Regulation of cell cycle-dependent gene expression in yeast

• Published in: The Journal of biological chemistry Vol. 265; no. 24; pp. 14057 - 14060
• Main Authors: ANDREWS, B. J, HERSKOWITZ, I
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Biochemistry and Molecular Biology 25-08-1990
• Subjects: Amino Acid Sequence; Base Sequence; Biological and medical sciences; Cell Cycle; Fundamental and applied biological sciences. Psychology; Fungal Proteins - genetics; Gene expression; Gene Expression Regulation, Fungal; Genes, Fungal; Molecular and cellular biology; Molecular genetics; Molecular Sequence Data; Promoter Regions, Genetic; Saccharomyces cerevisiae - cytology; Saccharomyces cerevisiae - genetics; Fungi; Regulation(control); Yeast; Gene; Cell cycle; Ascomycetes; Review; Gene expression; Mechanism of action; Saccharomyces cerevisiae; Thallophyta
• ISSN: 0021-9258; 1083-351X
• DOI: 10.1016/S0021-9258(18)77265-7

In this paper, we review the genes from budding yeast whose expression is restricted to defined periods of the cell cycle. We discuss the mechanism by which genes are rendered sensitive to cues in the cell cycle through a consideration of the upstream regulatory sequences of cell cycle-regulated genes and of the proteins involved in recognizing these sequences. We emphasize the single example, the HO gene, for which the regulatory circuit leading to cell cycle-specific gene expression has been defined both genetically and biochemically.