Epigenetics of cancer-associated muscle catabolism

Cancer patients are commonly affected by cachexia, a wasting process involving muscle and fat. Specifically, loss of the muscle compartment has been associated with poor prognosis and suboptimal response to therapy. Nutritional support has been ineffective in treating this process leading to investi...

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Bibliographic Details
Published in:	Epigenomics Vol. 9; no. 10; pp. 1259 - 1265
Main Authors:	Carr, Ryan M, Enriquez-Hesles, Elisa, Olson, Rachel LO, Jatoi, Aminah, Doles, Jason, Fernandez-Zapico, Martin E
Format:	Journal Article
Language:	English
Published:	England Future Medicine Ltd 01-10-2017
Subjects:	Apoptosis Atrophy Cachexia Cancer Catabolism Cytokines Deoxyribonucleic acid DNA DNA methylation Enzymes Epigenetics Kinases Medical prognosis Molecular modelling muscle wasting Muscles Muscular dystrophy Musculoskeletal system Myogenesis Phenotypes Protein synthesis Proteins Therapeutic applications Transcription factors weight loss weight loss cancer epigenetics muscle wasting cachexia
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Summary:	Cancer patients are commonly affected by cachexia, a wasting process involving muscle and fat. Specifically, loss of the muscle compartment has been associated with poor prognosis and suboptimal response to therapy. Nutritional support has been ineffective in treating this process leading to investigations into the underlying molecular processes governing muscle catabolism. In this commentary, we discuss the molecular mechanisms of cancer-associated muscle metabolism and the epigenetic processes responsible for the muscle wasting phenotype. Ultimately, we highlight how the epigenome may serve as a promising therapeutic target in reversing cancer-associated muscle catabolism.
Bibliography:	SourceType-Other Sources-1 content type line 63 ObjectType-Editorial-2 ObjectType-Commentary-1
ISSN:	1750-1911 1750-192X
DOI:	10.2217/epi-2017-0058