Next steps in Ewing sarcoma (epi-)genomics

Next steps in Ewing sarcoma (epi-)genomics

[...]more copy number variations were found in EwS with STAG2-mutation (6). Besides GGAA-mSats, also germline variation in the exome may contribute to the clinical phenotypes in EwS. [...]EWSR1-FLI1 likely hijacks the open chromatin structure of MSCs, to eventually induce total nucleosome loss and u...

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Bibliographic Details
Published in:Future oncology (London, England) Vol. 13; no. 14; pp. 1207 - 1211
Main Authors: Sannino, Giuseppina, Orth, Martin F, Grünewald, Thomas GP
Format: Journal Article
Language:English
Published: England Future Medicine Ltd 01-06-2017
Subjects:
Cancer
Cell cycle
Cell division
Deoxyribonucleic acid
DNA
DNA methylation
Epigenetics
Ewing sarcoma
Ewings sarcoma
Genes
Genomes
Genomics
Mutation
Patients
RNA polymerase
STAG2
Studies
Transcription factors
Tumorigenesis
Tumors
United States > US
EWSR1–FLI1
genomics
Ewing sarcoma
STAG2
epigenetics
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Summary:[...]more copy number variations were found in EwS with STAG2-mutation (6). Besides GGAA-mSats, also germline variation in the exome may contribute to the clinical phenotypes in EwS. [...]EWSR1-FLI1 likely hijacks the open chromatin structure of MSCs, to eventually induce total nucleosome loss and unfold its oncogenic potential. Interestingly, a more stem cell-like methylation signature correlated positively with STAG2-mutation, whereas a more EwS-specific signature correlated with TP53-mutation (27). Since DNA methylation is highly heterogeneous within each tumor and as higher epigenetic intratumor heterogeneity appeared to correlate with metastasis (27), this might be partially attributable to subclonal STAG2-mutations.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Editorial-2
ObjectType-Commentary-1
ISSN:1479-6694
1744-8301
DOI:10.2217/fon-2017-0159