Obstetric and Perinatal Outcomes in Pregnant Women with Lupus: Retrospective Study in a Portuguese Tertiary Center

• Published in: Revista Brasileira de ginecologia e obstetrícia Vol. 45; no. 10; pp. e568 - e574
• Main Authors: Jorge, Inês Ferreira, Frade, Joana Mourão Vieitez, Capela, Susana Paula Leonardo Dias Abreu, Graça, André Laboreiro Ferreira Mendes da, Grilo, Maria Luísa Aleixo Gomes Pinto, Centeno, Ana Mónica Miguel Mendonça de Castro
• Format: Journal Article
• Language: English
• Published: Federação Brasileira das Sociedades de Ginecologia e Obstetrícia 01-10-2023
• Subjects: lupus erythematosus; neonatal systemic lupus erythematosus; OBSTETRICS & GYNECOLOGY; pregnancy; pregnancy outcome; lupus erythematosus; gravidez; resultado da gravidez; pregnancy; pregnancy outcome; neonatal systemic lupus erythematosus; lúpus eritematoso; lúpus eritematoso sistêmico neonatal
• ISSN: 0100-7203; 1806-9339; 1806-9339
• DOI: 10.1055/s-0043-1772481

Objective Pregnancy in women with lupus poses a higher risk of complications compared with the general population. The present study aimed to determine and describe the obstetric and neonatal outcomes of pregnant women with lupus.
Materials and Methods We conducted an observational retrospective study of pregnant women with the diagnosis of lupus, who were selected and followed at the Maternal-Fetal Medicine Clinic of our institution between January 2013 and July 2018. We analyzed 59 pregnancies and 52 newborns, and collected data regarding sociodemographic features, the preconception period, pregnancy, childbirth, postpartum and the newborn. A descriptive analysis of the variables was performed.
Results In 58% of the cases, the pregnancy was uneventful. We registered flares in 25% of the cases, preeclampsia in 3%, fetal growth restriction in 12%, gestational loss in 10%, preterm labor in 10%, postpartum complications in 20%, and small for gestational age newborns in 17% of the cases.
Conclusions Most pregnancies in women with lupus have favorable obstetric and neonatal outcomes. Prenatal counseling, adequate multidisciplinary surveillance, and optimized treatment of the disease are fundamental pillars for these good results.