Rapid method for the detection of rodenticides in contaminated foods
•Rodenticides pose significant poisoning risks to humans and animals.•Solid-liquid extraction, dispersive-solid phase cleanup was applied to food matrices.•Identification by liquid chromatography tandem mass spectrometry in negative ion mode.•Analysis method was successfully applied to a real-world...
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| Published in: | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Vol. 1186; p. 123005 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
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01-12-2021
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| Abstract | •Rodenticides pose significant poisoning risks to humans and animals.•Solid-liquid extraction, dispersive-solid phase cleanup was applied to food matrices.•Identification by liquid chromatography tandem mass spectrometry in negative ion mode.•Analysis method was successfully applied to a real-world contamination case study.
Rodenticides are toxic chemicals used to control rodent populations and are among the most common household toxicants. Ingestion of foods contaminated with rodenticides may cause severe illness or death in humans and animals. A rapid analytical method was developed for the identification of nine common rodenticides in foods using solid–liquid extraction followed by dispersive-solid phase extraction prior to the analysis by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and UV detection. The method validation on a variety of food matrices including cornmeal, peanut, whole wheat flour and pork liver produced average recoveries between 91.2 and 107% with relative standard deviations between 2.6 and 14% for all studied rodenticides. The method detection limits ranged from 2.7 to 8.2 μg/kg (ppb) for eight rodenticides analyzed by LC-MS/MS and between 0.10 and 0.21 mg/kg (ppm) for bromethalin which was analyzed by LC with UV detection. This method could be useful in preparedness for emergency response situations involving widespread food contamination, terrorist acts or for forensic studies. |
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| AbstractList | •Rodenticides pose significant poisoning risks to humans and animals.•Solid-liquid extraction, dispersive-solid phase cleanup was applied to food matrices.•Identification by liquid chromatography tandem mass spectrometry in negative ion mode.•Analysis method was successfully applied to a real-world contamination case study.
Rodenticides are toxic chemicals used to control rodent populations and are among the most common household toxicants. Ingestion of foods contaminated with rodenticides may cause severe illness or death in humans and animals. A rapid analytical method was developed for the identification of nine common rodenticides in foods using solid–liquid extraction followed by dispersive-solid phase extraction prior to the analysis by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and UV detection. The method validation on a variety of food matrices including cornmeal, peanut, whole wheat flour and pork liver produced average recoveries between 91.2 and 107% with relative standard deviations between 2.6 and 14% for all studied rodenticides. The method detection limits ranged from 2.7 to 8.2 μg/kg (ppb) for eight rodenticides analyzed by LC-MS/MS and between 0.10 and 0.21 mg/kg (ppm) for bromethalin which was analyzed by LC with UV detection. This method could be useful in preparedness for emergency response situations involving widespread food contamination, terrorist acts or for forensic studies. Rodenticides are toxic chemicals used to control rodent populations and are among the most common household toxicants. Ingestion of foods contaminated with rodenticides may cause severe illness or death in humans and animals. A rapid analytical method was developed for the identification of nine common rodenticides in foods using solid-liquid extraction followed by dispersive-solid phase extraction prior to the analysis by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and UV detection. The method validation on a variety of food matrices including cornmeal, peanut, whole wheat flour and pork liver produced average recoveries between 91.2 and 107% with relative standard deviations between 2.6 and 14% for all studied rodenticides. The method detection limits ranged from 2.7 to 8.2 μg/kg (ppb) for eight rodenticides analyzed by LC-MS/MS and between 0.10 and 0.21 mg/kg (ppm) for bromethalin which was analyzed by LC with UV detection. This method could be useful in preparedness for emergency response situations involving widespread food contamination, terrorist acts or for forensic studies. |
| ArticleNumber | 123005 |
| Author | Neely, Sarah Tran, Buu N. Denn, Melinda Djatsa, Annie Okoniewski, Richard |
| Author_xml | – sequence: 1 givenname: Richard surname: Okoniewski fullname: Okoniewski, Richard – sequence: 2 givenname: Sarah surname: Neely fullname: Neely, Sarah – sequence: 3 givenname: Melinda surname: Denn fullname: Denn, Melinda – sequence: 4 givenname: Annie surname: Djatsa fullname: Djatsa, Annie – sequence: 5 givenname: Buu N. surname: Tran fullname: Tran, Buu N. email: buu.tran@health.ny.gov |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34741935$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_cbpc_2024_109841 crossref_primary_10_1021_acsomega_3c00005 crossref_primary_10_1016_j_foodchem_2023_137792 crossref_primary_10_1186_s42269_023_01055_4 crossref_primary_10_1007_s00216_022_04145_w |
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| Copyright | 2021 Elsevier B.V. Copyright © 2021 Elsevier B.V. All rights reserved. |
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| Keywords | LC-MS/MS Anticoagulant rodenticides Poisoning Brodifacoum Dispersive-solid phase extraction |
| Language | English |
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| Snippet | •Rodenticides pose significant poisoning risks to humans and animals.•Solid-liquid extraction, dispersive-solid phase cleanup was applied to food... Rodenticides are toxic chemicals used to control rodent populations and are among the most common household toxicants. Ingestion of foods contaminated with... |
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| SubjectTerms | Animals Anticoagulant rodenticides Brodifacoum Chromatography, High Pressure Liquid - methods Dispersive-solid phase extraction Flour - analysis Food Contamination - analysis LC-MS/MS Liver - chemistry Poisoning Rodenticides - analysis Rodenticides - isolation & purification Solid Phase Extraction - methods Swine Tandem Mass Spectrometry - methods Triticum - chemistry |
| Title | Rapid method for the detection of rodenticides in contaminated foods |
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