Case report: Successful autologous hematopoietic stem cell transplantation in a patient with GAD antibody-spectrum disorder with rapidly progressive dementia

The prevalence of neurological syndromes associated with antibodies to glutamic acid decarboxylase is increasing. While cognitive impairment is a common feature of this condition, it seldom emerges as the primary symptom. In this study, we discuss a case of refractory dementia associated with the gl...

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Bibliographic Details
Published in:	Frontiers in neurology Vol. 14
Main Authors:	Disserol, Caio César Diniz, Kowacs, Dora Pedroso, Nabhan, Samir Kanaan, Teive, Hélio Afonso Ghizoni, Kowacs, Pedro André
Format:	Journal Article
Language:	English
Published:	Frontiers Media S.A 19-10-2023
Subjects:	autoimmune diseases of the nervous system dementia encephalitis glutamic acid decarboxylase neurocognitive disorders Neurology
Online Access:	Get full text
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Summary:	The prevalence of neurological syndromes associated with antibodies to glutamic acid decarboxylase is increasing. While cognitive impairment is a common feature of this condition, it seldom emerges as the primary symptom. In this study, we discuss a case of refractory dementia associated with the glutamic acid decarboxylase spectrum disorder. Interestingly, this case showed a favorable outcome following autologous hematopoietic stem cell transplantation. We also provide an in-depth review of the current literature on the use of this therapeutic approach for the treatment of this disease.
Bibliography:	These authors have contributed equally to this work Edited by: Hans-Peter Hartung, Heinrich Heine University, Germany Reviewed by: Petia Dimova, University Hospital St. Ivan Rilski, Bulgaria; Erdem Tüzün, Istanbul University, Türkiye; José Fidel Baizabal-Carvallo, University of Guanajuato, Mexico
ISSN:	1664-2295 1664-2295
DOI:	10.3389/fneur.2023.1254981