Cytotoxicity and anti-inflammatory activities of Gallesia integrifolia (Phytolaccaceae) fruit essential oil

• Published in: Natural product research Vol. 36; no. 11; pp. 2878 - 2883
• Main Authors: Bortolucci, Wanessa de Campos, Raimundo, Keila Fernanda, Fernandez, Carla Maria Mariano, Calhelha, Ricardo C, Ferreira, Isabel C F R, Barros, Lillian, Gonçalves, José Eduardo, Linde, Giani Andrea, Colauto, Nelson Barros, Gazim, Zilda Cristiani
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis Ltd 01-06-2022
• Subjects: Adenocarcinoma; Animals; Anti-inflammatory agents; Anti-Inflammatory Agents - chemistry; Breast; Carcinoma; Cervical carcinoma; Cervix; Chemical composition; Cytotoxicity; Dimethyl trisulfide; Essential oils; Fruit - chemistry; Fruits; Gallesia integrifolia; Gas chromatography; Hepatocellular carcinoma; Hepatocytes; Inflammation; Lung carcinoma; Mass spectrometry; Mass spectroscopy; Nitric oxide; Oils, Volatile - chemistry; Phytolaccaceae - chemistry; Swine; Toxicity; Tumor cell lines; Tumor cells; Tumors; Essential oil; antitumoral; inflammation; Pau d’alho; organosulfurates
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2021.1925270

The chemical composition of
fruits essential oil was obtained by hydrodistillation using a modified Clevenger apparatus was investigated by gas chromatography coupled to mass spectrometry (GC/MS). In addition, the cytotoxicity activity against human tumor cell lines MCF-7 (breast adenocarcinoma), NCI-H460 (large cell lung carcinoma), HeLa (cervical carcinoma), and HepG2 (hepatocellular carcinoma), and non-tumor PLP2 (porcine liver primary cells) as well as the anti-inflammatory action was proposal. The compounds were predominantly organosulfates (2,8-dithianonane, dimethyl trisulfide, and lenthionine). Anti-inflammatory activity that provides 50% inhibition of nitric oxide production (55 µg/mL) of essential oil of the fruits. It also presents cytotoxic activity against MCF-7 (GI
= 66 µg/mL), NCI-H-460 (GI
= 147 µg/mL), HeLa (GI
= 182 µg/mL) and HepG2 (GI
= 240 µg/mL). The essential oil is more active in tumor cells than in non-tumor cells and the GI
values for essential oil reported in our work support future studies.