Neuronal Nitric-oxide Synthase Interaction with Calmodulin-Troponin C Chimeras

Calmodulin (CaM) binding activates neuronal nitric-oxide synthase (nNOS) catalytic functions and also up-regulates electron transfer into its flavin and heme centers. Here, we utilized seven tight binding CaM-troponin C chimeras, which variably activate nNOS NO synthesis to examine the relationship...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 273; no. 10; pp. 5451 - 5454
Main Authors:	Gachhui, Ratan, Abu-Soud, Husam M., Ghoshà, Dipak K., Presta, Anthony, Blazing, Michael A., Mayer, Bernd, George, Samuel E., Stuehr, Dennis J.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 06-03-1998 American Society for Biochemistry and Molecular Biology
Subjects:	Amino Acid Sequence Animals Brain - physiology Calmodulin - chemistry Calmodulin - pharmacology Cytochrome c Group - metabolism Electron Transport - physiology Enzyme Activation - physiology Flavoproteins - metabolism Heme - metabolism Kinetics Molecular Sequence Data NADP - metabolism Neurons - enzymology Nitric Oxide - metabolism Nitric Oxide Synthase - metabolism Rats Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - pharmacology Sequence Alignment Troponin C - chemistry Troponin C - pharmacology
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