Higher insulin sensitivity in EDL muscle of rats fed a low-protein, high-carbohydrate diet inhibits the caspase-3 and ubiquitin-proteasome proteolytic systems but does not increase protein synthesis

Compared with the extensor digitorum longus (EDL) muscle of control rats (C), the EDL muscle of rats fed a low-protein, high-carbohydrate diet (LPHC) showed a 36% reduction in mass. Muscle mass is determined by the balance between protein synthesis and proteolysis; thus, the aim of this work was to...

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Bibliographic Details
Published in:	The Journal of nutritional biochemistry Vol. 34; pp. 89 - 98
Main Authors:	dos Santos, Maísa Pavani, Batistela, Emanuele, Pereira, Mayara Peron, Paula-Gomes, Silvia, Zanon, Neusa Maria, Kettelhut, Isis do Carmo, Karatzaferi, Christina, Andrade, Claudia Marlise Balbinotti, de França, Suélem Aparecida, Baviera, Amanda Martins, Kawashita, Nair Honda
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-08-2016
Subjects:	Animals Carrier Proteins - genetics Carrier Proteins - metabolism Caspase 3 - metabolism Diet, Carbohydrate Loading - adverse effects Diet, Protein-Restricted - adverse effects Down-Regulation Extensor digitorum longus Foot Growing rats Insulin Resistance Insulin sensitivity Low-protein, high-carbohydrate diet Male Muscle Development Muscle, Skeletal - enzymology Muscle, Skeletal - metabolism Phosphoproteins - genetics Phosphoproteins - metabolism Phosphorylation Proteasome Endopeptidase Complex - metabolism Protein Biosynthesis Protein Processing, Post-Translational Protein synthesis Protein Tyrosine Phosphatases - genetics Protein Tyrosine Phosphatases - metabolism Proteolysis Proteolytic pathways Random Allocation Rats, Wistar Ribosomal Protein S6 Kinases, 70-kDa - genetics Ribosomal Protein S6 Kinases, 70-kDa - metabolism Ubiquitination Extensor digitorum longus Protein synthesis Insulin sensitivity Proteolytic pathways Low-protein, high-carbohydrate diet Growing rats
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