The microinjection of AMPA receptor antagonist into the accumbens shell, but not into the accumbens core, induces anxiolysis in an animal model of anxiety

This study investigated the effect of the AMPA receptor antagonist 6,7-dinitroquinoxaline-2,3-dione (DNQX) microinjected into the core and shell sub-regions of the accumbens nucleus (Acb), on the level of fear/anxiety and emotional learning, in female rats submitted to the elevated plus-maze (EPM),...

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Bibliographic Details
Published in:	Behavioural brain research Vol. 188; no. 1; pp. 91 - 99
Main Authors:	da Cunha, Isabel Cristina, Lopes, Ana Paula Fraga, Steffens, Sergio Murilo, Ferraz, Adriana, Vargas, Juliano Cordova, de Lima, Thereza Christina Monteiro, Marino Neto, José, Paschoalini, Marta Aparecida, Faria, Moacir Serralvo
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier B.V 17-03-2008 Elsevier Science
Subjects:	Accumbens AMPA Analysis of Variance Animals Anxiety Anxiety - chemically induced Anxiety - metabolism Avoidance Learning - drug effects Avoidance Learning - physiology Behavioral psychophysiology Biological and medical sciences Dose-Response Relationship, Drug Elevated plus-maze Excitatory Amino Acid Antagonists - administration & dosage Exploratory Behavior - drug effects Exploratory Behavior - physiology Fear Fear - drug effects Fear - physiology Female Fundamental and applied biological sciences. Psychology Glutamate Microinjections Nucleus Accumbens - anatomy & histology Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Quinoxalines - administration & dosage Rat Rats Rats, Wistar Receptors, AMPA - antagonists & inhibitors Receptors, AMPA - metabolism Fear Accumbens AMPA Rat Anxiety Elevated plus-maze Glutamate Affect affectivity Animal model Rodentia Glutamate receptor Emotion emotionality Vertebrata AMPA receptor Mammalia Animal Excitatory aminoacid Neurotransmitter Antagonist
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