Increase of papillary thyroid microcarcinoma and a plea for restrictive treatment: A retrospective study of 1,391 prospective documented patients

• Published in: Surgery Vol. 159; no. 2; pp. 503 - 511
• Main Authors: Gschwandtner, Elisabeth, MD, Klatte, Tobias, MD, Swietek, Natalia, MD, Bures, Claudia, MD, Kober, Friedrich, MD, Ott, Johannes, MD, Schultheis, Andrea, MD, Neuhold, Nikolaus, MD, Hermann, Michael, MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-02-2016
• Subjects: Adult; Aged; Austria - epidemiology; Carcinoma, Papillary - epidemiology; Carcinoma, Papillary - mortality; Carcinoma, Papillary - surgery; Databases, Factual; Female; Follow-Up Studies; Humans; Lymph Node Excision; Male; Middle Aged; Neoplasm Recurrence, Local; Reoperation; Retrospective Studies; Surgery; Survival Analysis; Thyroid Neoplasms - epidemiology; Thyroid Neoplasms - mortality; Thyroid Neoplasms - surgery; Thyroidectomy; Treatment Outcome; Austria
• ISSN: 0039-6060; 1532-7361
• DOI: 10.1016/j.surg.2015.06.015

Background The incidence of papillary thyroid microcarcinomas (PMCs) has increased sharply and therefore the lack of consensus for treatment has become a clinical dilemma. Our aim was to evaluate a less-radical approach. Methods This study includes 1,391 patients with PMC treated at a single surgical referral center in the endemic goiter area in Austria. Data, including long-term follow-up examinations with a median follow-up time of 7 years, were collected from the institutional surgery database. Results Of the 1,391 patients, 947 (68.1%) had a near-total or total thyroidectomy; 1,090 patients (78.3%) had no lymphadenectomy, and 1,136 patients (81.7%) did not receive radioiodine treatment. Twenty-one patients (1.5%) underwent reoperation, 5 because of lymph node recurrence (0.4%), 16 with clinically benign recurrence, including 4 cases of another PMC. There were no recurrences in the thyroid bed and no disease-related deaths. Risk factors for lymph node recurrences were nonincidental finding, nodal metastases at presentation, young age, aggregate tumor size, and subcapsular tumor localization. Multifocality, sex, maximum tumor size, and the extent of surgery were not relevant factors. Conclusion Nodal recurrence is rare and reoperation cured all patients. Micrometastases are not of clinical relevance. The postoperative findings of most PMCs suggest that, even if multifocal, a limited approach without completion thyroidectomy, lymphadenectomy and radioiodine treatment is sufficient. In case of pre- or intraoperative clinically suspected nodal metastases or postoperatively diagnosed risk factors we propose the standard radical procedure. Routine preoperative cervical lymph node sonography is advisable before any thyroid surgery.