Synthesis and transfection activity of novel galactosylated polycationic lipid

In this study, we synthesized a new galactosylated cationic lipid and investigated its biological activity. The structure of lipid combines both spermine residue for DNA compaction and galactose moiety for the improvement of aggregation behavior of lipoplexes. Lipid was low toxic for different mamma...

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Bibliographic Details
Published in:	Bioorganic & medicinal chemistry letters Vol. 21; no. 10; pp. 2937 - 2940
Main Authors:	Maslov, M.A., Medvedeva, D.A., Rapoport, D.A., Serikov, R.N., Morozova, N.G., Serebrennikova, G.A., Vlassov, V.V., Zenkova, М.A.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 15-05-2011
Subjects:	Aggregation behavior Animals Cationic lipids Cell Line Cell Survival - drug effects Compaction Cricetinae DNA EGFP expression Flow Cytometry Galactose Galactose - chemistry gene expression Gene silencing Gene Transfer Techniques Humans Lipids Lipids - chemical synthesis Lipids - chemistry Lipids - toxicity Liposomes - chemistry Mammalian cells mammals Microscopy, Atomic Force Molecular Structure nucleic acids Oligonucleotides Plasmids Polyamines - chemistry siRNA small interfering RNA Spermine toxicity Transfection Transfection efficiency Transgenes siRNA EGFP expression Transfection efficiency Cationic lipids Oligonucleotides
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