Early predictors of corticosteroid response in acute severe autoimmune hepatitis: a nationwide multicenter study

• Published in: Alimentary pharmacology & therapeutics Vol. 56; no. 1; pp. 131 - 143
• Main Authors: Téllez, Luis, Sánchez Rodríguez, Eugenia, Rodríguez de Santiago, Enrique, Llovet, Laura, Gómez‐Outomuro, Ana, Díaz‐Fontenla, Fernando, Álvarez López, Patricia, García‐Eliz, María, Amaral, Carla, Sánchez‐Torrijos, Yolanda, Fortea, José Ignacio, Ferre‐Aracil, Carlos, Rodríguez‐Perálvarez, Manuel, Abadía, Marta, Gómez‐Camarero, Judith, Olveira, Antonio, Calleja, José Luis, Crespo, Javier, Romero, Manuel, Hernández‐Guerra, Manuel, Berenguer, Marina, Riveiro‐Barciela, Mar, Salcedo, Magdalena, Rodríguez, Manuel, Londoño, María Carlota, Albillos, Agustín, Omella, Ignacio, Trapero, María, Gea, Francisco, Alvarez‐Navascués, Carmen, González‐Diéguez, María‐Luisa, Romero‐Gómez, Manuel
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01-07-2022; John Wiley and Sons Inc
• Subjects: Acute Disease; Adolescent; Adrenal Cortex Hormones - therapeutic use; Ascites; Brain Diseases; Corticosteroids; Corticosteroids in Autoimmune Hepatitis; Encephalopathy; Hepatitis; Hepatitis, Autoimmune - diagnosis; Hepatitis, Autoimmune - drug therapy; Humans; Liver transplantation; Medical prognosis; Original; Patients; Prognosis; Retrospective Studies; Severity of Illness Index; Steroids; Transplants & implants
• ISSN: 0269-2813; 1365-2036
• DOI: 10.1111/apt.16926

Summary
Background and Aims
To assess whether corticosteroids improve prognosis in patients with AS‐AIH, and to identify factors at therapy initiation and during therapy predictive of the response to corticosteroids.
Methods
This was a retrospective cohort study including all patients with AS‐AIH admitted to 13 tertiary centres from January 2002 to January 2019. The composite primary outcome was death or liver transplantation within 90 days of admission. Kaplan–Meier and Cox regression methods were used for data analysis.
Results
Of 242 consecutive patients enrolled (mean age [SD] 49.7 [16.8] years), 203 received corticosteroids. Overall 90‐day transplant‐free survival was 61.6% (95% confidence interval [CI] 55.4–67.7). Corticosteroids reduced the risk of a poor outcome (adjusted hazard ratio [HR] 0.25; 95% CI 0.2–0.4), but this treatment failed in 30.5%. An internally validated nomogram composed of older age, MELD, encephalopathy and ascites at the initiation of corticosteroids accurately predicted the response (C‐index 0.82; [95% CI 0.8–0.9]). In responders, MELD significantly improved from days 3 to 14 but remained unchanged in non‐responders. MELD on day 7 with a cut‐off of 25 (sensitivity 62.5%[95% CI: 47.0–75.8]; specificity 95.2% [95% CI: 89.9–97.8]) was the best univariate predictor of the response. Prolonging corticosteroids did not increase the overall infection risk (adjusted HR 0.75; 95% CI 0.3–2.1).
Conclusion
Older patients with high MELD, encephalopathy or ascites at steroid therapy initiation and during treatment are unlikely to show a favourable response and so prolonged therapy in these patients, especially if they are transplantation candidates, should be avoided.
Corticosteroids in acute‐severe autoimmune hepatits.