Galactosilated dopamine increases attention without reducing activity in C57BL/6 mice

• Published in: Behavioural brain research Vol. 187; no. 2; pp. 449 - 454
• Main Authors: Ruocco, L.A., Viggiano, D., Pignatelli, M., Iannaccone, T., Rimoli, M.G., Melisi, D., Curcio, A., De Lucia, S., Carboni, E., Carnevale, U.A. Gironi, de Caprariis, P., Sadile, A.G.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 05-03-2008; Elsevier Science
• Subjects: ADHD; Analysis of Variance; Animals; Attention - physiology; Attention Deficit Disorder with Hyperactivity - drug therapy; Attention Deficit Disorder with Hyperactivity - metabolism; Behavioral psychophysiology; Biological and medical sciences; Disease Models, Animal; Dopamine - administration & dosage; Dopamine - metabolism; Dose-Response Relationship, Drug; Drug Carriers; Female; Fundamental and applied biological sciences. Psychology; Galactose - administration & dosage; Galactose - analogs & derivatives; Galactose - metabolism; Genetic models; Male; Maze Learning - physiology; Mice; Mice, Inbred C57BL; Motor Activity - physiology; Prodrug; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Species Specificity; Statistics, Nonparametric; ADHD; Genetic models; Prodrug; Dopamine; Hyperactivity; Rodentia; Attention; Catecholamine; Vertebrata; Mammalia; Attentional disorder; Mouse; Animal; Neurotransmitter; Genetics; Models; Attention disorder with hyperactivity
• ISSN: 0166-4328; 1872-7549
• DOI: 10.1016/j.bbr.2007.10.007

Different strategies can be used to carry dopamine into the brain such as
l-Dopa precursors or galactosilated form of DA (GAL-DA). The aim of this study was to investigate whether GAL-DA would reduce hyperactivity and increase non-selective attention (NSA) in a mouse model of attention deficit hyperactivity disorder (ADHD), as, i.e. C57BL/6 as did in NHE rats. Here we report that GAL-DA increases NSA in a spatial novelty in C57BL/6 mice. They received a single i.p. injection of GAL-DA (10
mg/kg or 100
mg/kg) or equimolar galactose vehicle. Another mouse strain the Swiss albino was introduced as inbred control group. Three hours after last injection mice were tested in a Làt-maze for 30-min. Behaviour was analyzed for horizontal (traveled distance) and vertical activity (orienting frequency and scanning durations) which shares cognitive and non-cognitive nature, respectively. Ten milligram per kilograms of GAL-DA, increases scanning duration in C57BL/6 mice. Thus a low dose of GAL-DA increases NSA without reducing hyperactivity in this mouse model of ADHD.