Antinociceptive and anti-inflammatory activities of a sulfated polysaccharide isolated from the green seaweed Caulerpa cupressoides
Red and brown algae sulfated polysaccharides (SPs) have been widely investigated as antinociceptive and/or anti-inflammatory agents; however, no description of these biological properties concerning green algae SPs have been reported. Caulerpa curpressoides (Chlorophyta) presents three SPs fractions...
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| Published in: | Pharmacological reports Vol. 64; no. 2; pp. 282 - 292 |
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| Main Authors: | , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier Urban & Partner Sp. z o.o
2012
Springer International Publishing |
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| Abstract | Red and brown algae sulfated polysaccharides (SPs) have been widely investigated as antinociceptive and/or anti-inflammatory agents; however, no description of these biological properties concerning green algae SPs have been reported. Caulerpa curpressoides (Chlorophyta) presents three SPs fractions (Cc-SP1, Cc-SP2, and Cc-SP3). Anticoagulant (in vitro) and anti- and pro-thrombotic (in vivo) effects of Cc-SP2 had been recently reported. We evaluated the effects of Cc-SP2 using models of nociception and acute inflammation in vivo.
Male Swiss mice received Cc-SP2 (iv) 30min prior to receiving 0.6% acetic acid (10ml/kg, ip), 1% formalin (20μl, sc) or were subjected to thermal stimuli (51±1°C). Cc-SP2 was injected sc to male Wistar rats in a peritonitis model or a paw edema model using carrageenan (ip or ipl, 500μg). To analyze the systemic effects, Cc-SP2 (27mg/kg, sc) was administrated to both genders mice before waiting for 14 days.
Cc-SP2 (3, 9 or 27mg/kg) reduced (p<0.05) the number of writhes induced by acetic acid by 57, 89.9 and 90.6%, respectively, the licking time in the first (9 or 27mg/kg with 42.47 and 52.1%, respectively) and the second (3, 9 or 27mg/kg with 68.95, 82.34 and 84.61%, respectively) phases. In the hot-plate test, the antinociceptive effect of Cc-SP2 (9mg/kg) was primarily observed at 60min (26.7±1.2s), with its effect reversed by naloxone (8.6±1.3s), suggesting the involvement of the opioid system. Cc-SP2 (3, 9 or 27mg/kg, sc, p<0.05) showed anti-inflammatory effects by decreasing neutrophils migration by 64, 69 and 73%, respectively, and potently reduced the paw edema, especially at the second (0.16±0.02, 0.16±0.03 and 0.12±0.05ml) and third (0.16±0.03, 0.18±0.02 and 0.14±0.04ml) hours, respectively. Cc-SP2 did not cause hepatic or renal alterations or affect body mass or the macroscopy of the organs examined (p > 0.05). Histopathological analyses of the liver and kidney showed that both organs were affected by Cc-SP2 treatment, but these effects were considered reversible.
The results indicate that the analgesic and anti-inflammatory effects of Cc-SP2 could be of biomedical applicability as a new, natural tool in pain and acute inflammatory conditions. |
|---|---|
| AbstractList | Background
Red and brown algae sulfated polysaccharides (SPs) have been widely investigated as antinociceptive and/or antiinflammatory agents; however, no description of these biological properties concerning green algae SPs have been reported.
Caulerpa curpressoides
(Chlorophyta) presents three SPs fractions (Cc-SP1, Cc-SP2, and Cc-SP3). Anticoagulant (
in vitro
) and anti- and pro-thrombotic (
in vivo
) effects of Cc-SP2 had been recently reported.We evaluated the effects of Cc-SP2 using models of nociception and acute inflammation
in vivo
.
Methods
Male Swiss mice received Cc-SP2 (
iv
) 30 min prior to receiving 0.6% acetic acid (10 ml/kg,
ip
), 1% formalin (20 μl,
sc
) or were subjected to thermal stimuli (51 ± 1°C). Cc-SP2 was injected
sc
to maleWistar rats in a peritonitis model or a paw edema model using carrageenan (
ip
or
ipl
, 500 μg). To analyze the systemic effects, Cc-SP2 (27 mg/kg,
sc
) was administrated to both genders mice before waiting for 14 days.
Results
Cc-SP2 (3, 9 or 27 mg/kg) reduced (p < 0.05) the number of writhes induced by acetic acid by 57, 89.9 and 90.6%, respectively, the licking time in the first (9 or 27 mg/kg with 42.47 and 52.1%, respectively) and the second (3, 9 or 27 mg/kg with 68.95, 82.34 and 84.61%, respectively) phases. In the hot-plate test, the antinociceptive effect of Cc-SP2 (9 mg/kg) was primarily observed at 60 min (26.7 ± 1.2 s), with its effect reversed by naloxone (8.6 ± 1.3 s), suggesting the involvement of the opioid system. Cc-SP2 (3, 9 or 27 mg/kg,
sc
, p < 0.05) showed anti-inflammatory effects by decreasing neutrophils migration by 64, 69 and 73%, respectively, and potently reduced the paw edema, especially at the second (0.16 ± 0.02, 0.16 ± 0.03 and 0.12 ± 0.05 ml) and third (0.16 ± 0.03, 0.18 ± 0.02 and 0.14 ± 0.04 ml) hours, respectively. Cc-SP2 did not cause hepatic or renal alterations or affect body mass or the macroscopy of the organs examined (p > 0.05). Histopathological analyses of the liver and kidney showed that both organs were affected by Cc-SP2 treatment, but these effects were considered reversible.
Conclusion
The results indicate that the analgesic and anti-inflammatory effects of Cc-SP2 could be of biomedical applicability as a new, natural tool in pain and acute inflammatory conditions. BACKGROUNDRed and brown algae sulfated polysaccharides (SPs) have been widely investigated as antinociceptive and/or anti-inflammatory agents; however, no description of these biological properties concerning green algae SPs have been reported. Caulerpa curpressoides (Chlorophyta) presents three SPs fractions (Cc-SP1, Cc-SP2, and Cc-SP3). Anticoagulant (in vitro) and anti- and pro-thrombotic (in vivo) effects of Cc-SP2 had been recently reported. We evaluated the effects of Cc-SP2 using models of nociception and acute inflammation in vivo. METHODSMale Swiss mice received Cc-SP2 (iv) 30 min prior to receiving 0.6% acetic acid (10 ml/kg, ip), 1% formalin (20 μl, sc) or were subjected to thermal stimuli (51 ± 1 °C). Cc-SP2 was injected sc to male Wistar rats in a peritonitis model or a paw edema model using carrageenan (ip or ipl, 500 μg). To analyze the systemic effects, Cc-SP2 (27 mg/kg, sc) was administrated to both genders mice before waiting for 14 days. RESULTSCc-SP2 (3, 9 or 27 mg/kg) reduced (p < 0.05) the number of writhes induced by acetic acid by 57, 89.9 and 90.6%, respectively, the licking time in the first (9 or 27 mg/kg with 42.47 and 52.1%, respectively) and the second (3, 9 or 27 mg/kg with 68.95, 82.34 and 84.61%, respectively) phases. In the hot-plate test, the antinociceptive effect of Cc-SP2 (9 mg/kg) was primarily observed at 60 min (26.7 ± 1.2 s), with its effect reversed by naloxone (8.6 ± 1.3 s), suggesting the involvement of the opioid system. Cc-SP2 (3, 9 or 27 mg/kg, sc, p < 0.05) showed anti-inflammatory effects by decreasing neutrophils migration by 64, 69 and 73%, respectively, and potently reduced the paw edema, especially at the second (0.16 ± 0.02, 0.16 ± 0.03 and 0.12 ± 0.05 ml) and third (0.16 ± 0.03, 0.18 ± 0.02 and 0.14 ± 0.04 ml) hours, respectively. Cc-SP2 did not cause hepatic or renal alterations or affect body mass or the macroscopy of the organs examined (p > 0.05). Histopathological analyses of the liver and kidney showed that both organs were affected by Cc-SP2 treatment, but these effects were considered reversible. CONCLUSIONThe results indicate that the analgesic and anti-inflammatory effects of Cc-SP2 could be of biomedical applicability as a new, natural tool in pain and acute inflammatory conditions. Red and brown algae sulfated polysaccharides (SPs) have been widely investigated as antinociceptive and/or anti-inflammatory agents; however, no description of these biological properties concerning green algae SPs have been reported. Caulerpa curpressoides (Chlorophyta) presents three SPs fractions (Cc-SP1, Cc-SP2, and Cc-SP3). Anticoagulant (in vitro) and anti- and pro-thrombotic (in vivo) effects of Cc-SP2 had been recently reported. We evaluated the effects of Cc-SP2 using models of nociception and acute inflammation in vivo. Male Swiss mice received Cc-SP2 (iv) 30min prior to receiving 0.6% acetic acid (10ml/kg, ip), 1% formalin (20μl, sc) or were subjected to thermal stimuli (51±1°C). Cc-SP2 was injected sc to male Wistar rats in a peritonitis model or a paw edema model using carrageenan (ip or ipl, 500μg). To analyze the systemic effects, Cc-SP2 (27mg/kg, sc) was administrated to both genders mice before waiting for 14 days. Cc-SP2 (3, 9 or 27mg/kg) reduced (p<0.05) the number of writhes induced by acetic acid by 57, 89.9 and 90.6%, respectively, the licking time in the first (9 or 27mg/kg with 42.47 and 52.1%, respectively) and the second (3, 9 or 27mg/kg with 68.95, 82.34 and 84.61%, respectively) phases. In the hot-plate test, the antinociceptive effect of Cc-SP2 (9mg/kg) was primarily observed at 60min (26.7±1.2s), with its effect reversed by naloxone (8.6±1.3s), suggesting the involvement of the opioid system. Cc-SP2 (3, 9 or 27mg/kg, sc, p<0.05) showed anti-inflammatory effects by decreasing neutrophils migration by 64, 69 and 73%, respectively, and potently reduced the paw edema, especially at the second (0.16±0.02, 0.16±0.03 and 0.12±0.05ml) and third (0.16±0.03, 0.18±0.02 and 0.14±0.04ml) hours, respectively. Cc-SP2 did not cause hepatic or renal alterations or affect body mass or the macroscopy of the organs examined (p > 0.05). Histopathological analyses of the liver and kidney showed that both organs were affected by Cc-SP2 treatment, but these effects were considered reversible. The results indicate that the analgesic and anti-inflammatory effects of Cc-SP2 could be of biomedical applicability as a new, natural tool in pain and acute inflammatory conditions. Red and brown algae sulfated polysaccharides (SPs) have been widely investigated as antinociceptive and/or anti-inflammatory agents; however, no description of these biological properties concerning green algae SPs have been reported. Caulerpa curpressoides (Chlorophyta) presents three SPs fractions (Cc-SP1, Cc-SP2, and Cc-SP3). Anticoagulant (in vitro) and anti- and pro-thrombotic (in vivo) effects of Cc-SP2 had been recently reported. We evaluated the effects of Cc-SP2 using models of nociception and acute inflammation in vivo. Male Swiss mice received Cc-SP2 (iv) 30 min prior to receiving 0.6% acetic acid (10 ml/kg, ip), 1% formalin (20 μl, sc) or were subjected to thermal stimuli (51 ± 1 °C). Cc-SP2 was injected sc to male Wistar rats in a peritonitis model or a paw edema model using carrageenan (ip or ipl, 500 μg). To analyze the systemic effects, Cc-SP2 (27 mg/kg, sc) was administrated to both genders mice before waiting for 14 days. Cc-SP2 (3, 9 or 27 mg/kg) reduced (p < 0.05) the number of writhes induced by acetic acid by 57, 89.9 and 90.6%, respectively, the licking time in the first (9 or 27 mg/kg with 42.47 and 52.1%, respectively) and the second (3, 9 or 27 mg/kg with 68.95, 82.34 and 84.61%, respectively) phases. In the hot-plate test, the antinociceptive effect of Cc-SP2 (9 mg/kg) was primarily observed at 60 min (26.7 ± 1.2 s), with its effect reversed by naloxone (8.6 ± 1.3 s), suggesting the involvement of the opioid system. Cc-SP2 (3, 9 or 27 mg/kg, sc, p < 0.05) showed anti-inflammatory effects by decreasing neutrophils migration by 64, 69 and 73%, respectively, and potently reduced the paw edema, especially at the second (0.16 ± 0.02, 0.16 ± 0.03 and 0.12 ± 0.05 ml) and third (0.16 ± 0.03, 0.18 ± 0.02 and 0.14 ± 0.04 ml) hours, respectively. Cc-SP2 did not cause hepatic or renal alterations or affect body mass or the macroscopy of the organs examined (p > 0.05). Histopathological analyses of the liver and kidney showed that both organs were affected by Cc-SP2 treatment, but these effects were considered reversible. The results indicate that the analgesic and anti-inflammatory effects of Cc-SP2 could be of biomedical applicability as a new, natural tool in pain and acute inflammatory conditions. |
| Author | Abreu, Ticiana M. Bezerra, Mirna M. Vanderlei, Edfranck de S.O. Benevides, Norma M.B. Jorge, Roberta J.B. Monteiro, Helena S.A. Chaves, Hellíada V. Rodrigues, José A.G. Silva, Luana M.C.M. de Queiroz, Ismael N.L. Leite, Edda L. de Araújo, Ianna W.F. Ribeiro, Natássia A. de Paula, Gabriela A. Lima, Vilma |
| Author_xml | – sequence: 1 givenname: José A.G. surname: Rodrigues fullname: Rodrigues, José A.G. organization: Northeast Biotechnology Network, Federal University of Ceará, Campus do Pici, Fortaleza, Ceará, Av. Mister Hull, CEP: 60455-760, Brazil – sequence: 2 givenname: Edfranck de S.O. surname: Vanderlei fullname: Vanderlei, Edfranck de S.O. organization: Department of Biochemistry and Molecular Biology, Bloco 907, Federal University of Ceará, Campus do Pici, Fortaleza, Ceará, Av. Mister Hull, CEP: 60455-760, Brazil – sequence: 3 givenname: Luana M.C.M. surname: Silva fullname: Silva, Luana M.C.M. organization: Department of Biochemistry and Molecular Biology, Bloco 907, Federal University of Ceará, Campus do Pici, Fortaleza, Ceará, Av. Mister Hull, CEP: 60455-760, Brazil – sequence: 4 givenname: Ianna W.F. surname: de Araújo fullname: de Araújo, Ianna W.F. organization: Northeast Biotechnology Network, Federal University of Ceará, Campus do Pici, Fortaleza, Ceará, Av. Mister Hull, CEP: 60455-760, Brazil – sequence: 5 givenname: Ismael N.L. surname: de Queiroz fullname: de Queiroz, Ismael N.L. organization: Department of Biochemistry and Molecular Biology, Bloco 907, Federal University of Ceará, Campus do Pici, Fortaleza, Ceará, Av. Mister Hull, CEP: 60455-760, Brazil – sequence: 6 givenname: Gabriela A. surname: de Paula fullname: de Paula, Gabriela A. organization: Northeast Biotechnology Network, Federal University of Ceará, Campus do Pici, Fortaleza, Ceará, Av. Mister Hull, CEP: 60455-760, Brazil – sequence: 7 givenname: Ticiana M. surname: Abreu fullname: Abreu, Ticiana M. organization: Department of Biochemistry and Molecular Biology, Bloco 907, Federal University of Ceará, Campus do Pici, Fortaleza, Ceará, Av. Mister Hull, CEP: 60455-760, Brazil – sequence: 8 givenname: Natássia A. surname: Ribeiro fullname: Ribeiro, Natássia A. organization: Department of Biochemistry and Molecular Biology, Bloco 907, Federal University of Ceará, Campus do Pici, Fortaleza, Ceará, Av. Mister Hull, CEP: 60455-760, Brazil – sequence: 9 givenname: Mirna M. surname: Bezerra fullname: Bezerra, Mirna M. organization: Faculty of Medicine, Federal University of Ceará, Av. Comte Maurocélio Rocha Pontes, no. 100, Sobral, Ceará, CEP: 62042-280, Brazil – sequence: 10 givenname: Hellíada V. surname: Chaves fullname: Chaves, Hellíada V. organization: Faculty of Medicine, Federal University of Ceará, Av. Comte Maurocélio Rocha Pontes, no. 100, Sobral, Ceará, CEP: 62042-280, Brazil – sequence: 11 givenname: Vilma surname: Lima fullname: Lima, Vilma organization: Department of Dentist Clinical, Facult of Pharmacy, Nursing and Dentistry, Federal University of Ceará, Rua: Cel. Nunes de Melo, no. 1127, Fortaleza, Ceará, CEP: 60431-970, Brazil – sequence: 12 givenname: Roberta J.B. surname: Jorge fullname: Jorge, Roberta J.B. organization: Department of Dentist Clinical, Facult of Pharmacy, Nursing and Dentistry, Federal University of Ceará, Rua: Cel. Nunes de Melo, no. 1127, Fortaleza, Ceará, CEP: 60431-970, Brazil – sequence: 13 givenname: Helena S.A. surname: Monteiro fullname: Monteiro, Helena S.A. organization: Department of Dentist Clinical, Facult of Pharmacy, Nursing and Dentistry, Federal University of Ceará, Rua: Cel. Nunes de Melo, no. 1127, Fortaleza, Ceará, CEP: 60431-970, Brazil – sequence: 14 givenname: Edda L. surname: Leite fullname: Leite, Edda L. organization: Department of Biochemistry, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, Lagoa Nova, Natal, Rio Grande do Norte, CEP:59072-970, Brazil – sequence: 15 givenname: Norma M.B. surname: Benevides fullname: Benevides, Norma M.B. email: nmbb@ufc.br organization: Northeast Biotechnology Network, Federal University of Ceará, Campus do Pici, Fortaleza, Ceará, Av. Mister Hull, CEP: 60455-760, Brazil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22661177$$D View this record in MEDLINE/PubMed |
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| Copyright | 2012 Institute of Pharmacology Polish Academy of Sciences Maj Institute of Pharmacology, Polish Academy of Sciences 2012 |
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| PublicationYear | 2012 |
| Publisher | Elsevier Urban & Partner Sp. z o.o Springer International Publishing |
| Publisher_xml | – name: Elsevier Urban & Partner Sp. z o.o – name: Springer International Publishing |
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| Snippet | Red and brown algae sulfated polysaccharides (SPs) have been widely investigated as antinociceptive and/or anti-inflammatory agents; however, no description of... Background Red and brown algae sulfated polysaccharides (SPs) have been widely investigated as antinociceptive and/or antiinflammatory agents; however, no... BACKGROUNDRed and brown algae sulfated polysaccharides (SPs) have been widely investigated as antinociceptive and/or anti-inflammatory agents; however, no... |
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| SubjectTerms | Acute Disease Animals Anti-Inflammatory Agents, Non-Steroidal - adverse effects Anti-Inflammatory Agents, Non-Steroidal - isolation & purification Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Caulerpa - chemistry Caulerpa cupressoides Chlorophyta - chemistry Disease Models, Animal Drug Safety and Pharmacovigilance Edema - drug therapy Female Heart - drug effects inflammation Kidney - drug effects Kidney - pathology Liver - drug effects Liver - pathology Male marine alga Mice Myocardium - pathology nociception Pain - drug therapy Pain Measurement Peritonitis - drug therapy Pharmacotherapy Pharmacy Polysaccharides - adverse effects Polysaccharides - isolation & purification Polysaccharides - therapeutic use Rats Rats, Wistar sulfated polysaccharide |
| Title | Antinociceptive and anti-inflammatory activities of a sulfated polysaccharide isolated from the green seaweed Caulerpa cupressoides |
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