Investigating the electrochemical profile of methamphetamine to enable fast on-site detection in forensic analysis

• Published in: Talanta (Oxford) Vol. 255; p. 124208
• Main Authors: Dragan, Ana-Maria, Parrilla, Marc, Sleegers, Nick, Slosse, Amorn, Van Durme, Filip, van Nuijs, Alexander, Oprean, Radu, Cristea, Cecilia, De Wael, Karolien
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-04-2023
• Subjects: Central Nervous System Stimulants; Chromatography, Liquid; Electrochemical profile; Electrodes; Forensic Medicine; FTIR spectrometer; Methamphetamine; Methamphetamine - analysis; On-site forensic analysis; Psychotropic Drugs - analysis; Raman spectrometer; Redox pathway; Raman spectrometer; Electrochemical profile; On-site forensic analysis; FTIR spectrometer; Redox pathway; Methamphetamine
• ISSN: 0039-9140; 1873-3573
• DOI: 10.1016/j.talanta.2022.124208

Methamphetamine (MA) is a synthetic psychoactive drug which is consumed both licitly and illicitly. In some countries it is prescribed for attention-deficit and hyperactivity disorder, and short-term treatment of obesity. More often though, it is abused for its psychostimulant properties. Unfortunately, the spread and abuse of this synthetic drug have increased globally, being reported as the most widely consumed synthetic psychoactive drug in the world in 2019. Attempting to overcome the shortcomings of the currently used on-site methods for MA detection in suspected cargos, the present study explores the potential of electrochemical identification of MA by means of square wave voltammetry on disposable graphite screen-printed electrodes. Hence, the analytical characterization of the method was evaluated under optimal conditions exhibiting a linear range between 50 μM and 2.5 mM MA, a LOD of 16.7 μM, a LOQ of 50.0 μM and a sensitivity of 5.3 μA mM−1. Interestingly, two zones in the potential window were identified for the detection of MA, depending on its concentration in solution. Furthermore, the oxidative pathway of MA was elucidated employing liquid chromatography – mass spectrometry to understand the change in the electrochemical profile. Thereafter, the selectivity of the method towards MA in mixtures with other drugs of abuse as well as common adulterants/cutting agents was evaluated. Finally, the described method was employed for the analysis of MA in confiscated samples and compared with forensic methods, displaying its potential as a fast and easy-to-use method for on-site analysis.
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•Investigation of the electrochemical behavior of MA over a wide concentration range.•Selective detection of MA in mixtures with other illicit drugs and adulterants.•Voltammetric sensing of MA in confiscated samples using screen-printed electrodes.•Fast and portable device with high sensitivity, specificity and acurracy.