Spatially modulated ablation driven by chaotic attractors in human lung epithelial cancer cells

• Published in: Biomedical physics & engineering express Vol. 10; no. 3
• Main Authors: Martines-Arano, Hilario, Valdivia-Flores, Alejandra, Castillo-Cruz, Juan, García-Pérez, Blanca Estela, Torres-Torres, Carlos
• Format: Journal Article
• Language: English
• Published: England 01-05-2024
• Subjects: A549 Cells; Cell Line, Tumor; Epithelial Cells - metabolism; Epithelial Cells - radiation effects; Humans; Laser Therapy - methods; Lasers; Lung Neoplasms - pathology; Lung Neoplasms - radiotherapy; Nonlinear Dynamics; fractional calculus; photodamage; nanosecond laser ablation; chaotic arneodo system; ring-shaped ablation; lung epithelial cancer cells
• ISSN: 2057-1976
• DOI: 10.1088/2057-1976/ad39f1

A significant modification in photoinduced energy transfer in cancer cells is reported by the assistance of a dynamic modulation of the beam size of laser irradiation. Human lung epithelial cancer cells in monolayer form were studied. In contrast to the quantum and thermal ablation effect promoted by a standard focused Gaussian beam, a spatially modulated beam can caused around 15% of decrease in the ablation threshold and formation of a ring-shaped distribution of the photothermal transfer effect. Optical irradiation was conducted in A549 cells by a 532 nm single-beam emerging from a Nd:YVO4 system. Ablation effects derived from spatially modulated convergent waves were controlled by an electrically focus-tunable lens. The proposed chaotic behavior of the spatial modulation followed an Arneodo chaotic oscillator. Fractional dynamic thermal transport was analyzed in order to describe photoenergy in propagation through the samples. Immediate applications of chaos theory for developing phototechnology devices driving biological functions or phototherapy treatments can be considered.