Facile solid phase peptide synthesis with a Re-lysine conjugate generated via a one-pot procedure

We have synthesized a Re(CO)3-modified lysine via a one-pot Schiff base formation reaction that can be used in the solid phase peptide synthesis. To demonstrate its potential use, we have attached it to a neurotensin fragment and observed uptake into human umbilical vascular endothelial cells.

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Bibliographic Details
Published in:	Dalton transactions : an international journal of inorganic chemistry Vol. 43; no. 30; p. 11452
Main Authors:	Chanawanno, Kullapa, Caporoso, Joel, Kondeti, Vinay, Paruchuri, Sailaja, Leeper, Thomas C, Herrick, Richard S, Ziegler, Christopher J
Format:	Journal Article
Language:	English
Published:	England 14-08-2014
Subjects:	Amino Acid Sequence Endothelial Cells - metabolism Humans Lysine - chemistry Neurotensin - chemistry Neurotensin - metabolism Solid-Phase Synthesis Techniques - methods
Online Access:	Get more information
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Description
Summary:	We have synthesized a Re(CO)3-modified lysine via a one-pot Schiff base formation reaction that can be used in the solid phase peptide synthesis. To demonstrate its potential use, we have attached it to a neurotensin fragment and observed uptake into human umbilical vascular endothelial cells.
ISSN:	1477-9234
DOI:	10.1039/c4dt01129e