Role of muscarinic and nicotinic cholinergic receptors in an experimental model of epilepsy-induced analgesia

The blockade of GABA-mediated Cl − influx with pentylenetetrazol (PTZ) was used in the present work to induce seizures in animals. The neurotransmission in the postictal period has been the focus of many studies, and there is evidence suggesting antinociceptive mechanisms following tonic–clonic seiz...

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Published in:	Pharmacology, biochemistry and behavior Vol. 79; no. 2; pp. 367 - 376
Main Authors:	de Freitas, Renato Leonardo, de Oliveira, Rithiele Cristina, de Carvalho, Andressa Daiane, Felippotti, Tatiana Tocchini, Bassi, Gabriel Shimizu, Elias-Filho, Daoud Hibrahim, Coimbra, Norberto Cysne
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-10-2004 Elsevier Science
Subjects:	Acetylcholine Animals Atropine - pharmacology Biological and medical sciences Chlorides - metabolism Convulsants - toxicity Epilepsy Epilepsy - chemically induced Epilepsy - physiopathology GABA A receptor GABA Antagonists - toxicity Male Mecamylamine - pharmacology Medical sciences Muscarinic Antagonists - pharmacology Muscarinic receptor Neuropharmacology Nicotinic Antagonists - pharmacology Nicotinic receptor Nociceptors - physiopathology Pain Pain Measurement Pentylenetetrazol Pentylenetetrazole - toxicity Pharmacology. Drug treatments Postictal analgesia Rats Rats, Wistar Receptors, GABA-A - physiology Receptors, Muscarinic - physiology Receptors, Nicotinic - physiology Pain GABA A receptor Pentylenetetrazol Epilepsy Acetylcholine Muscarinic receptor Nicotinic receptor Postictal analgesia Nervous system diseases Pentetrazol CNS stimulant Psychotropic Cerebral disorder Respiratory analeptic Analgesia Cholinergic receptor Central nervous system disease Neurotransmitter Models GABAA receptor Gabaergic receptor A
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