Control of an outbreak of Acinetobacter baumannii infections using vaporized hydrogen peroxide
Summary Background Multidrug-resistant Acinetobacter baumannii (MRAB) is a serious nosocomial pathogen characterized by its survival on inanimate surfaces for long periods, making control of outbreaks difficult. Aim To analyse two hospital outbreaks caused by MRAB, determine their epidemiology, carb...
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| Published in: | The Journal of hospital infection Vol. 81; no. 4; pp. 239 - 245 |
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| Abstract | Summary Background Multidrug-resistant Acinetobacter baumannii (MRAB) is a serious nosocomial pathogen characterized by its survival on inanimate surfaces for long periods, making control of outbreaks difficult. Aim To analyse two hospital outbreaks caused by MRAB, determine their epidemiology, carbapenem-resistance mechanisms and assess the effectiveness of surface disinfection by vaporized hydrogen peroxide (VHP). Methods MRAB strains were isolated from patients in two intensive care units (ICUs). Antimicrobial susceptibility testing was performed by E-test. Polymerase chain reaction (PCR) was used to detect the presence of the most common A. baumannii carbapenemases. Epidemiological typing was performed by rep-PCR (DiversiLab) and pulsed-field gel electrophoresis. VHP was used to decontaminate the affected ICUs. Findings MRAB was isolated from 28 patients between January 2009 and September 2010. All isolates were resistant to ciprofloxacin and gentamicin. Twenty-one were also resistant to carbapenems. Carbapenem resistance was associated primarily with the acquired OXA-23-like enzyme. Genotyping revealed three clones; the predominant clone corresponded to the international clone (IC) 2. Typing of the isolates pointed to a multifocal outbreak without a single source of infection, with horizontal spread of the dominating clone among ICU patients. A combination of rigorous infection control measures including strict isolation, education of staff, hand hygiene and surface decontamination using VHP halted the outbreak. Conclusion The results of this study confirm the importance of rigorous infection prevention and control measures, combined with VHP decontamination in controlling an outbreak of MRAB. |
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| AbstractList | Multidrug-resistant Acinetobacter baumannii (MRAB) is a serious nosocomial pathogen characterized by its survival on inanimate surfaces for long periods, making control of outbreaks difficult.
To analyse two hospital outbreaks caused by MRAB, determine their epidemiology, carbapenem-resistance mechanisms and assess the effectiveness of surface disinfection by vaporized hydrogen peroxide (VHP).
MRAB strains were isolated from patients in two intensive care units (ICUs). Antimicrobial susceptibility testing was performed by E-test. Polymerase chain reaction (PCR) was used to detect the presence of the most common A. baumannii carbapenemases. Epidemiological typing was performed by rep-PCR (DiversiLab) and pulsed-field gel electrophoresis. VHP was used to decontaminate the affected ICUs.
MRAB was isolated from 28 patients between January 2009 and September 2010. All isolates were resistant to ciprofloxacin and gentamicin. Twenty-one were also resistant to carbapenems. Carbapenem resistance was associated primarily with the acquired OXA-23-like enzyme. Genotyping revealed three clones; the predominant clone corresponded to the international clone (IC) 2. Typing of the isolates pointed to a multifocal outbreak without a single source of infection, with horizontal spread of the dominating clone among ICU patients. A combination of rigorous infection control measures including strict isolation, education of staff, hand hygiene and surface decontamination using VHP halted the outbreak.
The results of this study confirm the importance of rigorous infection prevention and control measures, combined with VHP decontamination in controlling an outbreak of MRAB. BACKGROUNDMultidrug-resistant Acinetobacter baumannii (MRAB) is a serious nosocomial pathogen characterized by its survival on inanimate surfaces for long periods, making control of outbreaks difficult.AIMTo analyse two hospital outbreaks caused by MRAB, determine their epidemiology, carbapenem-resistance mechanisms and assess the effectiveness of surface disinfection by vaporized hydrogen peroxide (VHP).METHODSMRAB strains were isolated from patients in two intensive care units (ICUs). Antimicrobial susceptibility testing was performed by E-test. Polymerase chain reaction (PCR) was used to detect the presence of the most common A. baumannii carbapenemases. Epidemiological typing was performed by rep-PCR (DiversiLab) and pulsed-field gel electrophoresis. VHP was used to decontaminate the affected ICUs.FINDINGSMRAB was isolated from 28 patients between January 2009 and September 2010. All isolates were resistant to ciprofloxacin and gentamicin. Twenty-one were also resistant to carbapenems. Carbapenem resistance was associated primarily with the acquired OXA-23-like enzyme. Genotyping revealed three clones; the predominant clone corresponded to the international clone (IC) 2. Typing of the isolates pointed to a multifocal outbreak without a single source of infection, with horizontal spread of the dominating clone among ICU patients. A combination of rigorous infection control measures including strict isolation, education of staff, hand hygiene and surface decontamination using VHP halted the outbreak.CONCLUSIONThe results of this study confirm the importance of rigorous infection prevention and control measures, combined with VHP decontamination in controlling an outbreak of MRAB. Summary Background Multidrug-resistant Acinetobacter baumannii (MRAB) is a serious nosocomial pathogen characterized by its survival on inanimate surfaces for long periods, making control of outbreaks difficult. Aim To analyse two hospital outbreaks caused by MRAB, determine their epidemiology, carbapenem-resistance mechanisms and assess the effectiveness of surface disinfection by vaporized hydrogen peroxide (VHP). Methods MRAB strains were isolated from patients in two intensive care units (ICUs). Antimicrobial susceptibility testing was performed by E-test. Polymerase chain reaction (PCR) was used to detect the presence of the most common A. baumannii carbapenemases. Epidemiological typing was performed by rep-PCR (DiversiLab) and pulsed-field gel electrophoresis. VHP was used to decontaminate the affected ICUs. Findings MRAB was isolated from 28 patients between January 2009 and September 2010. All isolates were resistant to ciprofloxacin and gentamicin. Twenty-one were also resistant to carbapenems. Carbapenem resistance was associated primarily with the acquired OXA-23-like enzyme. Genotyping revealed three clones; the predominant clone corresponded to the international clone (IC) 2. Typing of the isolates pointed to a multifocal outbreak without a single source of infection, with horizontal spread of the dominating clone among ICU patients. A combination of rigorous infection control measures including strict isolation, education of staff, hand hygiene and surface decontamination using VHP halted the outbreak. Conclusion The results of this study confirm the importance of rigorous infection prevention and control measures, combined with VHP decontamination in controlling an outbreak of MRAB. |
| Author | Chmielarczyk, A Zander, E Heczko, P Higgins, P.G Bulanda, M Gosiewski, T Romaniszyn, D Seifert, H Wojkowska-Mach, J Synowiec, E |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22727825$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1093/jac/dkp428 10.1038/nrmicro1789 10.1016/j.jhin.2010.12.006 10.1128/CMR.00058-07 10.1111/j.1469-0691.2007.01694.x 10.1086/502205 10.1016/j.ijantimicag.2008.02.016 10.1128/JCM.43.9.4328-4335.2005 10.1086/533545 10.1111/j.1469-0691.2007.01819.x 10.1016/j.jhin.2007.06.004 10.1016/j.ijantimicag.2006.01.004 10.1111/j.1574-6968.2006.00195.x 10.1128/JCM.01971-06 10.1016/j.ajic.2007.10.007 10.1111/j.1469-0691.2009.02668.x 10.1086/503164 10.1016/j.jhin.2007.05.009 10.1016/j.diagmicrobio.2010.10.020 10.1086/505599 10.1086/591062 10.1111/j.1469-0691.2004.00942.x 10.1016/j.ajic.2009.07.012 10.1086/657139 10.1086/501852 10.1086/521660 10.1016/j.ajic.2008.03.002 10.1111/j.1440-1843.2007.01147.x |
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| Keywords | Hospital-acquired infection Multidrug-resistant Acinetobacter baumannii Outbreak Vaporized hydrogen peroxide |
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| References | D'Arezzo, Capone, Petrosillo (bib24) 2009; 15 Horan, Andrus, Dudeck (bib8) 2008; 36 AB bioMérieux. Hardy, Gossain, Henderson (bib31) 2007; 66 Ray, Perez, Beltramini (bib32) 2010; 31 Leclercq, Cantón, Brown (bib10) 2012 Peleg, Seifert, Paterson (bib2) 2008; 21 Markogiannakis, Fildisis, Tsiplakou (bib23) 2008; 29 Siegel, Rhinehart, Jackson, Chiarello (bib19) 2007; 12 Sax, Allegranzi, Uçkay, Larson, Boyce, Pittet (bib20) 2007; 67 Villegas, Hartstein (bib3) 2003; 24 Woodford, Ellington, Coelho (bib13) 2006; 27 Valenzuela, Thomas, Partridge, van der Reijden, Dijkshoorn, Iredell (bib30) 2007; 45 Dijkshoorn, Nemec, Seifert (bib4) 2007; 5 Wróblewska, Towner, Marchel, Luczak (bib29) 2007; 13 Falagas, Thomaidis, Kotsantis, Sgouros, Samonis, Karageorgopoulos (bib7) 2011; 78 Sader, Farrell, Jones (bib27) 2011; 69 Clinical and Laboratory Standards Institute (bib11) 2011 AB bioMérieux Document 2009; 05, Solna. Dizbay, Altuncekic, Sezer, Ozdemir, Arman (bib22) 2008; 32 LaForgia, Franke, Hacek, Thomson, Robicsek, Peterson (bib6) 2010; 38 Boyce, Pittet (bib18) 2002; 23 Higgins, Wisplinghoff, Krut (bib9) 2007; 13 Higgins, Dammhayn, Hackel (bib15) 2010; 65 Falagas, Kopterides, Siempos (bib25) 2006; 43 Young, Sabel, Price (bib5) 2007; 28 Luna, Aruj (bib21) 2007; 2 Turton, Ward, Woodford (bib14) 2006; 258 Pachón, Vila (bib28) 2009; 10 Levin, Gobara, Mendes, Cursino, Sinto (bib1) 2001; 22 Van Looveren, Goossens (bib26) 2004; 10 Seifert, Dolzani, Bressan (bib16) 2005; 43 (bib17) 2008; 29 10.1016/j.jhin.2012.05.010_bib12 Woodford (10.1016/j.jhin.2012.05.010_bib13) 2006; 27 Sader (10.1016/j.jhin.2012.05.010_bib27) 2011; 69 Hardy (10.1016/j.jhin.2012.05.010_bib31) 2007; 66 Horan (10.1016/j.jhin.2012.05.010_bib8) 2008; 36 Falagas (10.1016/j.jhin.2012.05.010_bib7) 2011; 78 Peleg (10.1016/j.jhin.2012.05.010_bib2) 2008; 21 Sax (10.1016/j.jhin.2012.05.010_bib20) 2007; 67 Pachón (10.1016/j.jhin.2012.05.010_bib28) 2009; 10 Clinical and Laboratory Standards Institute (10.1016/j.jhin.2012.05.010_bib11) 2011 Markogiannakis (10.1016/j.jhin.2012.05.010_bib23) 2008; 29 Falagas (10.1016/j.jhin.2012.05.010_bib25) 2006; 43 Villegas (10.1016/j.jhin.2012.05.010_bib3) 2003; 24 Higgins (10.1016/j.jhin.2012.05.010_bib9) 2007; 13 Van Looveren (10.1016/j.jhin.2012.05.010_bib26) 2004; 10 Dijkshoorn (10.1016/j.jhin.2012.05.010_bib4) 2007; 5 Turton (10.1016/j.jhin.2012.05.010_bib14) 2006; 258 Valenzuela (10.1016/j.jhin.2012.05.010_bib30) 2007; 45 Higgins (10.1016/j.jhin.2012.05.010_bib15) 2010; 65 Luna (10.1016/j.jhin.2012.05.010_bib21) 2007; 2 Ray (10.1016/j.jhin.2012.05.010_bib32) 2010; 31 Siegel (10.1016/j.jhin.2012.05.010_bib19) 2007; 12 Levin (10.1016/j.jhin.2012.05.010_bib1) 2001; 22 Wróblewska (10.1016/j.jhin.2012.05.010_bib29) 2007; 13 Young (10.1016/j.jhin.2012.05.010_bib5) 2007; 28 LaForgia (10.1016/j.jhin.2012.05.010_bib6) 2010; 38 Seifert (10.1016/j.jhin.2012.05.010_bib16) 2005; 43 D'Arezzo (10.1016/j.jhin.2012.05.010_bib24) 2009; 15 (10.1016/j.jhin.2012.05.010_bib17) 2008; 29 Boyce (10.1016/j.jhin.2012.05.010_bib18) 2002; 23 Dizbay (10.1016/j.jhin.2012.05.010_bib22) 2008; 32 Leclercq (10.1016/j.jhin.2012.05.010_bib10) 2012 |
| References_xml | – volume: 12 start-page: S65 year: 2007 end-page: 164 ident: bib19 article-title: 2007 guideline for isolation precautions: preventing transmission of infectious agents in health care settings publication-title: Am J Infect Control contributor: fullname: Chiarello – volume: 69 start-page: 223 year: 2011 end-page: 227 ident: bib27 article-title: Tigecycline activity tested against multidrug-resistant Enterobacteriaceae and publication-title: Diagn Microbiol Infect Dis contributor: fullname: Jones – volume: 43 start-page: 389 year: 2006 ident: bib25 article-title: Attributable mortality of publication-title: Clin Infect Dis contributor: fullname: Siempos – volume: 38 start-page: 259 year: 2010 end-page: 263 ident: bib6 article-title: Management of a multidrug-resistant publication-title: Am J Infect Control contributor: fullname: Peterson – volume: 258 start-page: 72 year: 2006 end-page: 77 ident: bib14 article-title: The role of ISAba1 in expression of OXA carbapenemase genes in publication-title: FEMS Microbiol Lett contributor: fullname: Woodford – volume: 45 start-page: 453 year: 2007 end-page: 460 ident: bib30 article-title: Horizontal gene transfer in a polyclonal outbreak of carbapenem-resistant publication-title: J Clin Microbiol contributor: fullname: Iredell – year: 2011 ident: bib11 article-title: Performance standards for antimicrobial susceptibility testing. Twenty-first informational supplement. Document M100-S21 contributor: fullname: Clinical and Laboratory Standards Institute – volume: 24 start-page: 284 year: 2003 end-page: 295 ident: bib3 article-title: outbreaks 1977–2000 publication-title: Infect Control Hosp Epidemiol contributor: fullname: Hartstein – volume: 21 start-page: 538 year: 2008 end-page: 582 ident: bib2 article-title: : emergence of a successful pathogen publication-title: Clin Microbiol Rev contributor: fullname: Paterson – volume: 5 start-page: 939 year: 2007 end-page: 951 ident: bib4 article-title: An increasing threat in hospitals: multidrug-resistant publication-title: Nat Rev Microbiol contributor: fullname: Seifert – volume: 29 start-page: 410 year: 2008 end-page: 417 ident: bib23 article-title: Cross-transmission of multidrug-resistant publication-title: Infect Control Hosp Epidemiol contributor: fullname: Tsiplakou – volume: 43 start-page: 4328 year: 2005 end-page: 4335 ident: bib16 article-title: Standardization and interlaboratory reproducibility assessment of pulsed-field gel electrophoresis-generated fingerprints of publication-title: J Clin Microbiol contributor: fullname: Bressan – volume: 10 start-page: 150 year: 2009 end-page: 156 ident: bib28 article-title: Treatment of multiresistant publication-title: Curr Opin Investig Drugs contributor: fullname: Vila – volume: 36 start-page: 309 year: 2008 end-page: 332 ident: bib8 article-title: CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting publication-title: Am J Infect Control contributor: fullname: Dudeck – volume: 15 start-page: 347 year: 2009 end-page: 357 ident: bib24 article-title: Epidemic multidrug-resistant publication-title: Clin Microbiol Infect contributor: fullname: Petrosillo – volume: 22 start-page: 717 year: 2001 end-page: 720 ident: bib1 article-title: Environmental contamination by multidrug-resistant publication-title: Infect Control Hosp Epidemiol contributor: fullname: Sinto – volume: 65 start-page: 233 year: 2010 end-page: 238 ident: bib15 article-title: Global spread of carbapenem-resistant publication-title: J Antimicrob Chemother contributor: fullname: Hackel – volume: 13 start-page: 1199 year: 2007 end-page: 1201 ident: bib9 article-title: A PCR-based method to differentiate between publication-title: Clin Microbiol Infect contributor: fullname: Krut – volume: 78 start-page: 171 year: 2011 end-page: 177 ident: bib7 article-title: Airborne hydrogen peroxide for disinfection of the hospital environment and infection control: a systematic review publication-title: J Hosp Infect contributor: fullname: Karageorgopoulos – volume: 10 start-page: 684 year: 2004 end-page: 704 ident: bib26 article-title: Antimicrobial resistance of publication-title: Clin Microbiol Infect contributor: fullname: Goossens – volume: 27 start-page: 351 year: 2006 end-page: 353 ident: bib13 article-title: Multiplex PCR for genes encoding prevalent OXA carbapenemases in publication-title: Int J Antimicrob Agents contributor: fullname: Coelho – volume: 2 start-page: 787 year: 2007 end-page: 791 ident: bib21 article-title: Nosocomial publication-title: Respirology contributor: fullname: Aruj – year: 2012 ident: bib10 article-title: EUCAST expert rules in antimicrobial susceptibility testing publication-title: Clin Microbiol Infect contributor: fullname: Brown – volume: 31 start-page: 1236 year: 2010 end-page: 1241 ident: bib32 article-title: Use of vaporized hydrogen peroxide decontamination during an outbreak of multidrug-resistant publication-title: Infect Control Hosp Epidemiol contributor: fullname: Beltramini – volume: 13 start-page: 490 year: 2007 end-page: 496 ident: bib29 article-title: Emergence and spread of carbapenem-resistant strains of publication-title: Clin Microbiol Infect contributor: fullname: Luczak – volume: 67 start-page: 9 year: 2007 end-page: 21 ident: bib20 article-title: ‘My five moments for hand hygiene’: a user-centred design approach to understand, train, monitor and report hand hygiene publication-title: J Hosp Infect contributor: fullname: Pittet – volume: 23 start-page: S3 year: 2002 end-page: 40 ident: bib18 article-title: Healthcare Infection Control Practices Advisory Committee. Society for Healthcare Epidemiology of America. Association for Professionals in Infection Control. Infectious Diseases Society of America. Hand Hygiene Task Force: Guideline for hand hygiene in health-care settings: recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force publication-title: Infect Control Hosp Epidemiol contributor: fullname: Pittet – volume: 32 start-page: 29 year: 2008 end-page: 32 ident: bib22 article-title: Colistin and tigecycline susceptibility among multidrug-resistant publication-title: Int J Antimicrob Agents contributor: fullname: Arman – volume: 29 start-page: S31 year: 2008 end-page: S40 ident: bib17 article-title: SHEA/IDSA practice recommendation strategies to prevent ventilator-associated pneumonia in acute care hospitals publication-title: Infect Control Hosp Epidemiol – volume: 66 start-page: 360 year: 2007 end-page: 368 ident: bib31 article-title: Rapid recontamination with MRSA of the environment of an intensive care unit after decontamination with hydrogen peroxide vapour publication-title: J Hosp Infect contributor: fullname: Henderson – volume: 28 start-page: 1247 year: 2007 end-page: 1254 ident: bib5 article-title: Epidemiologic, clinical, and economic evaluation of an outbreak of clonal multidrug-resistant publication-title: Infect Control Hosp Epidemiol contributor: fullname: Price – volume: 65 start-page: 233 year: 2010 ident: 10.1016/j.jhin.2012.05.010_bib15 article-title: Global spread of carbapenem-resistant Acinetobacter baumannii publication-title: J Antimicrob Chemother doi: 10.1093/jac/dkp428 contributor: fullname: Higgins – volume: 5 start-page: 939 year: 2007 ident: 10.1016/j.jhin.2012.05.010_bib4 article-title: An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii publication-title: Nat Rev Microbiol doi: 10.1038/nrmicro1789 contributor: fullname: Dijkshoorn – volume: 78 start-page: 171 year: 2011 ident: 10.1016/j.jhin.2012.05.010_bib7 article-title: Airborne hydrogen peroxide for disinfection of the hospital environment and infection control: a systematic review publication-title: J Hosp Infect doi: 10.1016/j.jhin.2010.12.006 contributor: fullname: Falagas – volume: 21 start-page: 538 year: 2008 ident: 10.1016/j.jhin.2012.05.010_bib2 article-title: Acinetobacter baumannii: emergence of a successful pathogen publication-title: Clin Microbiol Rev doi: 10.1128/CMR.00058-07 contributor: fullname: Peleg – volume: 13 start-page: 490 year: 2007 ident: 10.1016/j.jhin.2012.05.010_bib29 article-title: Emergence and spread of carbapenem-resistant strains of Acinetobacter baumannii in a tertiary-care hospital in Poland publication-title: Clin Microbiol Infect doi: 10.1111/j.1469-0691.2007.01694.x contributor: fullname: Wróblewska – ident: 10.1016/j.jhin.2012.05.010_bib12 – volume: 24 start-page: 284 year: 2003 ident: 10.1016/j.jhin.2012.05.010_bib3 article-title: Acinetobacter outbreaks 1977–2000 publication-title: Infect Control Hosp Epidemiol doi: 10.1086/502205 contributor: fullname: Villegas – volume: 32 start-page: 29 year: 2008 ident: 10.1016/j.jhin.2012.05.010_bib22 article-title: Colistin and tigecycline susceptibility among multidrug-resistant Acinetobacter baumannii isolated from ventilator-associated pneumonia publication-title: Int J Antimicrob Agents doi: 10.1016/j.ijantimicag.2008.02.016 contributor: fullname: Dizbay – volume: 43 start-page: 4328 year: 2005 ident: 10.1016/j.jhin.2012.05.010_bib16 article-title: Standardization and interlaboratory reproducibility assessment of pulsed-field gel electrophoresis-generated fingerprints of Acinetobacter baumannii publication-title: J Clin Microbiol doi: 10.1128/JCM.43.9.4328-4335.2005 contributor: fullname: Seifert – volume: 29 start-page: 410 year: 2008 ident: 10.1016/j.jhin.2012.05.010_bib23 article-title: Cross-transmission of multidrug-resistant Acinetobacter baumannii clonal strains causing episodes of sepsis in a trauma intensive care unit publication-title: Infect Control Hosp Epidemiol doi: 10.1086/533545 contributor: fullname: Markogiannakis – volume: 13 start-page: 1199 year: 2007 ident: 10.1016/j.jhin.2012.05.010_bib9 article-title: A PCR-based method to differentiate between Acinetobacter baumannii and Acinetobacter genomic species 13TU publication-title: Clin Microbiol Infect doi: 10.1111/j.1469-0691.2007.01819.x contributor: fullname: Higgins – volume: 67 start-page: 9 year: 2007 ident: 10.1016/j.jhin.2012.05.010_bib20 article-title: ‘My five moments for hand hygiene’: a user-centred design approach to understand, train, monitor and report hand hygiene publication-title: J Hosp Infect doi: 10.1016/j.jhin.2007.06.004 contributor: fullname: Sax – year: 2012 ident: 10.1016/j.jhin.2012.05.010_bib10 article-title: EUCAST expert rules in antimicrobial susceptibility testing publication-title: Clin Microbiol Infect contributor: fullname: Leclercq – volume: 10 start-page: 150 year: 2009 ident: 10.1016/j.jhin.2012.05.010_bib28 article-title: Treatment of multiresistant Acinetobacter baumannii infections publication-title: Curr Opin Investig Drugs contributor: fullname: Pachón – volume: 27 start-page: 351 year: 2006 ident: 10.1016/j.jhin.2012.05.010_bib13 article-title: Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp publication-title: Int J Antimicrob Agents doi: 10.1016/j.ijantimicag.2006.01.004 contributor: fullname: Woodford – volume: 258 start-page: 72 year: 2006 ident: 10.1016/j.jhin.2012.05.010_bib14 article-title: The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii publication-title: FEMS Microbiol Lett doi: 10.1111/j.1574-6968.2006.00195.x contributor: fullname: Turton – volume: 45 start-page: 453 year: 2007 ident: 10.1016/j.jhin.2012.05.010_bib30 article-title: Horizontal gene transfer in a polyclonal outbreak of carbapenem-resistant Acinetobacter baumannii publication-title: J Clin Microbiol doi: 10.1128/JCM.01971-06 contributor: fullname: Valenzuela – volume: 12 start-page: S65 year: 2007 ident: 10.1016/j.jhin.2012.05.010_bib19 article-title: 2007 guideline for isolation precautions: preventing transmission of infectious agents in health care settings publication-title: Am J Infect Control doi: 10.1016/j.ajic.2007.10.007 contributor: fullname: Siegel – year: 2011 ident: 10.1016/j.jhin.2012.05.010_bib11 contributor: fullname: Clinical and Laboratory Standards Institute – volume: 15 start-page: 347 year: 2009 ident: 10.1016/j.jhin.2012.05.010_bib24 article-title: Epidemic multidrug-resistant Acinetobacter baumannii related to European clonal types I and II in Rome (Italy) publication-title: Clin Microbiol Infect doi: 10.1111/j.1469-0691.2009.02668.x contributor: fullname: D'Arezzo – volume: 23 start-page: S3 issue: 12 Suppl. year: 2002 ident: 10.1016/j.jhin.2012.05.010_bib18 publication-title: Infect Control Hosp Epidemiol doi: 10.1086/503164 contributor: fullname: Boyce – volume: 66 start-page: 360 year: 2007 ident: 10.1016/j.jhin.2012.05.010_bib31 article-title: Rapid recontamination with MRSA of the environment of an intensive care unit after decontamination with hydrogen peroxide vapour publication-title: J Hosp Infect doi: 10.1016/j.jhin.2007.05.009 contributor: fullname: Hardy – volume: 69 start-page: 223 year: 2011 ident: 10.1016/j.jhin.2012.05.010_bib27 article-title: Tigecycline activity tested against multidrug-resistant Enterobacteriaceae and Acinetobacter spp. isolated in US medical centers (2005–2009) publication-title: Diagn Microbiol Infect Dis doi: 10.1016/j.diagmicrobio.2010.10.020 contributor: fullname: Sader – volume: 43 start-page: 389 year: 2006 ident: 10.1016/j.jhin.2012.05.010_bib25 article-title: Attributable mortality of Acinetobacter baumannii infection among critically ill patients publication-title: Clin Infect Dis doi: 10.1086/505599 contributor: fullname: Falagas – volume: 29 start-page: S31 year: 2008 ident: 10.1016/j.jhin.2012.05.010_bib17 article-title: SHEA/IDSA practice recommendation strategies to prevent ventilator-associated pneumonia in acute care hospitals publication-title: Infect Control Hosp Epidemiol doi: 10.1086/591062 – volume: 10 start-page: 684 year: 2004 ident: 10.1016/j.jhin.2012.05.010_bib26 article-title: Antimicrobial resistance of Acinetobacter spp. in Europe publication-title: Clin Microbiol Infect doi: 10.1111/j.1469-0691.2004.00942.x contributor: fullname: Van Looveren – volume: 38 start-page: 259 year: 2010 ident: 10.1016/j.jhin.2012.05.010_bib6 article-title: Management of a multidrug-resistant Acinetobacter baumannii outbreak in an intensive care unit using novel environmental disinfection: a 38-month report publication-title: Am J Infect Control doi: 10.1016/j.ajic.2009.07.012 contributor: fullname: LaForgia – volume: 31 start-page: 1236 year: 2010 ident: 10.1016/j.jhin.2012.05.010_bib32 article-title: Use of vaporized hydrogen peroxide decontamination during an outbreak of multidrug-resistant Acinetobacter baumannii infection at a long-term acute care hospital publication-title: Infect Control Hosp Epidemiol doi: 10.1086/657139 contributor: fullname: Ray – volume: 22 start-page: 717 year: 2001 ident: 10.1016/j.jhin.2012.05.010_bib1 article-title: Environmental contamination by multidrug-resistant Acinetobacter baumannii in an intensive care unit publication-title: Infect Control Hosp Epidemiol doi: 10.1086/501852 contributor: fullname: Levin – volume: 28 start-page: 1247 year: 2007 ident: 10.1016/j.jhin.2012.05.010_bib5 article-title: Epidemiologic, clinical, and economic evaluation of an outbreak of clonal multidrug-resistant Acinetobacter baumannii infection in a surgical intensive care unit publication-title: Infect Control Hosp Epidemiol doi: 10.1086/521660 contributor: fullname: Young – volume: 36 start-page: 309 year: 2008 ident: 10.1016/j.jhin.2012.05.010_bib8 article-title: CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting publication-title: Am J Infect Control doi: 10.1016/j.ajic.2008.03.002 contributor: fullname: Horan – volume: 2 start-page: 787 year: 2007 ident: 10.1016/j.jhin.2012.05.010_bib21 article-title: Nosocomial Acinetobacter pneumonia publication-title: Respirology doi: 10.1111/j.1440-1843.2007.01147.x contributor: fullname: Luna |
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| Snippet | Summary Background Multidrug-resistant Acinetobacter baumannii (MRAB) is a serious nosocomial pathogen characterized by its survival on inanimate surfaces for... Multidrug-resistant Acinetobacter baumannii (MRAB) is a serious nosocomial pathogen characterized by its survival on inanimate surfaces for long periods,... BACKGROUNDMultidrug-resistant Acinetobacter baumannii (MRAB) is a serious nosocomial pathogen characterized by its survival on inanimate surfaces for long... |
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| SubjectTerms | Acinetobacter baumannii - classification Acinetobacter baumannii - drug effects Acinetobacter baumannii - genetics Acinetobacter baumannii - isolation & purification Acinetobacter Infections - epidemiology Acinetobacter Infections - microbiology Acinetobacter Infections - prevention & control Aged Anti-Bacterial Agents - pharmacology Carbapenems - pharmacology Cross Infection - epidemiology Cross Infection - microbiology Cross Infection - prevention & control Disease Outbreaks Disinfectants - pharmacology Disinfection - methods Electrophoresis, Gel, Pulsed-Field Hospital-acquired infection Humans Hydrogen Peroxide - pharmacology Infectious Disease Intensive Care Units Male Microbial Sensitivity Tests Molecular Typing Multidrug-resistant Acinetobacter baumannii Outbreak Vaporized hydrogen peroxide Volatilization |
| Title | Control of an outbreak of Acinetobacter baumannii infections using vaporized hydrogen peroxide |
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