Chronic lymphocytic leukemia presenting as a pituitary mass lesion

We describe a unique case of chronic lymphocytic leukemia (CLL) in a patient who presented with bitemporal hemianopsia, adrenal insufficiency, and gonadotrophin deficiency. Studies revealed an enhancing intrasellar mass with suprasellar extension and displacement of the optic chiasm. Peripheral bloo...

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Bibliographic Details
Published in:	Canadian journal of neurological sciences Vol. 19; no. 2; p. 239
Main Authors:	Fain, J S, Naeim, F, Becker, D P, Van Herle, A, Yan-Go, F, Petrus, L, Vinters, H V
Format:	Journal Article
Language:	English
Published:	England 01-05-1992
Subjects:	Brain - diagnostic imaging Female Humans Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis Leukemia, Lymphocytic, Chronic, B-Cell - diagnostic imaging Leukemia, Lymphocytic, Chronic, B-Cell - pathology Liver - diagnostic imaging Middle Aged Optic Chiasm - pathology Pituitary Neoplasms - diagnostic imaging Pituitary Neoplasms - pathology Radionuclide Imaging Spleen - diagnostic imaging Tomography, X-Ray Computed
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Summary:	We describe a unique case of chronic lymphocytic leukemia (CLL) in a patient who presented with bitemporal hemianopsia, adrenal insufficiency, and gonadotrophin deficiency. Studies revealed an enhancing intrasellar mass with suprasellar extension and displacement of the optic chiasm. Peripheral blood and cerebrospinal fluid (CSF) studies disclosed a monoclonal IgM kappa expressing B-cell CLL. Biopsy of the pituitary mass revealed dense infiltration of the pituitary gland by leukemic cells. This is, to our knowledge, the first reported case of CLL presenting as a pituitary mass lesion.
ISSN:	0317-1671
DOI:	10.1017/S0317167100042335