α-Cyclodextrin-based poly(pseudo)rotaxane for antifungal drug delivery to the vaginal mucosa

This work aimed to evaluate poly(pseudo)rotaxanes (PPRs) potential for vaginal antifungal delivery. For this, PPRs containing terbinafine (TB) 2 % were obtained using two small surfactants, Kolliphor® RH40 and Gelucire® 48/16, and different α-cyclodextrin (α-CD) concentrations (5 and 10 %). PPRs wer...

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Bibliographic Details
Published in:	Carbohydrate polymers Vol. 302; p. 120420
Main Authors:	Costa, Rayssa H.F., Krawczyk-Santos, Anna Paula, Martins Andrade, Jayanaraian F., Barbalho, Geisa N., Almeida, Rosane M., Nóbrega, Yanna K.M., Cunha-Filho, Marcilio, Gelfuso, Guilherme M., Taveira, Stephânia F., Gratieri, Tais
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 15-02-2023
Subjects:	Alpha-cyclodextrin alpha-Cyclodextrins Animals Antifungal Agents - chemistry Candida albicans Candidiasis Female Mixed micelles Mucous Membrane Poly(pseudo)rotaxanes Rotaxanes - chemistry Swine Terbinafine Vagina Vaginal drug delivery Mixed micelles Poly(pseudo)rotaxanes Candidiasis Vaginal drug delivery Terbinafine Alpha-cyclodextrin
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