Counterpoint: The evidence does not support universal screening and treatment in children
Abstract Few pediatric guidelines have generated the amount or intensity of controversy that the pediatric lipid guidelines have. In the following article, I will synthesize the arguments against universal lipid screening and treatment in childhood. Direct evidence that relates the presence of cardi...
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| Published in: | Journal of clinical lipidology Vol. 9; no. 5; pp. S101 - S106 |
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| Abstract | Abstract Few pediatric guidelines have generated the amount or intensity of controversy that the pediatric lipid guidelines have. In the following article, I will synthesize the arguments against universal lipid screening and treatment in childhood. Direct evidence that relates the presence of cardiovascular risk factors in childhood to cardiovascular disease outcomes in adulthood is unavailable, and as a consequence, the guidelines were formulated based on a chain of indirect evidence. The debate centers on the strength of the indirect evidence that links risk factors present in childhood to adult disease outcomes. The arguments against universal lipid screening and treatment of children include (1) a history of unanticipated harms caused by screening tests or treatments that were enacted based on indirect evidence, (2) the poor test performance characteristics of lipid profiles in childhood when used as a screening test, (3) problems with the effectiveness of lipid testing done in the office setting, and (4) concerns regarding the safety of statins when used in children. |
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| AbstractList | Few pediatric guidelines have generated the amount or intensity of controversy that the pediatric lipid guidelines have. In the following article, I will synthesize the arguments against universal lipid screening and treatment in childhood. Direct evidence that relates the presence of cardiovascular risk factors in childhood to cardiovascular disease outcomes in adulthood is unavailable, and as a consequence, the guidelines were formulated based on a chain of indirect evidence. The debate centers on the strength of the indirect evidence that links risk factors present in childhood to adult disease outcomes. The arguments against universal lipid screening and treatment of children include (1) a history of unanticipated harms caused by screening tests or treatments that were enacted based on indirect evidence, (2) the poor test performance characteristics of lipid profiles in childhood when used as a screening test, (3) problems with the effectiveness of lipid testing done in the office setting, and (4) concerns regarding the safety of statins when used in children. Abstract Few pediatric guidelines have generated the amount or intensity of controversy that the pediatric lipid guidelines have. In the following article, I will synthesize the arguments against universal lipid screening and treatment in childhood. Direct evidence that relates the presence of cardiovascular risk factors in childhood to cardiovascular disease outcomes in adulthood is unavailable, and as a consequence, the guidelines were formulated based on a chain of indirect evidence. The debate centers on the strength of the indirect evidence that links risk factors present in childhood to adult disease outcomes. The arguments against universal lipid screening and treatment of children include (1) a history of unanticipated harms caused by screening tests or treatments that were enacted based on indirect evidence, (2) the poor test performance characteristics of lipid profiles in childhood when used as a screening test, (3) problems with the effectiveness of lipid testing done in the office setting, and (4) concerns regarding the safety of statins when used in children. Few pediatric guidelines have generated the amount or intensity of controversy that the pediatric lipid guidelines have. In the following article, I will synthesize the arguments against universal lipid screening and treatment in childhood. Direct evidence that relates the presence of cardiovascular risk factors in childhood to cardiovascular disease outcomes in adulthood is unavailable, and as a consequence, the guidelines were formulated based on a chain of indirect evidence. The debate centers on the strength of the indirect evidence that links risk factors present in childhood to adult disease outcomes. The arguments against universal lipid screening and treatment of children include (1) a history of unanticipated harms caused by screening tests or treatments that were enacted based on indirect evidence, (2) the poor test performance characteristics of lipid profiles in childhood when used as a screening test, (3) problems with the effectiveness of lipid testing done in the office setting, and (4) concerns regarding the safety of statins when used in children. •The lipid screening guidelines have generated a significant amount of controversy.•Some screening programs enacted in the absence of direct outcome data have caused harm.•Lipid abnormalities defined by statistical cut points do not track well into adulthood.•The effectiveness of lipid screening is unproven and its uptake by pediatricians is low.•Statins use is associated with a risk of incident diabetes. |
| Author | Belamarich, Peter F., MD |
| Author_xml | – sequence: 1 fullname: Belamarich, Peter F., MD |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26343207$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_pedn_2022_07_007 crossref_primary_10_1016_j_acap_2017_02_006 crossref_primary_10_1016_j_jacl_2017_07_002 crossref_primary_10_1080_13102818_2017_1376596 crossref_primary_10_1111_fcp_12542 |
| Cites_doi | 10.1016/S0140-6736(06)68170-1 10.14423/SMJ.0000000000000219 10.1016/j.bone.2013.01.044 10.1542/peds.2005-2968 10.1016/j.acap.2010.12.008 10.1001/jama.288.3.321 10.1161/CIRCULATIONAHA.108.816769 10.1002/art.30645 10.1542/peds.2006-0652 10.1016/j.jacc.2009.10.042 10.1056/NEJMoa012277 10.1001/archpediatrics.2010.299 10.1542/peds.99.5.e5 10.1016/j.jacc.2013.11.002 10.1001/jamapediatrics.2015.0168 10.1056/NEJMsa073166 10.1001/jama.2014.8892 10.1016/j.jacl.2014.01.002 10.2337/dc09-0738 10.3899/jrheum.120110 10.1542/peds.2011-2726 10.1038/nature13775 10.1001/jama.2014.2410 10.1016/j.amjcard.2005.12.010 10.1001/jama.1996.03530340032026 10.1093/oxfordjournals.aje.a113490 10.1542/peds.2006-0787 10.1016/j.mehy.2008.10.039 10.1093/qjmed/hcq165 10.1016/S0165-6147(97)01147-4 10.1001/jama.1995.03520420045036 10.1056/NEJMp1409841 10.1161/ATVBAHA.107.145151 10.1016/j.ahj.2014.12.018 10.1001/jama.2011.2012 10.1001/archpediatrics.2009.152 10.1002/clc.22075 10.1001/archinternmed.2010.48 10.1542/peds.89.6.1159 10.1093/clinchem/42.5.732 10.1542/peds.98.3.383 10.1016/j.pharmthera.2014.02.007 10.1016/j.jpeds.2013.10.027 10.1542/peds.2006-1812 10.1200/JCO.1998.16.4.1265 10.1542/peds.2012-0481 10.1016/j.cjca.2014.12.017 10.1001/jama.2011.1916 |
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| Keywords | Overdiagnosis Cardiovascular risk Lipid screening Controversy Statin Children Guidelines |
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| References | Avis, Hutten, Gagne (bib34) 2010; 55 2012. Available at Law, Rudnicka (bib25) 2006; 97 Nader, Yang, Luepker (bib20) 1997; 99 Vinci, Rifas-Shiman, Cheng, Mannix, Gillman, de Ferranti (bib44) 2014; 311 Dixon, Kornblum, Steffen, Zhou, Steinberger (bib45) 2014; 164 Jacobs, Barrett-Connor (bib23) 1982; 116 Mills, Wu, Chong (bib27) 2011; 104 Liu, Zhu, Yang, Huang, Ye (bib42) 2013; 54 Friedman, Morrison, Daniels, McCarthy, Sprecher (bib11) 2006; 118 (bib10) 2007; 120 Kusters, Avis, de Groot (bib36) 2014; 312 Doshi, Perrin, Lazorick, Esserman, Steiner (bib18) 2009; 163 Schectman, Patsches, Sasse (bib24) 1996; 42 Schroeder, Redberg (bib14) 2012; 35 Rajpathak, Kumbhani, Crandall, Barzilai, Alderman, Ridker (bib29) 2009; 32 Schroeder, Harris, Newman (bib9) 2011; 128 Yamamoto, Hanada, Kikuchi (bib2) 1998; 16 Bibbins-Domingo, Coxson, Pletcher, Lightwood, Goldman (bib16) 2007; 357 Poirier, McCrindle, Leiter (bib17) 2015; 31 Ahn, Kim, Welch (bib4) 2014; 371 Beukelman, Ringold, Davis (bib53) 2012; 39 Belamarich, Gandica, Stein, Racine (bib46) 2006; 118 (bib12) 2011; 128 Newman, Pletcher, Hulley (bib38) 2012; 130 Csoka, Szyf (bib43) 2009; 73 Gooding, Rodday, Wong (bib7) 2015; 169 Vuorio, Kuoppala, Kovanen (bib33) 2014; 7 Ford, Li, Zhao, Mokdad (bib49) 2009; 119 Yamashita, Morioka, Kishi (bib41) 2014; 513 Yeboah, Sillau, Delaney (bib31) 2015; 169 Lannon, Earp (bib21) 1992; 89 Hamelin, Turgeon (bib39) 1998; 19 Wilkinson, Page, Uribe, Espinosa, Cabral (bib52) 2007; 34 Redberg (bib8) 2010; 170 LeFevre, Moyer (bib3) 2013; 27 Norlin, Crawford, Bell, Sheng, Stein (bib47) 2011; 11 Watts, Gidding, Wierzbicki (bib51) 2014; 8 Schilling, Spix, Berthold (bib1) 2002; 346 Belay, Belamarich, Tom-Revzon (bib37) 2007; 119 Accessed May 19, 2015. Rossouw, Anderson, Prentice (bib5) 2002; 288 (bib22) 1995; 273 Yeganeh, Wiechec, Ande (bib40) 2014; 143 Wilson, McNeal, Blackett (bib50) 2015; 108 Psaty, Rivara (bib28) 2012; 307 Schanberg, Sandborg, Barnhart (bib35) 2012; 64 Rifai, Neufeld, Ahlstrom, Rimm, D'Angelo, Hicks (bib13) 1996; 98 Stone, Robinson, Lichtenstein (bib6) 2014; 63 Grossman, Moyer, Melnyk, Chou, DeWitt (bib48) 2011; 165 Avis, Vissers, Stein (bib32) 2007; 27 Gillman, Daniels (bib15) 2012; 307 Luepker, Perry, McKinlay (bib19) 1996; 275 Law, Wald (bib26) 2006; 367 LeFevre (10.1016/j.jacl.2015.07.001_bib3) 2013; 27 Schilling (10.1016/j.jacl.2015.07.001_bib1) 2002; 346 Belay (10.1016/j.jacl.2015.07.001_bib37) 2007; 119 Yeganeh (10.1016/j.jacl.2015.07.001_bib40) 2014; 143 10.1016/j.jacl.2015.07.001_bib30 Law (10.1016/j.jacl.2015.07.001_bib25) 2006; 97 Wilkinson (10.1016/j.jacl.2015.07.001_bib52) 2007; 34 Beukelman (10.1016/j.jacl.2015.07.001_bib53) 2012; 39 Yamamoto (10.1016/j.jacl.2015.07.001_bib2) 1998; 16 Gillman (10.1016/j.jacl.2015.07.001_bib15) 2012; 307 Friedman (10.1016/j.jacl.2015.07.001_bib11) 2006; 118 Gooding (10.1016/j.jacl.2015.07.001_bib7) 2015; 169 Schroeder (10.1016/j.jacl.2015.07.001_bib9) 2011; 128 Redberg (10.1016/j.jacl.2015.07.001_bib8) 2010; 170 Schroeder (10.1016/j.jacl.2015.07.001_bib14) 2012; 35 Belamarich (10.1016/j.jacl.2015.07.001_bib46) 2006; 118 Jacobs (10.1016/j.jacl.2015.07.001_bib23) 1982; 116 (10.1016/j.jacl.2015.07.001_bib12) 2011; 128 Lannon (10.1016/j.jacl.2015.07.001_bib21) 1992; 89 Vinci (10.1016/j.jacl.2015.07.001_bib44) 2014; 311 Mills (10.1016/j.jacl.2015.07.001_bib27) 2011; 104 Vuorio (10.1016/j.jacl.2015.07.001_bib33) 2014; 7 Dixon (10.1016/j.jacl.2015.07.001_bib45) 2014; 164 Grossman (10.1016/j.jacl.2015.07.001_bib48) 2011; 165 Schectman (10.1016/j.jacl.2015.07.001_bib24) 1996; 42 Norlin (10.1016/j.jacl.2015.07.001_bib47) 2011; 11 Watts (10.1016/j.jacl.2015.07.001_bib51) 2014; 8 Nader (10.1016/j.jacl.2015.07.001_bib20) 1997; 99 Rifai (10.1016/j.jacl.2015.07.001_bib13) 1996; 98 Psaty (10.1016/j.jacl.2015.07.001_bib28) 2012; 307 Avis (10.1016/j.jacl.2015.07.001_bib34) 2010; 55 Wilson (10.1016/j.jacl.2015.07.001_bib50) 2015; 108 Doshi (10.1016/j.jacl.2015.07.001_bib18) 2009; 163 Hamelin (10.1016/j.jacl.2015.07.001_bib39) 1998; 19 Yamashita (10.1016/j.jacl.2015.07.001_bib41) 2014; 513 (10.1016/j.jacl.2015.07.001_bib22) 1995; 273 (10.1016/j.jacl.2015.07.001_bib10) 2007; 120 Avis (10.1016/j.jacl.2015.07.001_bib32) 2007; 27 Rossouw (10.1016/j.jacl.2015.07.001_bib5) 2002; 288 Newman (10.1016/j.jacl.2015.07.001_bib38) 2012; 130 Stone (10.1016/j.jacl.2015.07.001_bib6) 2014; 63 Ford (10.1016/j.jacl.2015.07.001_bib49) 2009; 119 Ahn (10.1016/j.jacl.2015.07.001_bib4) 2014; 371 Poirier (10.1016/j.jacl.2015.07.001_bib17) 2015; 31 Luepker (10.1016/j.jacl.2015.07.001_bib19) 1996; 275 Yeboah (10.1016/j.jacl.2015.07.001_bib31) 2015; 169 Schanberg (10.1016/j.jacl.2015.07.001_bib35) 2012; 64 Liu (10.1016/j.jacl.2015.07.001_bib42) 2013; 54 Csoka (10.1016/j.jacl.2015.07.001_bib43) 2009; 73 Law (10.1016/j.jacl.2015.07.001_bib26) 2006; 367 Bibbins-Domingo (10.1016/j.jacl.2015.07.001_bib16) 2007; 357 Rajpathak (10.1016/j.jacl.2015.07.001_bib29) 2009; 32 Kusters (10.1016/j.jacl.2015.07.001_bib36) 2014; 312 |
| References_xml | – volume: 32 start-page: 1924 year: 2009 end-page: 1929 ident: bib29 article-title: Statin therapy and risk of developing type 2 diabetes: a meta-analysis publication-title: Diabetes Care contributor: fullname: Ridker – volume: 35 start-page: 665 year: 2012 end-page: 668 ident: bib14 article-title: Cholesterol screening and management in children and young adults should start early–NO! publication-title: Clin Cardiol contributor: fullname: Redberg – volume: 64 start-page: 285 year: 2012 end-page: 296 ident: bib35 article-title: Use of atorvastatin in systemic lupus erythematosus in children and adolescents publication-title: Arthritis Rheum contributor: fullname: Barnhart – volume: 165 start-page: 205 year: 2011 end-page: 210 ident: bib48 article-title: The anatomy of a US Preventive Services Task Force Recommendation: lipid screening for children and adolescents publication-title: Arch Pediatr Adolesc Med contributor: fullname: DeWitt – volume: 367 start-page: 469 year: 2006 end-page: 470 ident: bib26 article-title: Efficacy and safety of cholesterol-lowering treatment publication-title: Lancet contributor: fullname: Wald – volume: 73 start-page: 770 year: 2009 end-page: 780 ident: bib43 article-title: Epigenetic side-effects of common pharmaceuticals: a potential new field in medicine and pharmacology publication-title: Med Hypotheses contributor: fullname: Szyf – volume: 130 start-page: 349 year: 2012 end-page: 352 ident: bib38 article-title: Overly aggressive new guidelines for lipid screening in children: evidence of a broken process publication-title: Pediatrics contributor: fullname: Hulley – volume: 11 start-page: 18 year: 2011 end-page: 26 ident: bib47 article-title: Delivery of well-child care: a look inside the door publication-title: Acad Pediatr contributor: fullname: Stein – volume: 120 start-page: e215 year: 2007 end-page: e219 ident: bib10 article-title: Screening for lipid disorders in children: US Preventive Services Task Force recommendation statement publication-title: Pediatrics – volume: 108 start-page: 7 year: 2015 end-page: 14 ident: bib50 article-title: Pediatric dyslipidemia: recommendations for clinical management publication-title: South Med J contributor: fullname: Blackett – volume: 55 start-page: 1121 year: 2010 end-page: 1126 ident: bib34 article-title: Efficacy and safety of rosuvastatin therapy for children with familial hypercholesterolemia publication-title: J Am Coll Cardiol contributor: fullname: Gagne – volume: 27 start-page: 981 year: 2013 end-page: 982 ident: bib3 article-title: PSA screening: good evidence shows little benefit, significant harms publication-title: Oncology (Williston Park) contributor: fullname: Moyer – volume: 128 start-page: S213 year: 2011 end-page: S256 ident: bib12 article-title: Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: summary report publication-title: Pediatrics – volume: 104 start-page: 109 year: 2011 end-page: 124 ident: bib27 article-title: Efficacy and safety of statin treatment for cardiovascular disease: a network meta-analysis of 170,255 patients from 76 randomized trials publication-title: QJM contributor: fullname: Chong – volume: 16 start-page: 1265 year: 1998 end-page: 1269 ident: bib2 article-title: Spontaneous regression of localized neuroblastoma detected by mass screening publication-title: J Clin Oncol contributor: fullname: Kikuchi – volume: 99 start-page: E5 year: 1997 ident: bib20 article-title: Parent and physician response to children's cholesterol values of 200 mg/dL or greater: the Child and Adolescent Trial for Cardiovascular Health Experiment publication-title: Pediatrics contributor: fullname: Luepker – volume: 119 start-page: 1108 year: 2009 end-page: 1115 ident: bib49 article-title: Concentrations of low-density lipoprotein cholesterol and total cholesterol among children and adolescents in the United States publication-title: Circulation contributor: fullname: Mokdad – volume: 97 start-page: 52C year: 2006 end-page: 60C ident: bib25 article-title: Statin safety: a systematic review publication-title: Am J Cardiol contributor: fullname: Rudnicka – volume: 170 start-page: 584 year: 2010 ident: bib8 article-title: Less is more publication-title: Arch Intern Med contributor: fullname: Redberg – volume: 119 start-page: 370 year: 2007 end-page: 380 ident: bib37 article-title: The use of statins in pediatrics: knowledge base, limitations, and future directions publication-title: Pediatrics contributor: fullname: Tom-Revzon – volume: 34 start-page: 224 year: 2007 end-page: 226 ident: bib52 article-title: Establishment of a pilot pediatric registry for chronic vasculitis is both essential and feasible: a Childhood Arthritis and Rheumatology Alliance (CARRA) survey publication-title: J Rheumatol contributor: fullname: Cabral – volume: 307 start-page: 259 year: 2012 end-page: 260 ident: bib15 article-title: Is universal pediatric lipid screening justified? publication-title: JAMA contributor: fullname: Daniels – volume: 42 start-page: 732 year: 1996 end-page: 737 ident: bib24 article-title: Variability in cholesterol measurements: comparison of calculated and direct LDL cholesterol determinations publication-title: Clin Chem contributor: fullname: Sasse – volume: 357 start-page: 2371 year: 2007 end-page: 2379 ident: bib16 article-title: Adolescent overweight and future adult coronary heart disease publication-title: N Engl J Med contributor: fullname: Goldman – volume: 371 start-page: 1765 year: 2014 end-page: 1767 ident: bib4 article-title: Korea's thyroid-cancer “epidemic”–screening and overdiagnosis publication-title: N Engl J Med contributor: fullname: Welch – volume: 19 start-page: 26 year: 1998 end-page: 37 ident: bib39 article-title: Hydrophilicity/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors publication-title: Trends Pharmacol Sci contributor: fullname: Turgeon – volume: 128 start-page: e1596 year: 2011 end-page: e1597 ident: bib9 article-title: Safely doing less: a missing component of the patient safety dialogue publication-title: Pediatrics contributor: fullname: Newman – volume: 89 start-page: 1159 year: 1992 end-page: 1163 ident: bib21 article-title: Parents' behavior and attitudes toward screening children for high serum cholesterol levels publication-title: Pediatrics contributor: fullname: Earp – volume: 118 start-page: 165 year: 2006 end-page: 172 ident: bib11 article-title: Sensitivity and specificity of pediatric lipid determinations for adult lipid status: findings from the Princeton Lipid Research Clinics Prevalence Program Follow-up Study publication-title: Pediatrics contributor: fullname: Sprecher – volume: 169 start-page: 569 year: 2015 end-page: 574 ident: bib7 article-title: Application of pediatric and adult guidelines for treatment of lipid levels among US adolescents transitioning to young adulthood publication-title: JAMA Pediatr contributor: fullname: Wong – volume: 346 start-page: 1047 year: 2002 end-page: 1053 ident: bib1 article-title: Neuroblastoma screening at one year of age publication-title: N Engl J Med contributor: fullname: Berthold – volume: 98 start-page: 383 year: 1996 end-page: 388 ident: bib13 article-title: Failure of current guidelines for cholesterol screening in urban African-American adolescents publication-title: Pediatrics contributor: fullname: Hicks – volume: 169 start-page: 387 year: 2015 end-page: 395.e3 ident: bib31 article-title: Implications of the new American College of Cardiology/American Heart Association cholesterol guidelines for primary atherosclerotic cardiovascular disease event prevention in a multi ethnic cohort: Multi-Ethnic Study of Atherosclerosis (MESA) publication-title: Am Heart J contributor: fullname: Delaney – volume: 54 start-page: 151 year: 2013 end-page: 156 ident: bib42 article-title: HMG-CoA reductase inhibitors (statins) and bone mineral density: a meta-analysis publication-title: Bone contributor: fullname: Ye – volume: 116 start-page: 878 year: 1982 end-page: 885 ident: bib23 article-title: Retest reliability of plasma cholesterol and triglyceride. The Lipid Research Clinics Prevalence Study publication-title: Am J Epidemiol contributor: fullname: Barrett-Connor – volume: 513 start-page: 507 year: 2014 end-page: 511 ident: bib41 article-title: Statin treatment rescues FGFR3 skeletal dysplasia phenotypes publication-title: Nature contributor: fullname: Kishi – volume: 118 start-page: e964 year: 2006 end-page: e978 ident: bib46 article-title: Drowning in a sea of advice: pediatricians and American Academy of Pediatrics policy statements publication-title: Pediatrics contributor: fullname: Racine – volume: 275 start-page: 768 year: 1996 end-page: 776 ident: bib19 article-title: Outcomes of a field trial to improve children's dietary patterns and physical activity. The Child and Adolescent Trial for Cardiovascular Health. CATCH collaborative group publication-title: JAMA contributor: fullname: McKinlay – volume: 273 start-page: 1429 year: 1995 end-page: 1435 ident: bib22 article-title: Efficacy and safety of lowering dietary intake of fat and cholesterol in children with elevated low-density lipoprotein cholesterol. The Dietary Intervention Study in Children (DISC). The Writing Group for the DISC Collaborative Research Group publication-title: JAMA – volume: 288 start-page: 321 year: 2002 end-page: 333 ident: bib5 article-title: Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial publication-title: JAMA contributor: fullname: Prentice – volume: 63 start-page: 2889 year: 2014 end-page: 2934 ident: bib6 article-title: 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines publication-title: J Am Coll Cardiol contributor: fullname: Lichtenstein – volume: 143 start-page: 87 year: 2014 end-page: 110 ident: bib40 article-title: Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease publication-title: Pharmacol Ther contributor: fullname: Ande – volume: 312 start-page: 1055 year: 2014 end-page: 1057 ident: bib36 article-title: Ten-year follow-up after initiation of statin therapy in children with familial hypercholesterolemia publication-title: JAMA contributor: fullname: de Groot – volume: 164 start-page: 572 year: 2014 end-page: 576 ident: bib45 article-title: Implementation of lipid screening guidelines in children by primary pediatric providers publication-title: J Pediatr contributor: fullname: Steinberger – volume: 163 start-page: 812 year: 2009 end-page: 817 ident: bib18 article-title: Short-term change in body mass index in overweight adolescents following cholesterol screening publication-title: Arch Pediatr Adolesc Med contributor: fullname: Steiner – volume: 311 start-page: 1804 year: 2014 end-page: 1807 ident: bib44 article-title: Cholesterol testing among children and adolescents during health visits publication-title: JAMA contributor: fullname: de Ferranti – volume: 27 start-page: 1803 year: 2007 end-page: 1810 ident: bib32 article-title: A systematic review and meta-analysis of statin therapy in children with familial hypercholesterolemia publication-title: Arterioscler Thromb Vasc Biol contributor: fullname: Stein – volume: 8 start-page: 148 year: 2014 end-page: 172 ident: bib51 article-title: Integrated guidance on the care of familial hypercholesterolemia from the International FH Foundation publication-title: J Clin Lipidol contributor: fullname: Wierzbicki – volume: 31 start-page: 105 year: 2015 end-page: 108 ident: bib17 article-title: Obesity-it must not remain the neglected risk factor in cardiology publication-title: Can J Cardiol contributor: fullname: Leiter – volume: 39 start-page: 1867 year: 2012 end-page: 1874 ident: bib53 article-title: Disease-modifying antirheumatic drug use in the treatment of juvenile idiopathic arthritis: a cross-sectional analysis of the CARRA Registry publication-title: J Rheumatol contributor: fullname: Davis – volume: 7 start-page: CD006401 year: 2014 ident: bib33 article-title: Statins for children with familial hypercholesterolemia publication-title: Cochrane database Syst Rev contributor: fullname: Kovanen – volume: 307 start-page: 257 year: 2012 end-page: 258 ident: bib28 article-title: Universal screening and drug treatment of dyslipidemia in children and adolescents publication-title: JAMA contributor: fullname: Rivara – volume: 27 start-page: 981 issue: 10 year: 2013 ident: 10.1016/j.jacl.2015.07.001_bib3 article-title: PSA screening: good evidence shows little benefit, significant harms publication-title: Oncology (Williston Park) contributor: fullname: LeFevre – volume: 367 start-page: 469 issue: 9509 year: 2006 ident: 10.1016/j.jacl.2015.07.001_bib26 article-title: Efficacy and safety of cholesterol-lowering treatment publication-title: Lancet doi: 10.1016/S0140-6736(06)68170-1 contributor: fullname: Law – volume: 108 start-page: 7 issue: 1 year: 2015 ident: 10.1016/j.jacl.2015.07.001_bib50 article-title: Pediatric dyslipidemia: recommendations for clinical management publication-title: South Med J doi: 10.14423/SMJ.0000000000000219 contributor: fullname: Wilson – volume: 128 start-page: S213 issue: Suppl 5 year: 2011 ident: 10.1016/j.jacl.2015.07.001_bib12 article-title: Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: summary report publication-title: Pediatrics – volume: 54 start-page: 151 issue: 1 year: 2013 ident: 10.1016/j.jacl.2015.07.001_bib42 article-title: HMG-CoA reductase inhibitors (statins) and bone mineral density: a meta-analysis publication-title: Bone doi: 10.1016/j.bone.2013.01.044 contributor: fullname: Liu – volume: 118 start-page: 165 issue: 1 year: 2006 ident: 10.1016/j.jacl.2015.07.001_bib11 article-title: Sensitivity and specificity of pediatric lipid determinations for adult lipid status: findings from the Princeton Lipid Research Clinics Prevalence Program Follow-up Study publication-title: Pediatrics doi: 10.1542/peds.2005-2968 contributor: fullname: Friedman – volume: 11 start-page: 18 issue: 1 year: 2011 ident: 10.1016/j.jacl.2015.07.001_bib47 article-title: Delivery of well-child care: a look inside the door publication-title: Acad Pediatr doi: 10.1016/j.acap.2010.12.008 contributor: fullname: Norlin – volume: 288 start-page: 321 issue: 3 year: 2002 ident: 10.1016/j.jacl.2015.07.001_bib5 article-title: Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial publication-title: JAMA doi: 10.1001/jama.288.3.321 contributor: fullname: Rossouw – volume: 119 start-page: 1108 issue: 8 year: 2009 ident: 10.1016/j.jacl.2015.07.001_bib49 article-title: Concentrations of low-density lipoprotein cholesterol and total cholesterol among children and adolescents in the United States publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.108.816769 contributor: fullname: Ford – volume: 64 start-page: 285 issue: 1 year: 2012 ident: 10.1016/j.jacl.2015.07.001_bib35 article-title: Use of atorvastatin in systemic lupus erythematosus in children and adolescents publication-title: Arthritis Rheum doi: 10.1002/art.30645 contributor: fullname: Schanberg – volume: 118 start-page: e964 issue: 4 year: 2006 ident: 10.1016/j.jacl.2015.07.001_bib46 article-title: Drowning in a sea of advice: pediatricians and American Academy of Pediatrics policy statements publication-title: Pediatrics doi: 10.1542/peds.2006-0652 contributor: fullname: Belamarich – volume: 55 start-page: 1121 issue: 11 year: 2010 ident: 10.1016/j.jacl.2015.07.001_bib34 article-title: Efficacy and safety of rosuvastatin therapy for children with familial hypercholesterolemia publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2009.10.042 contributor: fullname: Avis – volume: 346 start-page: 1047 issue: 14 year: 2002 ident: 10.1016/j.jacl.2015.07.001_bib1 article-title: Neuroblastoma screening at one year of age publication-title: N Engl J Med doi: 10.1056/NEJMoa012277 contributor: fullname: Schilling – volume: 165 start-page: 205 issue: 3 year: 2011 ident: 10.1016/j.jacl.2015.07.001_bib48 article-title: The anatomy of a US Preventive Services Task Force Recommendation: lipid screening for children and adolescents publication-title: Arch Pediatr Adolesc Med doi: 10.1001/archpediatrics.2010.299 contributor: fullname: Grossman – volume: 99 start-page: E5 issue: 5 year: 1997 ident: 10.1016/j.jacl.2015.07.001_bib20 article-title: Parent and physician response to children's cholesterol values of 200 mg/dL or greater: the Child and Adolescent Trial for Cardiovascular Health Experiment publication-title: Pediatrics doi: 10.1542/peds.99.5.e5 contributor: fullname: Nader – volume: 63 start-page: 2889 issue: 25 Pt B year: 2014 ident: 10.1016/j.jacl.2015.07.001_bib6 article-title: 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2013.11.002 contributor: fullname: Stone – volume: 169 start-page: 569 year: 2015 ident: 10.1016/j.jacl.2015.07.001_bib7 article-title: Application of pediatric and adult guidelines for treatment of lipid levels among US adolescents transitioning to young adulthood publication-title: JAMA Pediatr doi: 10.1001/jamapediatrics.2015.0168 contributor: fullname: Gooding – volume: 357 start-page: 2371 issue: 23 year: 2007 ident: 10.1016/j.jacl.2015.07.001_bib16 article-title: Adolescent overweight and future adult coronary heart disease publication-title: N Engl J Med doi: 10.1056/NEJMsa073166 contributor: fullname: Bibbins-Domingo – volume: 312 start-page: 1055 issue: 10 year: 2014 ident: 10.1016/j.jacl.2015.07.001_bib36 article-title: Ten-year follow-up after initiation of statin therapy in children with familial hypercholesterolemia publication-title: JAMA doi: 10.1001/jama.2014.8892 contributor: fullname: Kusters – volume: 8 start-page: 148 issue: 2 year: 2014 ident: 10.1016/j.jacl.2015.07.001_bib51 article-title: Integrated guidance on the care of familial hypercholesterolemia from the International FH Foundation publication-title: J Clin Lipidol doi: 10.1016/j.jacl.2014.01.002 contributor: fullname: Watts – volume: 32 start-page: 1924 issue: 10 year: 2009 ident: 10.1016/j.jacl.2015.07.001_bib29 article-title: Statin therapy and risk of developing type 2 diabetes: a meta-analysis publication-title: Diabetes Care doi: 10.2337/dc09-0738 contributor: fullname: Rajpathak – volume: 39 start-page: 1867 issue: 9 year: 2012 ident: 10.1016/j.jacl.2015.07.001_bib53 article-title: Disease-modifying antirheumatic drug use in the treatment of juvenile idiopathic arthritis: a cross-sectional analysis of the CARRA Registry publication-title: J Rheumatol doi: 10.3899/jrheum.120110 contributor: fullname: Beukelman – volume: 128 start-page: e1596 issue: 6 year: 2011 ident: 10.1016/j.jacl.2015.07.001_bib9 article-title: Safely doing less: a missing component of the patient safety dialogue publication-title: Pediatrics doi: 10.1542/peds.2011-2726 contributor: fullname: Schroeder – volume: 513 start-page: 507 issue: 7519 year: 2014 ident: 10.1016/j.jacl.2015.07.001_bib41 article-title: Statin treatment rescues FGFR3 skeletal dysplasia phenotypes publication-title: Nature doi: 10.1038/nature13775 contributor: fullname: Yamashita – volume: 311 start-page: 1804 issue: 17 year: 2014 ident: 10.1016/j.jacl.2015.07.001_bib44 article-title: Cholesterol testing among children and adolescents during health visits publication-title: JAMA doi: 10.1001/jama.2014.2410 contributor: fullname: Vinci – ident: 10.1016/j.jacl.2015.07.001_bib30 – volume: 97 start-page: 52C issue: 8A year: 2006 ident: 10.1016/j.jacl.2015.07.001_bib25 article-title: Statin safety: a systematic review publication-title: Am J Cardiol doi: 10.1016/j.amjcard.2005.12.010 contributor: fullname: Law – volume: 275 start-page: 768 issue: 10 year: 1996 ident: 10.1016/j.jacl.2015.07.001_bib19 article-title: Outcomes of a field trial to improve children's dietary patterns and physical activity. The Child and Adolescent Trial for Cardiovascular Health. CATCH collaborative group publication-title: JAMA doi: 10.1001/jama.1996.03530340032026 contributor: fullname: Luepker – volume: 116 start-page: 878 issue: 6 year: 1982 ident: 10.1016/j.jacl.2015.07.001_bib23 article-title: Retest reliability of plasma cholesterol and triglyceride. The Lipid Research Clinics Prevalence Study publication-title: Am J Epidemiol doi: 10.1093/oxfordjournals.aje.a113490 contributor: fullname: Jacobs – volume: 119 start-page: 370 issue: 2 year: 2007 ident: 10.1016/j.jacl.2015.07.001_bib37 article-title: The use of statins in pediatrics: knowledge base, limitations, and future directions publication-title: Pediatrics doi: 10.1542/peds.2006-0787 contributor: fullname: Belay – volume: 73 start-page: 770 issue: 5 year: 2009 ident: 10.1016/j.jacl.2015.07.001_bib43 article-title: Epigenetic side-effects of common pharmaceuticals: a potential new field in medicine and pharmacology publication-title: Med Hypotheses doi: 10.1016/j.mehy.2008.10.039 contributor: fullname: Csoka – volume: 104 start-page: 109 issue: 2 year: 2011 ident: 10.1016/j.jacl.2015.07.001_bib27 article-title: Efficacy and safety of statin treatment for cardiovascular disease: a network meta-analysis of 170,255 patients from 76 randomized trials publication-title: QJM doi: 10.1093/qjmed/hcq165 contributor: fullname: Mills – volume: 19 start-page: 26 issue: 1 year: 1998 ident: 10.1016/j.jacl.2015.07.001_bib39 article-title: Hydrophilicity/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors publication-title: Trends Pharmacol Sci doi: 10.1016/S0165-6147(97)01147-4 contributor: fullname: Hamelin – volume: 273 start-page: 1429 issue: 18 year: 1995 ident: 10.1016/j.jacl.2015.07.001_bib22 article-title: Efficacy and safety of lowering dietary intake of fat and cholesterol in children with elevated low-density lipoprotein cholesterol. The Dietary Intervention Study in Children (DISC). The Writing Group for the DISC Collaborative Research Group publication-title: JAMA doi: 10.1001/jama.1995.03520420045036 – volume: 371 start-page: 1765 issue: 19 year: 2014 ident: 10.1016/j.jacl.2015.07.001_bib4 article-title: Korea's thyroid-cancer “epidemic”–screening and overdiagnosis publication-title: N Engl J Med doi: 10.1056/NEJMp1409841 contributor: fullname: Ahn – volume: 27 start-page: 1803 issue: 8 year: 2007 ident: 10.1016/j.jacl.2015.07.001_bib32 article-title: A systematic review and meta-analysis of statin therapy in children with familial hypercholesterolemia publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.107.145151 contributor: fullname: Avis – volume: 34 start-page: 224 issue: 1 year: 2007 ident: 10.1016/j.jacl.2015.07.001_bib52 article-title: Establishment of a pilot pediatric registry for chronic vasculitis is both essential and feasible: a Childhood Arthritis and Rheumatology Alliance (CARRA) survey publication-title: J Rheumatol contributor: fullname: Wilkinson – volume: 169 start-page: 387 issue: 3 year: 2015 ident: 10.1016/j.jacl.2015.07.001_bib31 article-title: Implications of the new American College of Cardiology/American Heart Association cholesterol guidelines for primary atherosclerotic cardiovascular disease event prevention in a multi ethnic cohort: Multi-Ethnic Study of Atherosclerosis (MESA) publication-title: Am Heart J doi: 10.1016/j.ahj.2014.12.018 contributor: fullname: Yeboah – volume: 307 start-page: 259 issue: 3 year: 2012 ident: 10.1016/j.jacl.2015.07.001_bib15 article-title: Is universal pediatric lipid screening justified? publication-title: JAMA doi: 10.1001/jama.2011.2012 contributor: fullname: Gillman – volume: 163 start-page: 812 issue: 9 year: 2009 ident: 10.1016/j.jacl.2015.07.001_bib18 article-title: Short-term change in body mass index in overweight adolescents following cholesterol screening publication-title: Arch Pediatr Adolesc Med doi: 10.1001/archpediatrics.2009.152 contributor: fullname: Doshi – volume: 35 start-page: 665 issue: 11 year: 2012 ident: 10.1016/j.jacl.2015.07.001_bib14 article-title: Cholesterol screening and management in children and young adults should start early–NO! publication-title: Clin Cardiol doi: 10.1002/clc.22075 contributor: fullname: Schroeder – volume: 170 start-page: 584 issue: 7 year: 2010 ident: 10.1016/j.jacl.2015.07.001_bib8 article-title: Less is more publication-title: Arch Intern Med doi: 10.1001/archinternmed.2010.48 contributor: fullname: Redberg – volume: 89 start-page: 1159 issue: 6 Pt 2 year: 1992 ident: 10.1016/j.jacl.2015.07.001_bib21 article-title: Parents' behavior and attitudes toward screening children for high serum cholesterol levels publication-title: Pediatrics doi: 10.1542/peds.89.6.1159 contributor: fullname: Lannon – volume: 42 start-page: 732 issue: 5 year: 1996 ident: 10.1016/j.jacl.2015.07.001_bib24 article-title: Variability in cholesterol measurements: comparison of calculated and direct LDL cholesterol determinations publication-title: Clin Chem doi: 10.1093/clinchem/42.5.732 contributor: fullname: Schectman – volume: 98 start-page: 383 issue: 3 Pt 1 year: 1996 ident: 10.1016/j.jacl.2015.07.001_bib13 article-title: Failure of current guidelines for cholesterol screening in urban African-American adolescents publication-title: Pediatrics doi: 10.1542/peds.98.3.383 contributor: fullname: Rifai – volume: 7 start-page: CD006401 year: 2014 ident: 10.1016/j.jacl.2015.07.001_bib33 article-title: Statins for children with familial hypercholesterolemia publication-title: Cochrane database Syst Rev contributor: fullname: Vuorio – volume: 143 start-page: 87 issue: 1 year: 2014 ident: 10.1016/j.jacl.2015.07.001_bib40 article-title: Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease publication-title: Pharmacol Ther doi: 10.1016/j.pharmthera.2014.02.007 contributor: fullname: Yeganeh – volume: 164 start-page: 572 issue: 3 year: 2014 ident: 10.1016/j.jacl.2015.07.001_bib45 article-title: Implementation of lipid screening guidelines in children by primary pediatric providers publication-title: J Pediatr doi: 10.1016/j.jpeds.2013.10.027 contributor: fullname: Dixon – volume: 120 start-page: e215 issue: 1 year: 2007 ident: 10.1016/j.jacl.2015.07.001_bib10 article-title: Screening for lipid disorders in children: US Preventive Services Task Force recommendation statement publication-title: Pediatrics doi: 10.1542/peds.2006-1812 – volume: 16 start-page: 1265 issue: 4 year: 1998 ident: 10.1016/j.jacl.2015.07.001_bib2 article-title: Spontaneous regression of localized neuroblastoma detected by mass screening publication-title: J Clin Oncol doi: 10.1200/JCO.1998.16.4.1265 contributor: fullname: Yamamoto – volume: 130 start-page: 349 issue: 2 year: 2012 ident: 10.1016/j.jacl.2015.07.001_bib38 article-title: Overly aggressive new guidelines for lipid screening in children: evidence of a broken process publication-title: Pediatrics doi: 10.1542/peds.2012-0481 contributor: fullname: Newman – volume: 31 start-page: 105 issue: 2 year: 2015 ident: 10.1016/j.jacl.2015.07.001_bib17 article-title: Obesity-it must not remain the neglected risk factor in cardiology publication-title: Can J Cardiol doi: 10.1016/j.cjca.2014.12.017 contributor: fullname: Poirier – volume: 307 start-page: 257 issue: 3 year: 2012 ident: 10.1016/j.jacl.2015.07.001_bib28 article-title: Universal screening and drug treatment of dyslipidemia in children and adolescents publication-title: JAMA doi: 10.1001/jama.2011.1916 contributor: fullname: Psaty |
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| Snippet | Abstract Few pediatric guidelines have generated the amount or intensity of controversy that the pediatric lipid guidelines have. In the following article, I... Few pediatric guidelines have generated the amount or intensity of controversy that the pediatric lipid guidelines have. In the following article, I will... |
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| SubjectTerms | Cardiovascular Cardiovascular Diseases - diagnosis Cardiovascular Diseases - therapy Cardiovascular risk Child Children Controversy Guidelines Health Plan Implementation Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Lipid screening Mass Screening Overdiagnosis Pediatrics Practice Guidelines as Topic Statin |
| Title | Counterpoint: The evidence does not support universal screening and treatment in children |
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