A rapid assay for mitochondrial DNA damage and respiratory chain inhibition in the yeast Saccharomyces cerevisiae

There is a need for a rapid assay to identify agents that damage mitochondria because the mitochondrion may be an important target for numerous environmental mitotoxins. Certainly at least one chemotherapeutic regimen (CHOP therapy) that includes doxorubicin can induce cardiomyopathy through mitocho...

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Bibliographic Details
Published in:	Environmental and molecular mutagenesis Vol. 38; no. 2-3; pp. 153 - 158
Main Authors:	Barclay, Barry J., DeHaan, Carrie L., Hennig, Ursula G.G., Iavorovska, Oksana, von Borstel, Reid W., von Borstel, R.C.
Format:	Journal Article
Language:	English
Published:	New York John Wiley & Sons, Inc 2001 Wiley-Liss
Subjects:	4-hydroxycyclophosphamide 5-Fluorocytosine 5-fluorouracil 6-chloro analog of pyrvinium iodide Biological and medical sciences Biological Assay DNA Damage DNA, Mitochondrial - drug effects DNA, Mitochondrial - genetics doxorubicin Electron Transport - drug effects Electron Transport - genetics erythromycin ethidium bromide Fundamental and applied biological sciences. Psychology methotrexate mitochondria Molecular and cellular biology Molecular genetics Mutagenesis. Repair Mutagens - toxicity petite cells pyrvinium iodide pyrvinium pamoate rho− cells Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics thiabendazole yeast Fungi Respiratory chain Yeast DNA Ascomycetes Mitochondrial DNA Inhibition Saccharomyces cerevisiae Thallophyta
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