Sister-chromatid exchange in cultured lymphocytes of ewes and their newborn lambs

Sister-chromatid exchange in cultured lymphocytes of ewes and their newborn lambs

The incidence of sister-chromatid exchange (SCE) in cultured lymphocytes of ewes and their newborn lambs was determined using the BrdU-Giemsa technique. In all ewe-lamb pairs, the SCE rate in the lambs was less than that of the ewes. The mean SCE frequencies per chromosome of the ewes after lambing...

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Bibliographic Details
Published in:Mutation research Vol. 140; no. 2-3; p. 117
Main Authors: Dunkelberg, H, Krames, J
Format: Journal Article
Language:English
Published: Netherlands 01-01-1984
Subjects:
Adolescent
Adult
Aged
Aging
Animals
Animals, Newborn
Cell Division
Cells, Cultured
Child
Child, Preschool
Crossing Over, Genetic
Female
Humans
Infant
Infant, Newborn
Lymphocytes - physiology
Middle Aged
Pregnancy
Sheep
Sister Chromatid Exchange
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Summary:The incidence of sister-chromatid exchange (SCE) in cultured lymphocytes of ewes and their newborn lambs was determined using the BrdU-Giemsa technique. In all ewe-lamb pairs, the SCE rate in the lambs was less than that of the ewes. The mean SCE frequencies per chromosome of the ewes after lambing and of the newborn lambs were 0.1909 and 0.1581, respectively. The statistical analysis shows that a significant difference exists between SCE in the adult female sheep and their lambs. At the same time, a negative correlation was observed between SCE rate and cell proliferation. The results of this study are compared with those of previous reports on age-dependency of SCE.
ISSN:0027-5107
DOI:10.1016/0165-7992(84)90054-X