Reference Ranges of Fetal Cardiac Biometric Parameters Using Three-Dimensional Ultrasound with Spatiotemporal Image Correlation M Mode and Their Applicability in Congenital Heart Diseases

• Published in: Pediatric cardiology Vol. 38; no. 2; pp. 271 - 279
• Main Authors: Tedesco, Giselle Darahem, de Souza Bezerra, Marilim, Barros, Fernanda Silveira Bello, Martins, Wellington P., Nardozza, Luciano Marcondes Machado, Carrilho, Milene Carvalho, Moron, Antonio Fernandes, Carvalho, Francisco Herlânio Costa, Rolo, Liliam Cristine, Araujo Júnior, Edward
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-02-2017; Springer
• Subjects: Adolescent; Adult; Brazil; Cardiac Surgery; Cardiology; Congenital heart disease; Cross-Sectional Studies; Echocardiography, Three-Dimensional; Female; Fetal Heart - diagnostic imaging; Gestational Age; Heart Defects, Congenital - diagnostic imaging; Heart diseases; Heart Ventricles - diagnostic imaging; Humans; Medicine; Medicine & Public Health; Middle Aged; Original Article; Pregnancy; Prospective Studies; Reference Values; Regression Analysis; Reproducibility of Results; Ultrasonography, Prenatal; Vascular Surgery; Ventricular Septum - diagnostic imaging; Young Adult; Interventricular septum; Congenital heart disease; Spatiotemporal image correlation; Reference ranges; Fetal heart; Three-dimensional ultrasound
• ISSN: 0172-0643; 1432-1971
• DOI: 10.1007/s00246-016-1509-1

To determine reference values for fetal heart biometric parameters using the spatiotemporal image correlation (STIC) M mode and their applicability in congenital heart diseases (CHDs). A cross-sectional prospective study was conducted with 300 singleton pregnancies between 20 and 33 + 6 weeks of gestation. Right ventricular wall thickness (RVWT), interventricular septum thickness (IVST), and left ventricular wall thickness (LVWT) were measured off-line using the STIC-M mode with the cursor perpendicular to the interventricular septum. Polynomial regressions adjusted with the coefficient of determination (
R
2
) were performed. The curves were applied to 14 fetuses with structural CHD. For the reproducibility calculations, the concordance correlation coefficient (CCC) was used. The mean RVWT, IVST, and LVWT were 0.34 ± 0.09 cm, 0.28 ± 0.09 cm, and 0.30 ± 0.07 cm, respectively. There was correlation between RVWT, IVST, and LVWT and gestational age (GA): RVWT = −0.002 + 0.013 × GA (
R
2
 = 0.33), IVST = −0.011 + 0.011 × GA (
R
2
 = 0.25), and LVWT = 0.056 + 0.009 × GA (
R
2
 = 0.26). RVWT, IVST, and LVWT were altered (<5th or >95th percentile) in 5/14, 5/14, and 7/14 of the fetuses with CHD, respectively. For RVWT, IVST, and LVWT, intra-observer (CCC = 0.86, 0.85, and 0.87, respectively) and inter-observer (CCC = 0.86, 0.86, and 0.86, respectively) reproducibility were good/moderate. The reference ranges determined for fetal heart biometric parameters using STIC-M had good intra- and inter-observer reproducibility and were applicable to fetuses with CHD.