Severe CD4 T Cell-Mediated Immunopathology in Murine Schistosomiasis Is Dependent on IL-12p40 and Correlates with High Levels of IL-17

C57BL/6 mice infected with the helminth Schistosoma mansoni develop small hepatic granulomas around parasite eggs, but concomitant immunization with soluble schistosome egg Ags (SEA) in CFA (SEA/CFA) causes marked exacerbation of the lesions in a Th1-dominated environment characterized by high level...

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Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 175; no. 6; pp. 3920 - 3926
Main Authors:	Rutitzky, Laura I, Lopes da Rosa, Jessica R, Stadecker, Miguel J
Format:	Journal Article
Language:	English
Published:	United States Am Assoc Immnol 15-09-2005
Subjects:	Animals Antigens, Helminth - administration & dosage Antigens, Helminth - pharmacology CD4-Positive T-Lymphocytes - immunology Female Immunization Inflammation - etiology Inflammation - prevention & control Interferon-gamma - analysis Interleukin-12 - deficiency Interleukin-12 - immunology Interleukin-12 Subunit p35 Interleukin-12 Subunit p40 Interleukin-17 - analysis Interleukin-17 - immunology Interleukin-23 Interleukin-23 Subunit p19 Interleukins - analysis Mice Mice, Inbred C57BL Mice, Knockout Protein Subunits - deficiency Protein Subunits - immunology Schistosoma mansoni Schistosomiasis - immunology Schistosomiasis - pathology
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