The Cytotoxicity of Duocarmycin Analogues is Mediated through Alkylation of DNA, not Aldehyde Dehydrogenase 1: A Comment

The answer lies in the DNA: Recent claims that the alkylation of a particular protein contributes to the cytotoxicity of the duocarmycins could not be substantiated. The evidence, like the fluorescent signal derived from a clickable analogue, points instead to a reaction occurring in the nucleus.

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Bibliographic Details
Published in:	Angewandte Chemie International Edition Vol. 52; no. 21; pp. 5442 - 5446
Main Authors:	Tercel, Moana, McManaway, Sarah P., Leung, Euphemia, Liyanage, H. D. Sarath, Lu, Guo-Liang, Pruijn, Frederik B.
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 17-05-2013 WILEY‐VCH Verlag Wiley Subscription Services, Inc
Edition:	International ed. in English
Subjects:	activity-based protein profiling antitumor agents biological activity DNA damage duocarmycin Humans Isoenzymes - antagonists & inhibitors Retinal Dehydrogenase - antagonists & inhibitors
Online Access:	Get full text
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Summary:	The answer lies in the DNA: Recent claims that the alkylation of a particular protein contributes to the cytotoxicity of the duocarmycins could not be substantiated. The evidence, like the fluorescent signal derived from a clickable analogue, points instead to a reaction occurring in the nucleus.
Bibliography:	ark:/67375/WNG-5D52R6QH-F istex:C258C09838BF57FAEE7527042DBB61A09521F5B1 This research was funded by the Foundation for Research, Science and Technology, NZ, and the Auckland Division of the Cancer Society of New Zealand. The authors thank Dr. Nicholas Lloyd for technical assistance. Auckland Division of the Cancer Society of New Zealand Foundation for Research, Science and Technology, NZ ArticleID:ANIE201208373 SourceType-Other Sources-1 content type line 63 ObjectType-Correspondence-1 ObjectType-Commentary-2 ObjectType-Article-3
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201208373