Cytokine profiling and post‐transfusion haemoglobin increment in patients with haematological diseases
Background and Objectives In a previous pilot study, we demonstrated significantly lower haemoglobin (Hb) increment after red‐blood‐cell (RBC) transfusions in febrile patients compared to patients without fever. The aim of this study was to examine associations between inflammatory mediators and pos...
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| Published in: | Vox sanguinis Vol. 113; no. 7; pp. 657 - 668 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
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England
S. Karger AG
01-10-2018
Wiley |
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| Abstract | Background and Objectives
In a previous pilot study, we demonstrated significantly lower haemoglobin (Hb) increment after red‐blood‐cell (RBC) transfusions in febrile patients compared to patients without fever. The aim of this study was to examine associations between inflammatory mediators and post‐transfusion haemoglobin increment in patients with haematological diseases.
Materials and Methods
Twenty‐seven patients (eight women, 19 men), median age 56 years receiving RBC transfusion, were included in the study. Hb increment per unit transfused was corrected for estimated patient blood volume and the amount of Hb transfused. A wide spectrum of inflammatory mediators was determined by multiplex technology. Association between post‐transfusion haemoglobin increment, plasma inflammatory mediators and patient characteristics was analysed using a mixed linear regression model.
Results
Febrile patients had significantly lower corrected Hb increment, significantly increased values of IL‐6, IL‐8, IL‐10 and G‐CSF, significantly reduced levels of CCL5 and CXCL10, and significantly higher pretransfusion levels of CRP. There was a significant association between pretransfusion CRP levels and corrected Hb increment for the whole patient cohort, but not within each of the two groups. Results demonstrated an association between haemoglobin increment, fever and inflammatory mediators. Febrile patients had a significantly lower corrected Hb increment compared to nonfebrile patients, when adjusting for mediators. When fever was kept constant, a significant negative association between haemoglobin increment and the proinflammatory mediators IL‐6 and IL‐8 was observed.
Conclusion
Both fever and the inflammatory mediators IL‐6 and IL‐8 were negatively associated with post‐transfusion haemoglobin increment. |
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| AbstractList | In a previous pilot study, we demonstrated significantly lower haemoglobin (Hb) increment after red-blood-cell (RBC) transfusions in febrile patients compared to patients without fever. The aim of this study was to examine associations between inflammatory mediators and post-transfusion haemoglobin increment in patients with haematological diseases.
Twenty-seven patients (eight women, 19 men), median age 56 years receiving RBC transfusion, were included in the study. Hb increment per unit transfused was corrected for estimated patient blood volume and the amount of Hb transfused. A wide spectrum of inflammatory mediators was determined by multiplex technology. Association between post-transfusion haemoglobin increment, plasma inflammatory mediators and patient characteristics was analysed using a mixed linear regression model.
Febrile patients had significantly lower corrected Hb increment, significantly increased values of IL-6, IL-8, IL-10 and G-CSF, significantly reduced levels of CCL5 and CXCL10, and significantly higher pretransfusion levels of CRP. There was a significant association between pretransfusion CRP levels and corrected Hb increment for the whole patient cohort, but not within each of the two groups. Results demonstrated an association between haemoglobin increment, fever and inflammatory mediators. Febrile patients had a significantly lower corrected Hb increment compared to nonfebrile patients, when adjusting for mediators. When fever was kept constant, a significant negative association between haemoglobin increment and the proinflammatory mediators IL-6 and IL-8 was observed.
Both fever and the inflammatory mediators IL-6 and IL-8 were negatively associated with post-transfusion haemoglobin increment. Background and ObjectivesIn a previous pilot study, we demonstrated significantly lower haemoglobin (Hb) increment after red‐blood‐cell (RBC) transfusions in febrile patients compared to patients without fever. The aim of this study was to examine associations between inflammatory mediators and post‐transfusion haemoglobin increment in patients with haematological diseases.Materials and MethodsTwenty‐seven patients (eight women, 19 men), median age 56 years receiving RBC transfusion, were included in the study. Hb increment per unit transfused was corrected for estimated patient blood volume and the amount of Hb transfused. A wide spectrum of inflammatory mediators was determined by multiplex technology. Association between post‐transfusion haemoglobin increment, plasma inflammatory mediators and patient characteristics was analysed using a mixed linear regression model.ResultsFebrile patients had significantly lower corrected Hb increment, significantly increased values of IL‐6, IL‐8, IL‐10 and G‐CSF, significantly reduced levels of CCL5 and CXCL10, and significantly higher pretransfusion levels of CRP. There was a significant association between pretransfusion CRP levels and corrected Hb increment for the whole patient cohort, but not within each of the two groups. Results demonstrated an association between haemoglobin increment, fever and inflammatory mediators. Febrile patients had a significantly lower corrected Hb increment compared to nonfebrile patients, when adjusting for mediators. When fever was kept constant, a significant negative association between haemoglobin increment and the proinflammatory mediators IL‐6 and IL‐8 was observed.ConclusionBoth fever and the inflammatory mediators IL‐6 and IL‐8 were negatively associated with post‐transfusion haemoglobin increment. Background and Objectives: In a previous pilot study, we demonstrated significantly lower haemoglobin (Hb) increment after red‐blood‐cell (RBC) transfusions in febrile patients compared to patients without fever. The aim of this study was to examine associations between inflammatory mediators and post‐transfusion haemoglobin increment in patients with haematological diseases. Materials and Methods: Twenty‐seven patients (eight women, 19 men), median age 56 years receiving RBC transfusion, were included in the study. Hb increment per unit transfused was corrected for estimated patient blood volume and the amount of Hb transfused. A wide spectrum of inflammatory mediators was determined by multiplex technology. Association between post‐transfusion haemoglobin increment, plasma inflammatory mediators and patient characteristics was analysed using a mixed linear regression model. Results: Febrile patients had significantly lower corrected Hb increment, significantly increased values of IL‐6, IL‐8, IL‐10 and G‐CSF, significantly reduced levels of CCL5 and CXCL10, and significantly higher pretransfusion levels of CRP. There was a significant association between pretransfusion CRP levels and corrected Hb increment for the whole patient cohort, but not within each of the two groups. Results demonstrated an association between haemoglobin increment, fever and inflammatory mediators. Febrile patients had a significantly lower corrected Hb increment compared to nonfebrile patients, when adjusting for mediators. When fever was kept constant, a significant negative association between haemoglobin increment and the proinflammatory mediators IL‐6 and IL‐8 was observed. Conclusion: Both fever and the inflammatory mediators IL‐6 and IL‐8 were negatively associated with post‐transfusion haemoglobin increment. Background and Objectives In a previous pilot study, we demonstrated significantly lower haemoglobin (Hb) increment after red‐blood‐cell (RBC) transfusions in febrile patients compared to patients without fever. The aim of this study was to examine associations between inflammatory mediators and post‐transfusion haemoglobin increment in patients with haematological diseases. Materials and Methods Twenty‐seven patients (eight women, 19 men), median age 56 years receiving RBC transfusion, were included in the study. Hb increment per unit transfused was corrected for estimated patient blood volume and the amount of Hb transfused. A wide spectrum of inflammatory mediators was determined by multiplex technology. Association between post‐transfusion haemoglobin increment, plasma inflammatory mediators and patient characteristics was analysed using a mixed linear regression model. Results Febrile patients had significantly lower corrected Hb increment, significantly increased values of IL‐6, IL‐8, IL‐10 and G‐CSF, significantly reduced levels of CCL5 and CXCL10, and significantly higher pretransfusion levels of CRP. There was a significant association between pretransfusion CRP levels and corrected Hb increment for the whole patient cohort, but not within each of the two groups. Results demonstrated an association between haemoglobin increment, fever and inflammatory mediators. Febrile patients had a significantly lower corrected Hb increment compared to nonfebrile patients, when adjusting for mediators. When fever was kept constant, a significant negative association between haemoglobin increment and the proinflammatory mediators IL‐6 and IL‐8 was observed. Conclusion Both fever and the inflammatory mediators IL‐6 and IL‐8 were negatively associated with post‐transfusion haemoglobin increment. |
| Author | Wendelbo, Øystein Bruserud, Øystein Mollnes, Tom Eirik Opheim, Elin Netland Hervig, Tor Reikvam, Håkon Felli Lunde, Turid Helen |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30159896$$D View this record in MEDLINE/PubMed |
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In a previous pilot study, we demonstrated significantly lower haemoglobin (Hb) increment after red‐blood‐cell (RBC) transfusions in... In a previous pilot study, we demonstrated significantly lower haemoglobin (Hb) increment after red-blood-cell (RBC) transfusions in febrile patients compared... Background and ObjectivesIn a previous pilot study, we demonstrated significantly lower haemoglobin (Hb) increment after red‐blood‐cell (RBC) transfusions in... BACKGROUND AND OBJECTIVESIn a previous pilot study, we demonstrated significantly lower haemoglobin (Hb) increment after red-blood-cell (RBC) transfusions in... Background and Objectives: In a previous pilot study, we demonstrated significantly lower haemoglobin (Hb) increment after red‐blood‐cell (RBC) transfusions in... |
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| SubjectTerms | Adult Aged Blood volume Clinical medical disciplines: 750 CXCL10 protein Erythrocyte Transfusion Erythrocytes Female Fever Fever - blood Hematologi: 775 Hematologic Diseases - blood Hematologic Diseases - therapy Hematology Hematology: 775 Hemoglobin Hemoglobins - analysis Humans Inflammation Interleukins - blood Klinisk medisinske fag: 750 Male Medical disciplines: 700 Medisinske Fag: 700 Middle Aged Patients red‐blood‐cell concentrates Regression analysis Regression models Transfusion VDP |
| Title | Cytokine profiling and post‐transfusion haemoglobin increment in patients with haematological diseases |
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