallini (150_CR28) 2011; 10 TY Ma (150_CR30) 2004; 286 M Geyer (150_CR11) 2008; 78 F Tremblay (150_CR17) 2001; 50 X Yan (150_CR10) 1999; 47 S Genta (150_CR12) 2009; 28 R Feinstein (150_CR24) 1993; 268 H Satoh (150_CR3) 2004; 114 E Velez (150_CR32) 2013; 109
References_xml	– volume: 57 start-page: 1470 year: 2008 end-page: 1481 ident: CR29 article-title: Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice publication-title: Diabetes doi: 10.2337/db07-1403 contributor: fullname: Burcelin – volume: 266 start-page: 21839 year: 1991 end-page: 21845 ident: CR22 article-title: Transcriptional repression of the glut4 and c/ebp genes in 3t3-l1 adipocytes by tumor necrosis factor-alpha publication-title: J Biol Chem contributor: fullname: Pekala – volume: 46 start-page: 3 year: 1997 end-page: 10 ident: CR14 article-title: Role of fatty acids in the pathogenesis of insulin resistance and niddm publication-title: Diabetes doi: 10.2337/diab.46.1.3 contributor: fullname: Boden – volume: 54 start-page: 2404 year: 2005 end-page: 2414 ident: CR8 article-title: Role of insulin secretion and sensitivity in the evolution of type 2 diabetes in the diabetes prevention program: effects of lifestyle intervention and metformin publication-title: Diabetes doi: 10.2337/diabetes.54.8.2404 contributor: fullname: Shamoon – volume: 28 start-page: 412 year: 1985 end-page: 419 ident: CR13 article-title: Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man publication-title: Diabetologia doi: 10.1007/BF00280883 contributor: fullname: Turner – volume: 51 start-page: 5278 year: 2003 end-page: 5284 ident: CR26 article-title: Andean yacon root (smallanthus sonchifolius poepp. Endl) fructooligosaccharides as a potential novel source of prebiotics publication-title: J Agric Food Chem doi: 10.1021/jf0344744 contributor: fullname: Cisneros-Zevallos – volume: 268 start-page: 26055 year: 1993 end-page: 26058 ident: CR24 article-title: Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates publication-title: J Biol Chem contributor: fullname: Karasik – volume: 47 start-page: 4711 year: 1999 end-page: 4713 ident: CR10 article-title: Extraction and identification of antioxidants in the roots of yacon (smallanthus sonchifolius) publication-title: J Agric Food Chem doi: 10.1021/jf981305o contributor: fullname: Nagata – volume: 182 start-page: 169 year: 1998 end-page: 175 ident: CR19 article-title: Tnf-alpha and insulin resistance: summary and future prospects publication-title: Mol Cell Biochem doi: 10.1023/A:1006865715292 contributor: fullname: Spiegelman – volume: 259 start-page: 87 year: 1993 end-page: 91 ident: CR23 article-title: Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance publication-title: Science doi: 10.1126/science.7678183 contributor: fullname: Spiegelman – volume: 24 start-page: 67 year: 2012 end-page: 74 ident: CR33 article-title: Immuno-microbiota cross and talk: the new paradigm of metabolic diseases publication-title: Semin Immunol doi: 10.1016/j.smim.2011.11.011 contributor: fullname: Pomie – volume: 114 start-page: 224 year: 2004 end-page: 231 ident: CR3 article-title: Adenovirus-mediated chronic “hyper-resistinemia” leads to in vivo insulin resistance in normal rats publication-title: J Clin Invest doi: 10.1172/JCI20785 contributor: fullname: Olefsky – volume: 420 start-page: 333 year: 2002 end-page: 336 ident: CR16 article-title: A central role for jnk in obesity and insulin resistance publication-title: Nature doi: 10.1038/nature01137 contributor: fullname: Hotamisligil – volume: 137 start-page: 2441 year: 1996 end-page: 2446 ident: CR25 article-title: Effect of tumor necrosis factor-alpha on insulin action in cultured rat skeletal muscle cells publication-title: Endocrinology contributor: fullname: Ragolia – volume: 3 start-page: 230 year: 2012 ident: CR6 article-title: Resistin exacerbates insulin resistance under the condition of low adiponectin in 3t3-l1 adipocytes publication-title: J Diabetes Metab doi: 10.4172/2155-6156.1000230 contributor: fullname: Watanabe – volume: 10 start-page: 126 year: 2011 ident: CR28 article-title: Influence of a probiotic soy product on fecal microbiota and its association with cardiovascular risk factors in an animal model publication-title: Lipids Health Dis doi: 10.1186/1476-511X-10-126 contributor: fullname: Rossi – volume: 20 start-page: 244 year: 2005 end-page: 261 ident: CR27 article-title: Prebiotics and synbiotics in clinical medicine publication-title: Nutr Clin Pract doi: 10.1177/0115426505020002244 contributor: fullname: Martindale – volume: 32 start-page: 2052 year: 2012 end-page: 2059 ident: CR1 article-title: Tissue-specific insulin signaling, metabolic syndrome, and cardiovascular disease publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.111.241919 contributor: fullname: Kahn – volume: 6 start-page: 55 year: 2007 end-page: 68 ident: CR5 article-title: Adiponectin stimulates amp-activated protein kinase in the hypothalamus and increases food intake publication-title: Cell Metab doi: 10.1016/j.cmet.2007.06.003 contributor: fullname: Kadowaki – volume: 346 start-page: 393 year: 2002 end-page: 403 ident: CR7 article-title: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin publication-title: N Engl J Med doi: 10.1056/NEJMoa012512 contributor: fullname: Nathan – volume: 78 start-page: 30 year: 2008 end-page: 33 ident: CR11 article-title: Effect of yacon (smallanthus sonchifolius) on colonic transit time in healthy volunteers publication-title: Digestion doi: 10.1159/000155214 contributor: fullname: Beglinger – volume: 277 start-page: 50230 year: 2002 end-page: 50236 ident: CR15 article-title: Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (irs-1)-associated phosphatidylinositol 3-kinase activity in muscle publication-title: J Biol Chem doi: 10.1074/jbc.M200958200 contributor: fullname: Shulman – volume: 54 start-page: 1304 year: 2005 end-page: 1313 ident: CR2 article-title: Adenovirus-mediated adiponectin expression augments skeletal muscle insulin sensitivity in male wistar rats publication-title: Diabetes doi: 10.2337/diabetes.54.5.1304 contributor: fullname: Olefsky – volume: 278 start-page: 9073 year: 2003 end-page: 9085 ident: CR4 article-title: Structure-function studies of the adipocyte-secreted hormone acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity publication-title: J Biol Chem doi: 10.1074/jbc.M207198200 contributor: fullname: Scherer – volume: 389 start-page: 610 year: 1997 end-page: 614 ident: CR20 article-title: Protection from obesity-induced insulin resistance in mice lacking tnf-alpha function publication-title: Nature doi: 10.1038/39335 contributor: fullname: Hotamisligil – volume: 52 start-page: 1935 year: 2003 end-page: 1942 ident: CR18 article-title: Insulin-stimulated protein kinase c lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: reversal with weight reduction publication-title: Diabetes doi: 10.2337/diabetes.52.8.1935 contributor: fullname: Kahn – volume: 286 start-page: G367 year: 2004 end-page: G376 ident: CR30 article-title: Tnf-alpha-induced increase in intestinal epithelial tight junction permeability requires nf-kappa b activation publication-title: Am J Physiol Gastrointest Liver Physiol doi: 10.1152/ajpgi.00173.2003 contributor: fullname: Said – volume: 109 start-page: 1971 year: 2013 end-page: 1979 ident: CR32 article-title: Study of the effect exerted by fructo-oligosaccharides from yacon (smallanthus sonchifolius) root flour in an intestinal infection model with salmonella typhimurium publication-title: Br J Nutr doi: 10.1017/S0007114512004230 contributor: fullname: Perdigon – volume: 147 start-page: 119 year: 2003 end-page: 130 ident: CR9 article-title: Smallanthus sonchifolius and lepidium meyenii - prospective andean crops for the prevention of chronic diseases publication-title: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub doi: 10.5507/bp.2003.017 contributor: fullname: Ulrichova – volume: 28 start-page: 182 year: 2009 end-page: 187 ident: CR12 article-title: Yacon syrup: beneficial effects on obesity and insulin resistance in humans publication-title: Clin Nutr doi: 10.1016/j.clnu.2009.01.013 contributor: fullname: Sanchez – volume: 50 start-page: 1901 year: 2001 end-page: 1910 ident: CR17 article-title: Defective insulin-induced glut4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both akt/protein kinase b and atypical protein kinase c (zeta/lambda) activities publication-title: Diabetes doi: 10.2337/diabetes.50.8.1901 contributor: fullname: Marette – volume: 91 start-page: 4854 year: 1994 end-page: 4858 ident: CR21 article-title: Tumor necrosis factor alpha inhibits signaling from the insulin receptor publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.91.11.4854 contributor: fullname: Spiegelman – volume: 290 start-page: G496 year: 2006 end-page: G504 ident: CR31 article-title: Molecular mechanism of tumor necrosis factor-alpha modulation of intestinal epithelial tight junction barrier publication-title: Am J Physiol Gastrointest Liver Physiol doi: 10.1152/ajpgi.00318.2005 contributor: fullname: Ma – volume: 46 start-page: 3 year: 1997 ident: 150_CR14 publication-title: Diabetes doi: 10.2337/diab.46.1.3 contributor: fullname: G Boden – volume: 109 start-page: 1971 year: 2013 ident: 150_CR32 publication-title: Br J Nutr doi: 10.1017/S0007114512004230 contributor: fullname: E Velez – volume: 277 start-page: 50230 year: 2002 ident: 150_CR15 publication-title: J Biol Chem doi: 10.1074/jbc.M200958200 contributor: fullname: C Yu – volume: 278 start-page: 9073 year: 2003 ident: 150_CR4 publication-title: J Biol Chem doi: 10.1074/jbc.M207198200 contributor: fullname: UB Pajvani – volume: 28 start-page: 182 year: 2009 ident: 150_CR12 publication-title: Clin Nutr doi: 10.1016/j.clnu.2009.01.013 contributor: fullname: S Genta – volume: 54 start-page: 1304 year: 2005 ident: 150_CR2 publication-title: Diabetes doi: 10.2337/diabetes.54.5.1304 contributor: fullname: H Satoh – volume: 266 start-page: 21839 year: 1991 ident: 150_CR22 publication-title: J Biol Chem doi: 10.1016/S0021-9258(18)54714-1 contributor: fullname: JM Stephens – volume: 346 start-page: 393 year: 2002 ident: 150_CR7 publication-title: N Engl J Med doi: 10.1056/NEJMoa012512 contributor: fullname: WC Knowler – volume: 24 start-page: 67 year: 2012 ident: 150_CR33 publication-title: Semin Immunol doi: 10.1016/j.smim.2011.11.011 contributor: fullname: R Burcelin – volume: 6 start-page: 55 year: 2007 ident: 150_CR5 publication-title: Cell Metab doi: 10.1016/j.cmet.2007.06.003 contributor: fullname: N Kubota – volume: 50 start-page: 1901 year: 2001 ident: 150_CR17 publication-title: Diabetes doi: 10.2337/diabetes.50.8.1901 contributor: fullname: F Tremblay – volume: 52 start-page: 1935 year: 2003 ident: 150_CR18 publication-title: Diabetes doi: 10.2337/diabetes.52.8.1935 contributor: fullname: YB Kim – volume: 32 start-page: 2052 year: 2012 ident: 150_CR1 publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.111.241919 contributor: fullname: C Rask-Madsen – volume: 47 start-page: 4711 year: 1999 ident: 150_CR10 publication-title: J Agric Food Chem doi: 10.1021/jf981305o contributor: fullname: X Yan – volume: 28 start-page: 412 year: 1985 ident: 150_CR13 publication-title: Diabetologia doi: 10.1007/BF00280883 contributor: fullname: DR Matthews – volume: 54 start-page: 2404 year: 2005 ident: 150_CR8 publication-title: Diabetes doi: 10.2337/diabetes.54.8.2404 contributor: fullname: AE Kitabchi – volume: 259 start-page: 87 year: 1993 ident: 150_CR23 publication-title: Science doi: 10.1126/science.7678183 contributor: fullname: GS Hotamisligil – volume: 268 start-page: 26055 year: 1993 ident: 150_CR24 publication-title: J Biol Chem doi: 10.1016/S0021-9258(19)74276-8 contributor: fullname: R Feinstein – volume: 182 start-page: 169 year: 1998 ident: 150_CR19 publication-title: Mol Cell Biochem doi: 10.1023/A:1006865715292 contributor: fullname: P Peraldi – volume: 114 start-page: 224 year: 2004 ident: 150_CR3 publication-title: J Clin Invest doi: 10.1172/JCI20785 contributor: fullname: H Satoh – volume: 78 start-page: 30 year: 2008 ident: 150_CR11 publication-title: Digestion doi: 10.1159/000155214 contributor: fullname: M Geyer – volume: 286 start-page: G367 year: 2004 ident: 150_CR30 publication-title: Am J Physiol Gastrointest Liver Physiol doi: 10.1152/ajpgi.00173.2003 contributor: fullname: TY Ma – volume: 91 start-page: 4854 year: 1994 ident: 150_CR21 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.91.11.4854 contributor: fullname: GS Hotamisligil – volume: 51 start-page: 5278 year: 2003 ident: 150_CR26 publication-title: J Agric Food Chem doi: 10.1021/jf0344744 contributor: fullname: R Pedreschi – volume: 420 start-page: 333 year: 2002 ident: 150_CR16 publication-title: Nature doi: 10.1038/nature01137 contributor: fullname: J Hirosumi – volume: 137 start-page: 2441 year: 1996 ident: 150_CR25 publication-title: Endocrinology doi: 10.1210/endo.137.6.8641197 contributor: fullname: N Begum – volume: 290 start-page: G496 year: 2006 ident: 150_CR31 publication-title: Am J Physiol Gastrointest Liver Physiol doi: 10.1152/ajpgi.00318.2005 contributor: fullname: D Ye – volume: 57 start-page: 1470 year: 2008 ident: 150_CR29 publication-title: Diabetes doi: 10.2337/db07-1403 contributor: fullname: PD Cani – volume: 3 start-page: 230 year: 2012 ident: 150_CR6 publication-title: J Diabetes Metab doi: 10.4172/2155-6156.1000230 contributor: fullname: N Machii – volume: 389 start-page: 610 year: 1997 ident: 150_CR20 publication-title: Nature doi: 10.1038/39335 contributor: fullname: KT Uysal – volume: 20 start-page: 244 year: 2005 ident: 150_CR27 publication-title: Nutr Clin Pract doi: 10.1177/0115426505020002244 contributor: fullname: S Bengmark – volume: 147 start-page: 119 year: 2003 ident: 150_CR9 publication-title: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub doi: 10.5507/bp.2003.017 contributor: fullname: K Valentova – volume: 10 start-page: 126 year: 2011 ident: 150_CR28 publication-title: Lipids Health Dis doi: 10.1186/1476-511X-10-126 contributor: fullname: DC Cavallini
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Snippet	Yacon is a perennial plant originating from South America that forms >20 large subterranean tubers weighing from 100 to 500 g. These tubers have become popular...
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SubjectTerms	Diabetes Endocrinology Medicine Medicine & Public Health Metabolic Diseases Original Article
Title	Yacon supplementation reduces serum free fatty acids and tumor necrosis factor alpha concentrations in patients with type 2 diabetes
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