Sulforaphane preconditioning of the Nrf2/HO-1 defense pathway protects the cerebral vasculature against blood–brain barrier disruption and neurological deficits in stroke

Disruption of the blood–brain barrier (BBB) and cerebral edema are the major pathogenic mechanisms leading to neurological dysfunction and death after ischemic stroke. The brain protects itself against infarction via activation of endogenous antioxidant defense mechanisms, and we here report the fir...

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Bibliographic Details
Published in:	Free radical biology & medicine Vol. 65; pp. 1012 - 1022
Main Authors:	Alfieri, Alessio, Srivastava, Salil, Siow, Richard C.M, Cash, Diana, Modo, Michel, Duchen, Michael R, Fraser, Paul A, Williams, Steven C.R, Mann, Giovanni E
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-12-2013
Subjects:	Animals antioxidants astrocytes blood-brain barrier Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Blood-Brain Barrier - pathology brain Cerebral Arteries - drug effects Cerebral Arteries - enzymology death defense mechanisms edema endothelium Gene Expression heme oxygenase (biliverdin-producing) Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism infarction Infarction, Middle Cerebral Artery - drug therapy Infarction, Middle Cerebral Artery - metabolism Isothiocyanates - pharmacology Isothiocyanates - therapeutic use magnetic resonance imaging Male Membrane Proteins - genetics Membrane Proteins - metabolism Microvessels - enzymology Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism nutritional intervention Oxidative Stress protein synthesis Psychomotor Disorders - metabolism Psychomotor Disorders - prevention & control rats Rats, Sprague-Dawley Reperfusion Injury - metabolism Reperfusion Injury - prevention & control Signal Transduction stroke Up-Regulation MCAo BBB HO Heme oxygenase 3,3′-diaminobenzidine peroxiredoxin 1 Iba1 Gliovascular complex Blood–brain barrier Nrf2 RNS Sulforaphane rat endothelial cell antigen-1 ionized calcium binding adaptor molecule 1 reactive oxygen species reactive nitrogen species antioxidant response element Stroke DAB DAPI RECA-1 Kelch-like ECH associated protein 1 GFAP ARE 4,6-diamidino-2-phenylindole ROS Keap1 Preconditioning Prx1 glial fibrillary acidic protein nuclear factor erythroid 2-related factor 2 middle cerebral artery occlusion
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