Hyaluronic acid (hyaluronan): a review

Hyaluronic acid (hyaluronan): a review

Hyaluronic acid (HA) is a high molecular weight biopolysacharide, discovered in 1934, by Karl Meyer and his assistant, John Palmer in the vitreous of bovine eyes. Hyaluronic acid is a naturally occurring biopolymer, which has important biological functions in bacteria and higher animals including hu...

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Bibliographic Details
Published in:Veterinární medicína Vol. 53; no. 8; pp. 397 - 411
Main Authors: Necas, J., Bartosikova, L., Brauner, P., Kolar, J.
Format: Journal Article
Language:English
Published: Prague Czech Academy of Agricultural Sciences (CAAS) 01-08-2008
Czech Academy of Agricultural Sciences
Subjects:
Biopolymers
Connective tissues
Hyaluronic acid
Membrane proteins
metabolism
Molecular weight
Synovial fluid
toxicity
Umbilical cord
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Summary:Hyaluronic acid (HA) is a high molecular weight biopolysacharide, discovered in 1934, by Karl Meyer and his assistant, John Palmer in the vitreous of bovine eyes. Hyaluronic acid is a naturally occurring biopolymer, which has important biological functions in bacteria and higher animals including humans. It is found in most connective tissues and is particularly concentrated in synovial fluid, the vitreous fluid of the eye, umbilical cords and chicken combs. It is naturally synthesized by a class of integral membrane proteins called hyaluronan synthases, and degraded by a family of enzymes called hyaluronidases. This review describes metabolisms, different physiological and pathological functions, basic pharmacological properties, and the clinical use of hyaluronic acid.
ISSN:0375-8427
1805-9392
DOI:10.17221/1930-VETMED