Suppressor T cells in human diseases

Although central and peripheral tolerance are important for the regulation of human immune responses to self- and microbial antigens, an important role of suppressor CD4(+) CD25(+) T cells is suggested from the recent investigations of human autoimmune diseases and HIV. These new data provide increa...

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Bibliographic Details
Published in:	The Journal of experimental medicine Vol. 200; no. 3; pp. 273 - 276
Main Authors:	Baecher-Allan, Clare, Hafler, David A
Format:	Journal Article
Language:	English
Published:	United States The Rockefeller University Press 02-08-2004
Subjects:	Arthritis, Rheumatoid - immunology CD4 Antigens - analysis HIV Infections - immunology Human immunodeficiency virus Humans Multiple Sclerosis - immunology Receptors, Interleukin-2 - analysis T-Lymphocytes, Regulatory - immunology
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Summary:	Although central and peripheral tolerance are important for the regulation of human immune responses to self- and microbial antigens, an important role of suppressor CD4(+) CD25(+) T cells is suggested from the recent investigations of human autoimmune diseases and HIV. These new data provide increasing evidence that altered function of CD4(+) CD25(+) T cells may be an important factor in a wide range of human inflammatory and infectious diseases.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Feature-3 ObjectType-Commentary-1 Address correspondence to Clare Baecher-Allan, 77 Ave. Louis Pasteur, Harvard Medical School, Boston, MA 02115. Tel: (617) 525-5330; Fax: (617) 525-5333; email: callan@rics.bwh.harvard.edu
ISSN:	0022-1007 1540-9538 1892-1007
DOI:	10.1084/jem.20040812