jumonji gene is essential for the neurulation and cardiac development of mouse embryos with a C3H/He background
The recessive mutant mouse jumonji ( jmj), obtained by a gene trap strategy, shows neural tube defects in approximately half of homozygous embryos with a BALB/cA and 129/Ola mixed background, but no neural tube defects with BALB/cA, C57BL/6J, and DBA/2J backgrounds. Here, we show that neural tube an...
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| Published in: | Mechanisms of development Vol. 86; no. 1; pp. 29 - 38 |
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| Main Authors: | , , , |
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| Language: | English |
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01-08-1999
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| Abstract | The recessive mutant mouse
jumonji (
jmj), obtained by a gene trap strategy, shows neural tube defects in approximately half of homozygous embryos with a BALB/cA and 129/Ola mixed background, but no neural tube defects with BALB/cA, C57BL/6J, and DBA/2J backgrounds. Here, we show that neural tube and cardiac defects are observed in all embryos with a C3H/HeJ background. In addition, abnormal groove formation and prominent flexure are observed on the neural plate with full penetrance, suggesting that abnormal groove formation leads to neural tube defects. We found morphogenetic abnormalities in the bulbus cordis (future outflow tract and the right ventricle) of homozygous embryo hearts. Moreover, myocytes in the ventricular trabeculae show hyperplasia with cells filling the ventricles. Together with the observation that the
jmj gene is expressed in the neural epithelium of the head neural plate and in myocytes in the bulbus cordis and trabeculae, the results show that the
jmj gene plays essential roles in the normal development of the neural plate, morphogenesis of bulbus cordis, and proliferation of trabecular myocytes on a C3H/He background. |
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| AbstractList | The recessive mutant mouse jumonji (jmj), obtained by a gene trap strategy, shows neural tube defects in approximately half of homozygous embryos with a BALB/cA and 129/Ola mixed background, but no neural tube defects with BALB/cA, C57BL/6J, and DBA/2J backgrounds. Here, we show that neural tube and cardiac defects are observed in all embryos with a C3H/HeJ background. In addition, abnormal groove formation and prominent flexure are observed on the neural plate with full penetrance, suggesting that abnormal groove formation leads to neural tube defects. We found morphogenetic abnormalities in the bulbus cordis (future outflow tract and the right ventricle) of homozygous embryo hearts. Moreover, myocytes in the ventricular trabeculae show hyperplasia with cells filling the ventricles. Together with the observation that the jmj gene is expressed in the neural epithelium of the head neural plate and in myocytes in the bulbus cordis and trabeculae, the results show that the jmj gene plays essential roles in the normal development of the neural plate, morphogenesis of bulbus cordis, and proliferation of trabecular myocytes on a C3H/He background. The recessive mutant mouse jumonji ( jmj), obtained by a gene trap strategy, shows neural tube defects in approximately half of homozygous embryos with a BALB/cA and 129/Ola mixed background, but no neural tube defects with BALB/cA, C57BL/6J, and DBA/2J backgrounds. Here, we show that neural tube and cardiac defects are observed in all embryos with a C3H/HeJ background. In addition, abnormal groove formation and prominent flexure are observed on the neural plate with full penetrance, suggesting that abnormal groove formation leads to neural tube defects. We found morphogenetic abnormalities in the bulbus cordis (future outflow tract and the right ventricle) of homozygous embryo hearts. Moreover, myocytes in the ventricular trabeculae show hyperplasia with cells filling the ventricles. Together with the observation that the jmj gene is expressed in the neural epithelium of the head neural plate and in myocytes in the bulbus cordis and trabeculae, the results show that the jmj gene plays essential roles in the normal development of the neural plate, morphogenesis of bulbus cordis, and proliferation of trabecular myocytes on a C3H/He background. |
| Author | Kojima, Mizuyo Kondo, Shunzo Nakajima, Kuniko Takeuchi, Takashi |
| Author_xml | – sequence: 1 givenname: Takashi surname: Takeuchi fullname: Takeuchi, Takashi email: take@libra.ls.m-kagaku.co.jp – sequence: 2 givenname: Mizuyo surname: Kojima fullname: Kojima, Mizuyo – sequence: 3 givenname: Kuniko surname: Nakajima fullname: Nakajima, Kuniko – sequence: 4 givenname: Shunzo surname: Kondo fullname: Kondo, Shunzo |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/10446263$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1101/gad.9.13.1654 10.1006/geno.1998.5277 10.1182/blood.V93.1.87 10.1002/9780470514559.ch8 10.1073/pnas.90.11.5157 10.1038/378386a0 10.1093/oxfordjournals.jhered.a106131 10.1242/dev.122.6.1799 10.1046/j.1440-169X.1997.t01-1-00001.x 10.1128/MCB.16.3.792 10.1016/S0925-4773(97)00082-8 10.1016/0301-0082(90)90037-H 10.1159/000146455 10.1006/dbio.1996.0046 10.1126/science.7618085 10.1038/378390a0 10.1083/jcb.132.5.849 10.1006/dbio.1995.1245 10.1038/ng0697-154 10.1038/ng0398-271 10.1038/ng0297-207 10.1101/gad.11.11.1357 10.1101/gad.9.24.3067 10.1093/hmg/3.1.153 10.1101/gad.8.24.2964 10.1006/geno.1995.9946 10.1101/gad.9.10.1211 10.1038/ng0398-266 10.1038/378394a0 |
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| Copyright | 1999 Elsevier Science Ireland Ltd |
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| Keywords | Cell proliferation Ventricular trabeculae Heart morphogenesis Neural tube defects Bulbus cordis Gene trap Neural plate Cardiac defects Neurulation Cardiac myocytes Myogenesis jumonji |
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| References | Fattaey, Helin, Dembski, Dyson, Harlow, Vuocolo, Hanobik, Haskell, Oliff, Defeo-Jones, Jones (BIB7) 1993; 8 Gregory, Kortschak, Kalionis, Saint (BIB10) 1996; 16 Letts, Schork, Copp, Bernifield, Frankel (BIB17) 1995; 29 Motoyama, Kitajima, Kojima, Kondo, Takeuchi (BIB22) 1997; 66 O'Brien, Lee, Chien (BIB23) 1993; 90 Baribault, Penner, Iozzo, Wilson-Heiner (BIB1) 1994; 8 Gassmann, Casagranda, Orioli, Simon, Lai, Klein, Lemke (BIB9) 1995; 378 Ross, Navankasattusas, Harvey, Chien (BIB26) 1996; 122 Ishijima, Yasui, Morishima, Shiroishi (BIB13) 1998; 49 Icardo, Fernandez-Teran (BIB12) 1987; 130 Kuisk, Li, Tran, Capetanaki (BIB15) 1996; 174 Peterson, Herskowitz (BIB24) 1992; 68 Morgan (BIB21) 1950; 41 Herrscher, Kaplan, Lelsz, Das, Scheuermann, Tucker (BIB11) 1995; 9 Cserjesi, Brown, Lyons, Olson (BIB6) 1995; 170 Firulli, Mcfadden, Lin, Srivastava, Olson (BIB8) 1998; 18 Riley, Anson-Cartwrught, Cross (BIB25) 1998; 18 Copp, A.J., 1994. Genetic models of mammalian neural tube defects. In: Bock, G., Marsh, J. (Eds.), Neural Tube Defects. Ciba Foundation Symposium, Vol. 181, Wiley, Chichester, pp. 118-143. Lee, Simon, Chen, Bates, Hung, Hauser (BIB16) 1995; 378 Wilkinsons (BIB31) 1992 Kitajima, Kojima, Nakajima, Kondo, Hara, Miyajima, Takeuchi (BIB14) 1999; 93 Li, Miano, Mercer, Olson (BIB18) 1996; 132 Sibilia, Wagner (BIB27) 1995; 269 Meyer, Brichmeier (BIB20) 1995; 378 Bonyadi, Rusholoe, Cousins, Su, Biron, Farrall, Akhurst (BIB3) 1997; 15 Wu, Ellison, Salido, Yen, Mohandas, Shapiro (BIB32) 1994; 3 Lyons, Parsons, Hartley, Li, Andrews, Robb, Harvey (BIB19) 1995; 9 Srivastava, Thomas, Lin, Kirby, Brown, Olson (BIB28) 1997; 16 Takeuchi (BIB30) 1997; 39 Takeuchi, Yamazaki, Katoh-Fukui, Tsuchiya, Kondo, Motoyama, Higashinakagawa (BIB29) 1995; 9 Biben, Harvey (BIB2) 1997; 11 Copp, Brook, Estibeiro, Shum, Cockroft (BIB4) 1990; 35 Motoyama (10.1016/S0925-4773(99)00100-8_BIB22) 1997; 66 Kuisk (10.1016/S0925-4773(99)00100-8_BIB15) 1996; 174 Letts (10.1016/S0925-4773(99)00100-8_BIB17) 1995; 29 Lyons (10.1016/S0925-4773(99)00100-8_BIB19) 1995; 9 Srivastava (10.1016/S0925-4773(99)00100-8_BIB28) 1997; 16 Icardo (10.1016/S0925-4773(99)00100-8_BIB12) 1987; 130 Riley (10.1016/S0925-4773(99)00100-8_BIB25) 1998; 18 Fattaey (10.1016/S0925-4773(99)00100-8_BIB7) 1993; 8 Herrscher (10.1016/S0925-4773(99)00100-8_BIB11) 1995; 9 Lee (10.1016/S0925-4773(99)00100-8_BIB16) 1995; 378 Wilkinsons (10.1016/S0925-4773(99)00100-8_BIB31) 1992 Takeuchi (10.1016/S0925-4773(99)00100-8_BIB30) 1997; 39 Wu (10.1016/S0925-4773(99)00100-8_BIB32) 1994; 3 Gregory (10.1016/S0925-4773(99)00100-8_BIB10) 1996; 16 Meyer (10.1016/S0925-4773(99)00100-8_BIB20) 1995; 378 Takeuchi (10.1016/S0925-4773(99)00100-8_BIB29) 1995; 9 Bonyadi (10.1016/S0925-4773(99)00100-8_BIB3) 1997; 15 O'Brien (10.1016/S0925-4773(99)00100-8_BIB23) 1993; 90 Peterson (10.1016/S0925-4773(99)00100-8_BIB24) 1992; 68 Firulli (10.1016/S0925-4773(99)00100-8_BIB8) 1998; 18 Gassmann (10.1016/S0925-4773(99)00100-8_BIB9) 1995; 378 Li (10.1016/S0925-4773(99)00100-8_BIB18) 1996; 132 Baribault (10.1016/S0925-4773(99)00100-8_BIB1) 1994; 8 Morgan (10.1016/S0925-4773(99)00100-8_BIB21) 1950; 41 Ross (10.1016/S0925-4773(99)00100-8_BIB26) 1996; 122 10.1016/S0925-4773(99)00100-8_BIB5 Cserjesi (10.1016/S0925-4773(99)00100-8_BIB6) 1995; 170 Ishijima (10.1016/S0925-4773(99)00100-8_BIB13) 1998; 49 Sibilia (10.1016/S0925-4773(99)00100-8_BIB27) 1995; 269 Biben (10.1016/S0925-4773(99)00100-8_BIB2) 1997; 11 Copp (10.1016/S0925-4773(99)00100-8_BIB4) 1990; 35 Kitajima (10.1016/S0925-4773(99)00100-8_BIB14) 1999; 93 |
| References_xml | – volume: 15 start-page: 207 year: 1997 end-page: 211 ident: BIB3 article-title: Mapping of a major genetic modifier of embryonic lethality in TGFβ1 knockout mice publication-title: Nat. Genet. contributor: fullname: Akhurst – volume: 170 start-page: 664 year: 1995 end-page: 678 ident: BIB6 article-title: Expression of the novel basic helix-loop-helix gene publication-title: Dev. Biol. contributor: fullname: Olson – volume: 29 start-page: 719 year: 1995 end-page: 724 ident: BIB17 article-title: A curly-tail modifier locus, publication-title: Genomics contributor: fullname: Frankel – volume: 66 start-page: 27 year: 1997 end-page: 37 ident: BIB22 article-title: Organogenesis of the liver, thymus and spleen is affected in publication-title: Mech Dev. contributor: fullname: Takeuchi – volume: 9 start-page: 1654 year: 1995 end-page: 1666 ident: BIB19 article-title: Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene publication-title: Genes Dev. contributor: fullname: Harvey – volume: 122 start-page: 1799 year: 1996 end-page: 1809 ident: BIB26 article-title: An HF-1a/HF-1b/MEF-2 combinational element confers cardiac ventricular specificity and establishes an anterior-posterior gradient of expression publication-title: Development contributor: fullname: Chien – volume: 49 start-page: 341 year: 1998 end-page: 350 ident: BIB13 article-title: Dominant lethality of the mouse skeletal mutation tail-short publication-title: Genomics contributor: fullname: Shiroishi – volume: 41 start-page: 208 year: 1950 end-page: 215 ident: BIB21 article-title: A new Tail-short mutation in the mouse publication-title: J. Hered. contributor: fullname: Morgan – volume: 378 start-page: 390 year: 1995 end-page: 394 ident: BIB9 article-title: Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor publication-title: Nature contributor: fullname: Lemke – volume: 130 start-page: 264 year: 1987 end-page: 274 ident: BIB12 article-title: Morphologic study of ventricular trabeculation in the embryonic chick heart publication-title: Acta Anat. contributor: fullname: Fernandez-Teran – start-page: 75 year: 1992 end-page: 84 ident: BIB31 article-title: Whole mount in situ hybridization of vertebrate embryos publication-title: In Situ Hybridization: A Practical Approach contributor: fullname: Wilkinsons – volume: 90 start-page: 5157 year: 1993 end-page: 5161 ident: BIB23 article-title: Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Chien – volume: 9 start-page: 1211 year: 1995 end-page: 1222 ident: BIB29 article-title: Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation publication-title: Genes Dev. contributor: fullname: Higashinakagawa – volume: 8 start-page: 2964 year: 1994 end-page: 2973 ident: BIB1 article-title: Colorectal hyperplasia and inflammation in keratin 8-deficient FNB/N mice publication-title: Genes Dev. contributor: fullname: Wilson-Heiner – volume: 378 start-page: 386 year: 1995 end-page: 390 ident: BIB20 article-title: Multiple essential functions of neuregulin in development publication-title: Nature contributor: fullname: Brichmeier – volume: 269 start-page: 234 year: 1995 end-page: 238 ident: BIB27 article-title: Strain-dependent epithelial defects in mice lacking the EGF receptor publication-title: Science contributor: fullname: Wagner – volume: 11 start-page: 1357 year: 1997 end-page: 1369 ident: BIB2 article-title: Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene publication-title: Genes Dev. contributor: fullname: Harvey – volume: 16 start-page: 154 year: 1997 end-page: 160 ident: BIB28 article-title: Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND publication-title: Nat. Genet. contributor: fullname: Olson – volume: 39 start-page: 127 year: 1997 end-page: 134 ident: BIB30 article-title: A gene trap approach to identify genes that control development publication-title: Dev. Growth Differ. contributor: fullname: Takeuchi – volume: 8 start-page: 3149 year: 1993 end-page: 3156 ident: BIB7 article-title: Characterization of the retinoblastoma binding proteins RBP1 and RBP2 publication-title: Oncogene contributor: fullname: Jones – volume: 16 start-page: 792 year: 1996 end-page: 799 ident: BIB10 article-title: Characterization of the publication-title: Mol. Cell. Biol. contributor: fullname: Saint – volume: 174 start-page: 1 year: 1996 end-page: 13 ident: BIB15 article-title: A single MEF2 site governs desmin transcription in both heart and skeletal muscle during mouse embryogenesis publication-title: Dev. Biol. contributor: fullname: Capetanaki – volume: 18 start-page: 271 year: 1998 end-page: 275 ident: BIB25 article-title: The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis publication-title: Nat. Genet. contributor: fullname: Cross – volume: 68 start-page: 573 year: 1992 end-page: 583 ident: BIB24 article-title: Characterization of the yeast publication-title: contributor: fullname: Herskowitz – volume: 378 start-page: 394 year: 1995 end-page: 398 ident: BIB16 article-title: Requirement for neuregulin receptor erbB2 in neural and cardiac development publication-title: Nature contributor: fullname: Hauser – volume: 93 start-page: 87 year: 1999 end-page: 95 ident: BIB14 article-title: Definitive but not primitive hematopoiesis is impaired in publication-title: Blood contributor: fullname: Takeuchi – volume: 3 start-page: 153 year: 1994 end-page: 160 ident: BIB32 article-title: Isolation and characterization of publication-title: Hum. Mol. Genet. contributor: fullname: Shapiro – volume: 18 start-page: 266 year: 1998 end-page: 270 ident: BIB8 article-title: Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand 1 publication-title: Nat. Genet. contributor: fullname: Olson – volume: 9 start-page: 3067 year: 1995 end-page: 3082 ident: BIB11 article-title: The immunoglobulin heavy-chain matrix- associating regions are bound by Bright: a B cell-specific publication-title: Genes Dev. contributor: fullname: Tucker – volume: 132 start-page: 849 year: 1996 end-page: 859 ident: BIB18 article-title: Expression of the publication-title: J. Cell. Biol. contributor: fullname: Olson – volume: 35 start-page: 363 year: 1990 end-page: 403 ident: BIB4 article-title: The embryonic development of mammalian neural tube defects publication-title: Prog. Neurobiol. contributor: fullname: Cockroft – volume: 9 start-page: 1654 year: 1995 ident: 10.1016/S0925-4773(99)00100-8_BIB19 article-title: Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5 publication-title: Genes Dev. doi: 10.1101/gad.9.13.1654 contributor: fullname: Lyons – volume: 49 start-page: 341 year: 1998 ident: 10.1016/S0925-4773(99)00100-8_BIB13 article-title: Dominant lethality of the mouse skeletal mutation tail-short (Ts) is determined by the Ts allele from mating parents publication-title: Genomics doi: 10.1006/geno.1998.5277 contributor: fullname: Ishijima – volume: 93 start-page: 87 year: 1999 ident: 10.1016/S0925-4773(99)00100-8_BIB14 article-title: Definitive but not primitive hematopoiesis is impaired in jumonji mutant mice publication-title: Blood doi: 10.1182/blood.V93.1.87 contributor: fullname: Kitajima – ident: 10.1016/S0925-4773(99)00100-8_BIB5 doi: 10.1002/9780470514559.ch8 – volume: 90 start-page: 5157 year: 1993 ident: 10.1016/S0925-4773(99)00100-8_BIB23 article-title: Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.90.11.5157 contributor: fullname: O'Brien – volume: 378 start-page: 386 year: 1995 ident: 10.1016/S0925-4773(99)00100-8_BIB20 article-title: Multiple essential functions of neuregulin in development publication-title: Nature doi: 10.1038/378386a0 contributor: fullname: Meyer – volume: 41 start-page: 208 year: 1950 ident: 10.1016/S0925-4773(99)00100-8_BIB21 article-title: A new Tail-short mutation in the mouse publication-title: J. Hered. doi: 10.1093/oxfordjournals.jhered.a106131 contributor: fullname: Morgan – volume: 122 start-page: 1799 year: 1996 ident: 10.1016/S0925-4773(99)00100-8_BIB26 article-title: An HF-1a/HF-1b/MEF-2 combinational element confers cardiac ventricular specificity and establishes an anterior-posterior gradient of expression publication-title: Development doi: 10.1242/dev.122.6.1799 contributor: fullname: Ross – volume: 39 start-page: 127 year: 1997 ident: 10.1016/S0925-4773(99)00100-8_BIB30 article-title: A gene trap approach to identify genes that control development publication-title: Dev. Growth Differ. doi: 10.1046/j.1440-169X.1997.t01-1-00001.x contributor: fullname: Takeuchi – volume: 16 start-page: 792 year: 1996 ident: 10.1016/S0925-4773(99)00100-8_BIB10 article-title: Characterization of the dead ringer gene identifies a novel, highly conserved family of sequence-specific DNA-binding proteins publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.16.3.792 contributor: fullname: Gregory – volume: 66 start-page: 27 year: 1997 ident: 10.1016/S0925-4773(99)00100-8_BIB22 article-title: Organogenesis of the liver, thymus and spleen is affected in jumonji mutant mice publication-title: Mech Dev. doi: 10.1016/S0925-4773(97)00082-8 contributor: fullname: Motoyama – volume: 8 start-page: 3149 year: 1993 ident: 10.1016/S0925-4773(99)00100-8_BIB7 article-title: Characterization of the retinoblastoma binding proteins RBP1 and RBP2 publication-title: Oncogene contributor: fullname: Fattaey – volume: 35 start-page: 363 year: 1990 ident: 10.1016/S0925-4773(99)00100-8_BIB4 article-title: The embryonic development of mammalian neural tube defects publication-title: Prog. Neurobiol. doi: 10.1016/0301-0082(90)90037-H contributor: fullname: Copp – volume: 130 start-page: 264 year: 1987 ident: 10.1016/S0925-4773(99)00100-8_BIB12 article-title: Morphologic study of ventricular trabeculation in the embryonic chick heart publication-title: Acta Anat. doi: 10.1159/000146455 contributor: fullname: Icardo – volume: 174 start-page: 1 year: 1996 ident: 10.1016/S0925-4773(99)00100-8_BIB15 article-title: A single MEF2 site governs desmin transcription in both heart and skeletal muscle during mouse embryogenesis publication-title: Dev. Biol. doi: 10.1006/dbio.1996.0046 contributor: fullname: Kuisk – volume: 269 start-page: 234 year: 1995 ident: 10.1016/S0925-4773(99)00100-8_BIB27 article-title: Strain-dependent epithelial defects in mice lacking the EGF receptor publication-title: Science doi: 10.1126/science.7618085 contributor: fullname: Sibilia – volume: 378 start-page: 390 year: 1995 ident: 10.1016/S0925-4773(99)00100-8_BIB9 article-title: Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor publication-title: Nature doi: 10.1038/378390a0 contributor: fullname: Gassmann – volume: 132 start-page: 849 year: 1996 ident: 10.1016/S0925-4773(99)00100-8_BIB18 article-title: Expression of the SM22α promoter in transgenic mice provides evidence for distinct transcriptional regulatory programs in vascular and visceral smooth muscle cells publication-title: J. Cell. Biol. doi: 10.1083/jcb.132.5.849 contributor: fullname: Li – volume: 170 start-page: 664 year: 1995 ident: 10.1016/S0925-4773(99)00100-8_BIB6 article-title: Expression of the novel basic helix-loop-helix gene eHand in neural crest derivatives and extraembryonic membranes during mouse development publication-title: Dev. Biol. doi: 10.1006/dbio.1995.1245 contributor: fullname: Cserjesi – volume: 16 start-page: 154 year: 1997 ident: 10.1016/S0925-4773(99)00100-8_BIB28 article-title: Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND publication-title: Nat. Genet. doi: 10.1038/ng0697-154 contributor: fullname: Srivastava – volume: 18 start-page: 271 year: 1998 ident: 10.1016/S0925-4773(99)00100-8_BIB25 article-title: The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis publication-title: Nat. Genet. doi: 10.1038/ng0398-271 contributor: fullname: Riley – volume: 15 start-page: 207 year: 1997 ident: 10.1016/S0925-4773(99)00100-8_BIB3 article-title: Mapping of a major genetic modifier of embryonic lethality in TGFβ1 knockout mice publication-title: Nat. Genet. doi: 10.1038/ng0297-207 contributor: fullname: Bonyadi – volume: 11 start-page: 1357 year: 1997 ident: 10.1016/S0925-4773(99)00100-8_BIB2 article-title: Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development publication-title: Genes Dev. doi: 10.1101/gad.11.11.1357 contributor: fullname: Biben – volume: 9 start-page: 3067 year: 1995 ident: 10.1016/S0925-4773(99)00100-8_BIB11 article-title: The immunoglobulin heavy-chain matrix- associating regions are bound by Bright: a B cell-specific trans-activator that describes a new DNA-binding protein family publication-title: Genes Dev. doi: 10.1101/gad.9.24.3067 contributor: fullname: Herrscher – volume: 68 start-page: 573 year: 1992 ident: 10.1016/S0925-4773(99)00100-8_BIB24 article-title: Characterization of the yeast SWI1 publication-title: SWI2, and SWI3 genes, which encode a global activator of transcription. Cell contributor: fullname: Peterson – volume: 3 start-page: 153 year: 1994 ident: 10.1016/S0925-4773(99)00100-8_BIB32 article-title: Isolation and characterization of XE169, a novel human gene that escapes X-inactivation publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/3.1.153 contributor: fullname: Wu – volume: 8 start-page: 2964 year: 1994 ident: 10.1016/S0925-4773(99)00100-8_BIB1 article-title: Colorectal hyperplasia and inflammation in keratin 8-deficient FNB/N mice publication-title: Genes Dev. doi: 10.1101/gad.8.24.2964 contributor: fullname: Baribault – start-page: 75 year: 1992 ident: 10.1016/S0925-4773(99)00100-8_BIB31 article-title: Whole mount in situ hybridization of vertebrate embryos contributor: fullname: Wilkinsons – volume: 29 start-page: 719 year: 1995 ident: 10.1016/S0925-4773(99)00100-8_BIB17 article-title: A curly-tail modifier locus, mct1, on mouse chromosome 17 publication-title: Genomics doi: 10.1006/geno.1995.9946 contributor: fullname: Letts – volume: 9 start-page: 1211 year: 1995 ident: 10.1016/S0925-4773(99)00100-8_BIB29 article-title: Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation publication-title: Genes Dev. doi: 10.1101/gad.9.10.1211 contributor: fullname: Takeuchi – volume: 18 start-page: 266 year: 1998 ident: 10.1016/S0925-4773(99)00100-8_BIB8 article-title: Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand 1 publication-title: Nat. Genet. doi: 10.1038/ng0398-266 contributor: fullname: Firulli – volume: 378 start-page: 394 year: 1995 ident: 10.1016/S0925-4773(99)00100-8_BIB16 article-title: Requirement for neuregulin receptor erbB2 in neural and cardiac development publication-title: Nature doi: 10.1038/378394a0 contributor: fullname: Lee |
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| Snippet | The recessive mutant mouse
jumonji (
jmj), obtained by a gene trap strategy, shows neural tube defects in approximately half of homozygous embryos with a... The recessive mutant mouse jumonji (jmj), obtained by a gene trap strategy, shows neural tube defects in approximately half of homozygous embryos with a... |
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| SubjectTerms | Animals Bulbus cordis Cardiac defects Cardiac myocytes Cell proliferation Disease Models, Animal Gene Expression Regulation, Developmental Gene trap Heart - embryology Heart Defects, Congenital - genetics Heart Defects, Congenital - pathology Heart Defects, Congenital - veterinary Heart morphogenesis Heart Ventricles - metabolism Homozygote jumonji Mice Mice, Inbred BALB C Mice, Inbred C3H - genetics Mice, Mutant Strains Myocardium - cytology Myocardium - pathology Myogenesis Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neural plate Neural tube defects Neural Tube Defects - genetics Neural Tube Defects - veterinary Neurulation Phenotype Polycomb Repressive Complex 2 Rodent Diseases - genetics Ventricular trabeculae |
| Title | jumonji gene is essential for the neurulation and cardiac development of mouse embryos with a C3H/He background |
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