Preimplantation genetic diagnosis (PGD), a collaborative activity of clinical genetic departments and IVF centres

• Published in: Prenatal diagnosis Vol. 21; no. 12; pp. 1086 - 1092
• Main Authors: Geraedts, Joep P. M., Harper, Joyce, Braude, Peter, Sermon, Karen, Veiga, Anna, Gianaroli, Luca, Agan, Noelle, Munné, Santiago, Gitlin, Sue, Blenow, Elisabeth, de Boer, Kylie, Hussey, Nicole, Kanavakis, Emmanuel, Lee, Soo-Huan, Viville, Stéphane, Krey, Lewis, Ray, Pierre, Emiliani, Serena, Hsien Liu, Yung, Vermeulen, Stefan
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01-12-2001; Wiley
• Subjects: Aneuploidy; Biological and medical sciences; Birth control; Chromosome Aberrations; Female; Fertilization in Vitro; FISH; Forms and Records Control; Genetic Counseling; Genetics; Genetics, Medical; Gynecology. Andrology. Obstetrics; Health Care Costs; Hospital Departments; Humans; in vitro fertilisation (IVF); Informed Consent - legislation & jurisprudence; Interinstitutional Relations; intracytoplasmatic sperm injection (ICSI); Life Sciences; Medical sciences; PCR; Pregnancy; Preimplantation Diagnosis - economics; preimplantation genetic diagnosis (PGD); Sperm Injections, Intracytoplasmic; Sterility. Assisted procreation; Surveys and Questionnaires; Availability; In vitro fertilization embryo transfer; Human; Preimplantation diagnosis; Embryo; Genetic counseling; Questionnaire; Intracytoplasmic sperm injection; Assisted procreation; Consortium; Genetics; Bibliographic review
• ISSN: 0197-3851; 1097-0223
• DOI: 10.1002/pd.249

An Erratum has been published for this article in Prenatal Diagnosis 22 (5) 2002, 451.
Preimplantation genetic diagnosis (PGD) requires the combined efforts of geneticists and workers in the field of reproductive medicine. This was studied on the basis of a questionnaire, sent to 35 members of the PGD Consortium of the European Society of Human Reproduction and Embryology (ESHRE). A reply was obtained from 20 centres. They represent the majority of activities in the field of PGD in the world.
It is obvious that many of the activities (in vitro fertilisation, embryo culture and biopsy) take place in IVF units while others (counselling and diagnosis) are the responsibility of genetic diagnostic centres. The distances between both units vary considerably.
In all but one centre sex determination is offered. Aneuploidy screening is offered in 13 out of 20 centres. PGD of translocations and other structural chromosome abnormalities is offered in all but one centre. The number of monogenic diseases offered varies considerably.
In comparison to prenatal diagnosis PGD is more expensive. The majority of these costs are due to the IVF or ICSI procedure. The charges for PGD vary between about € 600 and € 4000. In 16 out of 20 centres the parents to be must sign an informed consent form. Copyright © 2001 John Wiley & Sons, Ltd.