Induction of apoptosis by apicularen A in human promyelocytic leukemia cell line HL-60

Apicularen A, a macrolide isolated from the myxobacterial genus Chondromyces, suppressed the proliferation of human promyelocytic leukemia cells (HL-60 cells), increased the release of lactate dehydrogenase and induced condensation and fragmentation of chromatin at 1 to 100 nM. In addition, it induc...

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Bibliographic Details
Published in:	Planta medica Vol. 71; no. 4; p. 306
Main Authors:	Hong, Jangja, Ishihara, Kenji, Zee, Okpyo, Ohuchi, Kazuo
Format:	Journal Article
Language:	English
Published:	Germany 01-04-2005
Subjects:	Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - therapeutic use Apoptosis - drug effects Bridged Bicyclo Compounds, Heterocyclic - administration & dosage Bridged Bicyclo Compounds, Heterocyclic - pharmacology Bridged Bicyclo Compounds, Heterocyclic - therapeutic use DNA Fragmentation - drug effects Flow Cytometry HL-60 Cells - drug effects Humans Leukemia, Myeloid - drug therapy Macrolides - administration & dosage Macrolides - pharmacology Macrolides - therapeutic use Phytotherapy
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