Pyocyanin and 1-hydroxyphenazine produced by Pseudomonas aeruginosa inhibit the beating of human respiratory cilia in vitro

Pseudomonas aeruginosa culture filtrates varied in their ability to slow human ciliary beat frequency (7-71%). This activity did not correlate with known virulence factors. However, a close correlation (r = 0.97) existed between ciliary slowing and pigment content. In a prolonged culture, the increa...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 79; no. 1; pp. 221 - 229
Main Authors:	WILSON, R, PITT, T, TAYLOR, G, WATSON, D, MACDERMOT, J, SYKES, D, ROBERTS, D, COLE, P
Format:	Journal Article
Language:	English
Published:	Ann Arbor, MI American Society for Clinical Investigation 1987
Subjects:	Alginates - pharmacology Applied sciences Biological and medical sciences Cilia - drug effects Epithelium - drug effects Exact sciences and technology Humans In Vitro Techniques Lipopolysaccharides - pharmacology Medical sciences Other techniques and industries Pharmacology. Drug treatments Phenazines - isolation & purification Phenazines - pharmacology Pigments, Biological - analysis Pseudomonas aeruginosa Pseudomonas aeruginosa - pathogenicity Pyocyanine - isolation & purification Pyocyanine - pharmacology Respiratory system Respiratory System - drug effects Ciliated cell Motility Inhibition Respiratory epithelium Biological activity
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