Gender differences for coronary angioplasty

• Published in: The American journal of cardiology Vol. 74; no. 1; pp. 18 - 21
• Main Authors: Arnold, Anita M., Mick, Matthew J., Piedmonte, Marion R., Simpfendorfer, Conrad
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01-07-1994; Elsevier; Elsevier Limited
• Subjects: Adult; Aged; Aged, 80 and over; Angioplasty; Angioplasty, Balloon, Coronary - adverse effects; Angioplasty, Balloon, Coronary - mortality; Biological and medical sciences; Body Constitution; Cardiovascular disease; Diseases of the cardiovascular system; Female; Follow-Up Studies; Humans; Male; Medical research; Medical sciences; Middle Aged; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Reoperation - statistics & numerical data; Risk Factors; Sex Characteristics; Sex Factors; Sexes; Survival Analysis; Treatment Outcome; Human; Prognosis; Coronary artery; Sex; Instrumentation therapy; Cuffed tube; Instrumental dilatation; Survival; Comparative study; Percutaneous route
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/0002-9149(94)90484-7

To determine if differences in early and late outcome after angioplasty were related to gender or body surface area, 5,000 consecutive patients (1,274 women and 3,726 men) were studied. Baseline variables, procedural outcome, and long-term and event-free survival were assessed. Baseline variables included age, history of hypertension, diabetes mellitus, heart failure, myocardial infarction, prior angioplasty or bypass surgery, familial coronary disease, Canadian heart classification, extent of angioplasty, left ventricular function, and body surface area. Overall and event-free survival (freedom from infarction, repeat angioplasty, bypass surgery and death) were assessed at follow-up. The results showed that, compared with men, women were older (p <0.0001), had a higher prevalence of diabetes (p <0.0001), familial coronary disease (p = 0.002), hypertension (p <0.0001), prior infarction (p s 0.004), and more involvement of the anterior descending artery (p = 0.017). Whereas men had similar extents of angioplasty and worse left ventricular function (p = 0.012), women more often had unstable angina (p <0.0001). The success rates were similar, yet women had a higher procedural mortality (1.1% women, 0.3% men, p = 0.001). When corrected for body surface area, however, women were at no greater risk than men. Follow-up was complete for 97.4% of patients (mean 4 ± 2 years). Event-free survival was significantly better in women, even after correcting for body surface area. Men were at higher risk for late death and repeat angioplasty on follow-up. It is concluded that women are not at higher risk for procedure-related mortality when compared with men, and their overall and event-free survival surpassed that of men. In this respect, the “gender difference” favors women.