Cardiomyocyte Krüppel-Like Factor 5 Promotes De Novo Ceramide Biosynthesis and Contributes to Eccentric Remodeling in Ischemic Cardiomyopathy

We previously showed that cardiomyocyte Krϋppel-like factor (KLF) 5 regulates cardiac fatty acid oxidation. As heart failure has been associated with altered fatty acid oxidation, we investigated the role of cardiomyocyte KLF5 in lipid metabolism and pathophysiology of ischemic heart failure. Using...

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Bibliographic Details

Published in:	Circulation (New York, N.Y.) Vol. 143; no. 11; pp. 1139 - 1156
Main Authors:	Hoffman, Matthew, Palioura, Dimitra, Kyriazis, Ioannis D., Cimini, Maria, Badolia, Rachit, Rajan, Sudarsan, Gao, Erhe, Nikolaidis, Nikolas, Schulze, P. Christian, Goldberg, Ira J., Kishore, Raj, Yang, Vincent W., Bannister, Thomas D., Bialkowska, Agnieszka B., Selzman, Craig H., Drakos, Stavros G., Drosatos, Konstantinos
Format:	Journal Article
Language:	English
Published:	United States Lippincott Williams & Wilkins 16-03-2021
Subjects:	Animals Cardiomyopathies - physiopathology Ceramides - metabolism Disease Models, Animal Humans Kruppel-Like Transcription Factors - metabolism Male Mice Myocytes, Cardiac - metabolism Ventricular Remodeling - physiology heart failure myocardial ischemia cardiomyopathies ceramides
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