Case report: Successful autologous hematopoietic stem cell transplantation in a patient with GAD antibody-spectrum disorder with rapidly progressive dementia
The prevalence of neurological syndromes associated with antibodies to glutamic acid decarboxylase is increasing. While cognitive impairment is a common feature of this condition, it seldom emerges as the primary symptom. In this study, we discuss a case of refractory dementia associated with the gl...
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| Published in: | Frontiers in neurology Vol. 14 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
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19-10-2023
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| Abstract | The prevalence of neurological syndromes associated with antibodies to glutamic acid decarboxylase is increasing. While cognitive impairment is a common feature of this condition, it seldom emerges as the primary symptom. In this study, we discuss a case of refractory dementia associated with the glutamic acid decarboxylase spectrum disorder. Interestingly, this case showed a favorable outcome following autologous hematopoietic stem cell transplantation. We also provide an in-depth review of the current literature on the use of this therapeutic approach for the treatment of this disease. |
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| AbstractList | The prevalence of neurological syndromes associated with antibodies to glutamic acid decarboxylase is increasing. While cognitive impairment is a common feature of this condition, it seldom emerges as the primary symptom. In this study, we discuss a case of refractory dementia associated with the glutamic acid decarboxylase spectrum disorder. Interestingly, this case showed a favorable outcome following autologous hematopoietic stem cell transplantation. We also provide an in-depth review of the current literature on the use of this therapeutic approach for the treatment of this disease. |
| Author | Kowacs, Dora Pedroso Teive, Hélio Afonso Ghizoni Kowacs, Pedro André Nabhan, Samir Kanaan Disserol, Caio César Diniz |
| AuthorAffiliation | 3 Blood and Marrow Transplantation Program, Hospital de Clínicas, Federal University of Paraná , Curitiba , Brazil 1 Department of Neurology, Instituto de Neurologia de Curitiba , Curitiba , Brazil 2 Department of Neurology, Complexo do Hospital de Clínicas da Universidade Federal do Paraná , Curitiba , Brazil |
| AuthorAffiliation_xml | – name: 2 Department of Neurology, Complexo do Hospital de Clínicas da Universidade Federal do Paraná , Curitiba , Brazil – name: 3 Blood and Marrow Transplantation Program, Hospital de Clínicas, Federal University of Paraná , Curitiba , Brazil – name: 1 Department of Neurology, Instituto de Neurologia de Curitiba , Curitiba , Brazil |
| Author_xml | – sequence: 1 givenname: Caio César Diniz surname: Disserol fullname: Disserol, Caio César Diniz – sequence: 2 givenname: Dora Pedroso surname: Kowacs fullname: Kowacs, Dora Pedroso – sequence: 3 givenname: Samir Kanaan surname: Nabhan fullname: Nabhan, Samir Kanaan – sequence: 4 givenname: Hélio Afonso Ghizoni surname: Teive fullname: Teive, Hélio Afonso Ghizoni – sequence: 5 givenname: Pedro André surname: Kowacs fullname: Kowacs, Pedro André |
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| Cites_doi | 10.1007/s13760-022-01937-w 10.1056/NEJMra1708712 10.3389/fneur.2021.641024 10.1016/j.jns.2014.05.032 10.1038/s41409-021-01277-y 10.1177/17562864211003486 10.1038/s41582-022-00659-0 10.1001/jamaneurol.2014.1297 10.1186/1471-2377-11-156 10.1016/j.psc.2022.07.011 10.1016/j.jns.2017.08.3720 10.1111/nyas.12553 10.3747/co.26.5033 10.1016/j.braindev.2018.10.006 10.1007/s13311-022-01188-w 10.1093/brain/awz311 10.1212/WNL.0000000000011338 10.1016/j.arr.2021.101478 10.1016/j.jneuroim.2022.577915 10.1177/1756286421998906 10.1016/j.jalz.2011.03.005 10.1016/j.jcyt.2021.12.006 10.1007/s00415-020-10054-8 10.1007/s13760-021-01766-3 10.1002/alz.067009 10.1001/archneurol.2012.234 |
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| Copyright | Copyright © 2023 Disserol, Kowacs, Nabhan, Teive and Kowacs. 2023 Disserol, Kowacs, Nabhan, Teive and Kowacs |
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| Notes | These authors have contributed equally to this work Edited by: Hans-Peter Hartung, Heinrich Heine University, Germany Reviewed by: Petia Dimova, University Hospital St. Ivan Rilski, Bulgaria; Erdem Tüzün, Istanbul University, Türkiye; José Fidel Baizabal-Carvallo, University of Guanajuato, Mexico |
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| Title | Case report: Successful autologous hematopoietic stem cell transplantation in a patient with GAD antibody-spectrum disorder with rapidly progressive dementia |
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