Glucose-6-Phosphate Dehydrogenase Deficiency Diagnosed in an Adolescent with Type 1 Diabetes Mellitus and Hemoglobin A1c Discordant with Blood Glucose Measurements

Disorders of hemolysis reduce the exposure time of hemoglobin to glucose, resulting in a falsely low hemoglobin A1c level. This case report describes the unexpected diagnosis of glucose-6-phosphate dehydrogenase deficiency made during evaluation of discordant HbA1c and blood glucose measurements.

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Bibliographic Details
Published in:	The Journal of pediatrics Vol. 158; no. 5; pp. 849 - 851
Main Authors:	Danzig, Jennifer A., MD, Moser, Joanne T., MSN, CRNP, Belfield, Pattianne, MSN, CRNP, Alter, Craig A., MD
Format:	Journal Article
Language:	English
Published:	United States Mosby, Inc 01-05-2011
Subjects:	Adolescent Blood Glucose - analysis Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - complications Diagnosis, Differential Glucosephosphate Dehydrogenase Deficiency - blood Glucosephosphate Dehydrogenase Deficiency - complications Glucosephosphate Dehydrogenase Deficiency - diagnosis Glycated Hemoglobin A - metabolism Humans Male Pediatrics NADPH T1DM G6PD RBC Hemoglobin A1c Nicotinamide adenine dinucleotide phosphate Red blood cell Glucose-6-phosphate dehydrogenase HbA1c Type 1 diabetes mellitus
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Description
Summary:	Disorders of hemolysis reduce the exposure time of hemoglobin to glucose, resulting in a falsely low hemoglobin A1c level. This case report describes the unexpected diagnosis of glucose-6-phosphate dehydrogenase deficiency made during evaluation of discordant HbA1c and blood glucose measurements.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0022-3476 1097-6833
DOI:	10.1016/j.jpeds.2010.12.012