Foldamers containing γ-amino acid residues or their analogues: structural features and applications

• Published in: Amino acids Vol. 41; no. 3; pp. 687 - 707
• Main Authors: Bouillère, Francelin, Thétiot-Laurent, Sophie, Kouklovsky, Cyrille, Alezra, Valérie
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01-08-2011; Springer Verlag
• Subjects: Amino acids; Amino Acids - chemistry; Analogue; Analytical Chemistry; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Biochemical Engineering; Biochemistry; Biological; Biomedical and Life Sciences; Chemical Sciences; Life Sciences; Neurobiology; Oligomers; Organic chemistry; Peptides; Peptides - chemistry; Peptides - metabolism; Peptides - pharmacology; Peptidomimetics; Protein Conformation; Proteomics; Residues; Review Article; Gamma-amino acid; Hybrid peptide; Gamma-peptide; Foldamer; Secondary structure
• ISSN: 0939-4451; 1438-2199
• DOI: 10.1007/s00726-011-0893-3

Over the past 20 years, the field of foldamers has rapidly increased. Many β-peptides have already been described and shown interesting properties. γ-Peptides have more recently emerged but seem to be very interesting as well. In this review, we will cover every peptidomimetic oligomer that contains a γ-amino acid or an analogue and presents a structural feature. It includes γ-peptides but also hybrid α–γ peptides, β–γ peptides and analogues such as oligoureas or aminoxy acids. We will present the biological properties of these oligomers.