From Spherical to Osmotically Shrunken Paramagnetic Liposomes: An Improved Generation of LIPOCEST MRI Agents with Highly Shifted Water Protons

Honey, I shrunk the …︁ The chemical shift of intraliposomal water protons of LIPOCEST MRI agents may be enhanced by exploiting a contribution arising from bulk magnetic susceptibility. The effect was attained by osmotically shrinking liposomes to attain nonspherical compartments, with the largest sh...

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Bibliographic Details
Published in:	Angewandte Chemie International Edition Vol. 46; no. 6; pp. 966 - 968
Main Authors:	Terreno, Enzo, Cabella, Claudia, Carrera, Carla, Delli Castelli, Daniela, Mazzon, Roberta, Rollet, Simona, Stancanello, Joseph, Visigalli, Massimo, Aime, Silvio
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 01-01-2007 WILEY‐VCH Verlag
Subjects:	Contrast Media - chemical synthesis Contrast Media - chemistry imaging agents lanthanides Lanthanoid Series Elements - chemistry liposomes Liposomes - chemistry magnetic properties Magnetic Resonance Imaging Magnetic Resonance Spectroscopy - methods Magnetics Molecular Structure Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Osmotic Pressure Phantoms, Imaging Protons shift reagents Water - chemistry
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Summary:	Honey, I shrunk the …︁ The chemical shift of intraliposomal water protons of LIPOCEST MRI agents may be enhanced by exploiting a contribution arising from bulk magnetic susceptibility. The effect was attained by osmotically shrinking liposomes to attain nonspherical compartments, with the largest shifts observed for systems containing paramagnetic Tm or Dy complexes either entrapped in the inner cavity or incorporated in the liposome membrane (see picture).
Bibliography:	istex:8C638A74B0D74D29B5F27296470F3E948A8FDCCD ark:/67375/WNG-9NSR3P5Q-7 This work was funded by the EC-FP6-projects DiMI (LSHB-CT-2005-512146) and EMIL (LSHC-CT-2004-503569). Scientific support from EU-COST D18 action is also gratefully acknowledged. EC-FP6-projects DiMI - No. LSHB-CT-2005-512146 EMIL - No. LSHC-CT-2004-503569 ArticleID:ANIE200604027 This work was funded by the EC‐FP6‐projects DiMI (LSHB‐CT‐2005‐512146) and EMIL (LSHC‐CT‐2004‐503569). Scientific support from EU‐COST D18 action is also gratefully acknowledged. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200604027