jumonji gene is essential for the neurulation and cardiac development of mouse embryos with a C3H/He background

The recessive mutant mouse jumonji ( jmj), obtained by a gene trap strategy, shows neural tube defects in approximately half of homozygous embryos with a BALB/cA and 129/Ola mixed background, but no neural tube defects with BALB/cA, C57BL/6J, and DBA/2J backgrounds. Here, we show that neural tube an...

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Bibliographic Details
Published in:	Mechanisms of development Vol. 86; no. 1; pp. 29 - 38
Main Authors:	Takeuchi, Takashi, Kojima, Mizuyo, Nakajima, Kuniko, Kondo, Shunzo
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 01-08-1999
Subjects:	Animals Bulbus cordis Cardiac defects Cardiac myocytes Cell proliferation Disease Models, Animal Gene Expression Regulation, Developmental Gene trap Heart - embryology Heart Defects, Congenital - genetics Heart Defects, Congenital - pathology Heart Defects, Congenital - veterinary Heart morphogenesis Heart Ventricles - metabolism Homozygote jumonji Mice Mice, Inbred BALB C Mice, Inbred C3H - genetics Mice, Mutant Strains Myocardium - cytology Myocardium - pathology Myogenesis Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neural plate Neural tube defects Neural Tube Defects - genetics Neural Tube Defects - veterinary Neurulation Phenotype Polycomb Repressive Complex 2 Rodent Diseases - genetics Ventricular trabeculae Cell proliferation Ventricular trabeculae Heart morphogenesis Neural tube defects Bulbus cordis Gene trap Neural plate Cardiac defects Neurulation Cardiac myocytes Myogenesis jumonji
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